Amino acid induced self-assembled vesicles of choline oleate: pH responsive nano-carriers for targeted and localized delivery of doxorubicin for breast cancer

A dual responsive ionic liquid-based polymeric hydrogel: a promising drug delivery vehicle for the treatment of breast cancer

“…35,36 PVA is a hydrophilic, bio-degradable and bio-compatible polymer with lower mechanical strength and higher critical gelation concentration (above ∼12% w/v) that is not able to self-heal above 25% w/v. 37 To ameliorate this, in the present study we added choline oleate ([Ch][Ol]) beyond its cmc (1.7 mM), 7 where it is in its worm-like micellar form with >50 nm length, SANS data vide supra . Incorporation of [Ch][Ol] improves the gelation ability of PVA by decreasing the Critical Gelation Concentration (CGC) to 6% apart from its enhanced water retention ability, biocompatibility, self-healing ability and drug encapsulation as well as sustained release ability.…”

“…4,5 To address these limitations of the traditional treatment methods, localized drug delivery systems such as nanoparticles, coacervates, vesicles, and hydrogels are being explored as alternatives to deliver chemo drugs in a sustained and controlled manner. [6][7][8] Among them, injectable hydrogels have been explored for localized chemotherapy more frequently in recent times. 9,10 Among the studied hydrogels, peptide-based hydrogels show promising results in delivering drugs, proteins, and microRNAs, [11][12][13] but face challenges of low bioavailability, shorter half-life, and poor membrane permeability.…”

Sodium Chloride Induced pH and Temperature Responsive Biocompatible Hydrogel of Choline Oleate for Transdermal Drug Delivery of Doxorubicin

“…After removing fat layers, skin was cut into pieces of 1.5×1.5 cm and placed into two different Franz cells (one filled with pH 7.4 PBS and another with pH 5.2 PBS) with the SC facing upward and temperature was maintained 37 °C with a constant stirring magnetic bar. Then 0.5 mL of sample was placed in the donor compartment (on the outer side of the skin), and the donor compartment was covered with parafilm to prevent contamination from air [22] . A known amount from receiving phase was collected with a certain time intervals and monitored its UV‐vis spectra to quantify the concentration of drug released in receiving media.…”

“…Then 0.5 mL of sample was placed in the donor compartment (on the outer side of the skin), and the donor compartment was covered with parafilm to prevent contamination from air. [22] A known amount from receiving phase was collected with a certain time intervals and monitored its UV-vis spectra to quantify the concentration of drug released in receiving media. The transdermal flux was determined using the slope method, and the equation for calculating transdermal flux is (1),…”

Progress in the applications of biocompatible ionic liquids: renewable commodity production, catalytic and pharmaceutical approaches – a review

“…A remarkable number of recent studies have highlighted that the choline cation can provide a biodegradable and low toxicity Bio-IL. [41][42][43] Choline, sourced from natural origins, like meat and vegetable, represents one of the B-complex vitamins. 44 Among its numerous functions, such as muscle control and memory, it acts as a precursor to the neurotransmitter acetylcholine.…”