AMINO ACIDS | Metabolism

Ferreira, Ruben; Teixeira, A.

doi:10.1016/b0-12-227055-x/00040-7

Cited by 4 publications

(3 citation statements)

References 4 publications

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“…However, taking in consideration that ethanol was increased, further studies should make a trade-off between the dietary inclusion of rapeseed oil and the duration of such feeding regime as it seems to compromise the animal's health. The milk from goats fed with rapeseed oil had more 2-oxoglutaric acid, which is an intermediate in the tricarboxylic acid cycle and is the starting point in the formation of glutamate and the other members of the glutamate family ( 45 ). In high-yielding cows, glutamine has been proposed to be a limiting factor for milk protein synthesis ( 46 ).…”

Section: Discussionmentioning

confidence: 99%

Goat Milk Foodomics. Dietary Supplementation of Sunflower Oil and Rapeseed Oil Modify Milk Amino Acid and Organic Acid Profiles in Dairy Goats

Vargas‐Bello‐Pérez

Khushvakov

et al. 2022

Front. Vet. Sci.

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The dietary supplementation of vegetable oils is known to improve the dietary energy density as well as milk fatty acid profile; however, the impacts on the milk foodome is largely unknown. This study investigated the effect of two different sources of unsaturated fatty acids, rapeseed oil and sunflower oil, as a feeding supplement on the milk foodome from dairy goats. Nine Danish Landrace goats at 42 ± 5 days in milk were allocated to three treatment groups for 42 days with three animals per group. A control group received a basal diet made of forage and concentrate at an 85:15 ratio. On top of the basal diet, the second and third groups received rapeseed oil or sunflower oil supplements at 4% of dry matter, respectively. Goat milk was sampled on days 14, 21, and 42. The milk foodome was measured using gas chromatography–mass spectrometry and proton nuclear magnetic resonance spectroscopy. The milk levels of 2-hydroxyisovaleric acid, oxaloacetic acid, and taurine were higher in the milk from goats fed with sunflower oil compared to the control group. More glucose-1-phosphate was found in the milk from goats fed with rapeseed oil compared to the control group. Amino acids, valine and tyrosine, and 2-hydroxyisovaleric acid and oxaloacetic acid were higher in the sunflower group compared to the rapeseed group, while the milk from the rapeseed-fed goats had greater levels of ethanol and 2-oxoglutaric acid compared to the sunflower group. Thus, results show that foodomics is suitable for studying how milk chemistry changes as a function of feeding regime.

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Section: Discussionmentioning

confidence: 99%

Goat Milk Foodomics. Dietary Supplementation of Sunflower Oil and Rapeseed Oil Modify Milk Amino Acid and Organic Acid Profiles in Dairy Goats

Vargas‐Bello‐Pérez

Khushvakov

et al. 2022

Front. Vet. Sci.

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“…The urinary concentrations of tyrosine (Figure 5B) were significantly elevated in the TBM patients (55.09 ± 21.81 μmol/ mmol creatinine) compared to the controls (37.2 ± 20.14 μmol/ mmol creatinine; p = 0.021, d = 0.85). Phenylalanine and tyrosine are aromatic amino acids, synthesized from phosphoenolpyruvate and erythrose 4-phosphate-intermediates of glycolysis and the pentose phosphate pathway, respectively (Ferreira and Teixeira, 2003). Phenylalanine is catabolized into acetoacetic acid and fumaric Frontiers in Molecular Biosciences frontiersin.org acid via tyrosine (Komoda and Matsunaga, 2015).…”

Section: Perturbation Of Amino Acid Metabolismmentioning

confidence: 99%

Urinary metabolic characterization of advanced tuberculous meningitis cases in a South African paediatric population

Isaiah,

Loots,

van Reenen

et al. 2024

Front. Mol. Biosci.

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Tuberculous meningitis (TBM) is a severe form of tuberculosis with high neuro-morbidity and mortality, especially among the paediatric population (aged ≤12 years). Little is known of the associated metabolic changes. This study aimed to identify characteristic metabolic markers that differentiate severe cases of paediatric TBM from controls, through non-invasive urine collection. Urine samples selected for this study were from two paediatric groups. Group 1: controls (n = 44): children without meningitis, no neurological symptoms and from the same geographical region as group 2. Group 2: TBM cases (n = 13): collected from paediatric patients that were admitted to Tygerberg Hospital in South Africa on the suspicion of TBM, mostly severely ill; with a later confirmation of TBM. Untargeted 1H NMR-based metabolomics data of urine were generated, followed by statistical analyses via MetaboAnalyst (v5.0), and the identification of important metabolites. Twenty nine urinary metabolites were identified as characteristic of advanced TBM and categorized in terms of six dysregulated metabolic pathways: 1) upregulated tryptophan catabolism linked to an altered vitamin B metabolism; 2) perturbation of amino acid metabolism; 3) increased energy production–metabolic burst; 4) disrupted gut microbiota metabolism; 5) ketoacidosis; 6) increased nitrogen excretion. We also provide original biological insights into this biosignature of urinary metabolites that can be used to characterize paediatric TBM patients in a South African cohort.

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“…However, they can also be produced in other cellular compartments, including mitochondria, peroxisomes, and the cytosol [7,8]. Amino acids serve as both the building blocks and components of proteins, and they have a significant impact on metabolism and growth [9,10]. Assimilation of absorbed inorganic nitrogen into amino acids can occur in the roots and/or leaves.…”

Section: Introductionmentioning

confidence: 99%

Amino Acid Changes during Maturation in Solanum Fruit

Staveckienė,

Medveckienė,

Vaštakaitė-Kairienė

et al. 2024

Agriculture

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The goal of this study is to assess the impacts of ripening stage of four Solanum fruit species: (Solanum melanocerasum, Solanum nigrum, Solanum villosum, and Solanum retroflexum) on the content of amino acids and protein. Our objective is to enhance comprehension of the maturity process, with a particular focus on Solanum fruits, in order to determine the most advantageous time for harvesting. Amino acids play a crucial role in human nutrition by serving as building blocks for various primary and secondary metabolites. They are either a source of nutraceutical substances or important dietary components. The studied Solanum fruit’s amino acid profiles were found essential and nonessential amino acids. Our findings showed that dominant amino acids were nonessential amino acids. Depending on the ripening stage, the nonessential amino acid content of the Solanum melanocerasum fruits varied from 8.22 to 9.25 g 100 g−1, Solanum villosum from 5.34 to 6.60 g 100 g−1, Solanum nigrum from 6.12 to 8.73 g 100 g−1, and Solanum retroflexum from 8.27 to 9.75 g 100 g−1. A differentiated level of total protein is found in Solanum fruits at different ripening stages. The interval was from 10.62 to 28.06 g 100 g−1 depending on species or ripening stages.

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AMINO ACIDS | Metabolism

Cited by 4 publications

References 4 publications

Goat Milk Foodomics. Dietary Supplementation of Sunflower Oil and Rapeseed Oil Modify Milk Amino Acid and Organic Acid Profiles in Dairy Goats

Goat Milk Foodomics. Dietary Supplementation of Sunflower Oil and Rapeseed Oil Modify Milk Amino Acid and Organic Acid Profiles in Dairy Goats

Urinary metabolic characterization of advanced tuberculous meningitis cases in a South African paediatric population

Amino Acid Changes during Maturation in Solanum Fruit

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