Amino acid-induced rapid gelation and mechanical reinforcement of hydrogels with low-hysteresis and self-recoverable and fatigue-resistant properties

Abstract

Hydrogels with rapid gelation ability and robust mechanical properties are highly desirable for nascent applications in biomedical, wearable electronic, industrial and agricultural fields. However, current rapid-gelation hydrogels are compromised by...

Designing Pathway-Controlled Multicomponent Ultrashort Peptide Hydrogels with Diverse Functionalities at the Nanoscale for Directing Cellular Behavior

“…Upon correlating the measured mechanical strength with the microscopic as well as spectroscopic results of the coassembled hydrogels, it can be stated that the thinner and higher-ordered arrangement of fibers obtained from the heat–cool method induced fabrication of stiffer gels, whereas the flat and twisted arrangement of fibers obtained from the sonication method triggered the formation of weaker gels (Figure S5). It has also been reported that the presence of serine can provide additional hydrogen-bonding interactions which could further help in strengthening the mechanical properties of the coassembled system . In order to prove this, we have also evaluated the mechanical strength of only Cbz-FF-OH hydrogels formed through both heat–cool and sonication methods.…”

“…It has also been reported that the presence of serine can provide additional hydrogen-bonding interactions which could further help in strengthening the mechanical properties of the coassembled system. 79 In order to prove this, we have also evaluated the mechanical strength of only Cbz-FF-OH hydrogels formed through both heat−cool and sonication methods. Interestingly, upon comparing with the coassembled hydrogels, we observed a lower value of storage modulus for only Cbz-FF-OH hydrogels formed by both gelation pathways (Figure S4).…”

Hemostatic Tranexamic Acid-Induced Fast Gelation and Mechanical Reinforcement of Polydimethylacrylamide/Carboxymethyl Chitosan Hydrogel for Hemostasis and Wound Healing

“…In our previous work, we discovered that amino acids were capable of activating the potassium persulfate (KPS)− tetramethylethylenediamine (TMEDA) initiating system, enabling efficient decomposition and the introduction of multiple hydrogen bonds, thereby achieving rapid gelation and mechanical reinforcement of free-radical polymerized hydrogels. 20 Based on this research, utilizing amino acids or their derivatives as an initiating-cross-linking agent is expected to fabricate injectable hydrogels with excellent mechanical properties under mild conditions. Apart from the necessary mechanical properties, an ideal injectable hydrogel for hemostasis and wound healing should possess excellent adhesive performance, hemostatic ability, antibacterial activity, and wound-healing properties.…”

Low-Temperature Rapid Polymerization of Intrinsic Conducting PAD/OC Hydrogels with a Self-Adhesive and Sensitive Sensor for Outdoor Damage Repair and Detection

“…To resolve this defect, the hybrid physically chemically cross-linked networks are introduced into the hydrogels to construct sufficient cross-linking sites among the macromolecules . The dynamic characteristics of multiple sacrificial bonds, such as hydrogen bonds and electrostatic interactions, confer the amphiphilic hydrogels with excellent elasticity and fatigue resistance . Presently, natural polysaccharides and their derivatives with abundant hydroxyl and carboxyl groups are anticipated to be adopted as hybrid physically chemically cross-linked networks for preparing high-performance hydrogels. − Remarkably, curdlan, a natural polysaccharide with a unique stiff backbone of a triple-helical structure, exhibits interesting biological activities, gel properties, and abundant active hydroxyl groups conducive to forming dense dynamic hydrogen bonds and improving mechanical properties. − Despite its potential versatile virtues, the application of curdlan is limited by its low solubility.…”

“…48 To resolve this defect, the hybrid physically chemically cross-linked networks are introduced into the hydrogels to construct sufficient crosslinking sites among the macromolecules. 49 The dynamic characteristics of multiple sacrificial bonds, such as hydrogen bonds and electrostatic interactions, confer the amphiphilic hydrogels with excellent elasticity and fatigue resistance. 50 Presently, natural polysaccharides and their derivatives with abundant hydroxyl and carboxyl groups are anticipated to be adopted as hybrid physically chemically cross-linked networks for preparing high-performance hydrogels.…”