2024
DOI: 10.1073/pnas.2407633121
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Amino acids modulate liquid–liquid phase separation in vitro and in vivo by regulating protein–protein interactions

Xufeng Xu,
Aleksander A. Rebane,
Laura Roset Julia
et al.

Abstract: Liquid–liquid phase separation (LLPS) is an intracellular process widely used by cells for many key biological functions. It occurs in complex and crowded environments, where amino acids (AAs) are vital components. We have found that AAs render the net interaction between proteins more repulsive. Here, we find that some AAs efficiently suppress LLPS in test tubes (in vitro). We then screen all the proteinogenic AAs and find that three specific AAs, including proline, glutamine, and glycine, significantly suppr… Show more

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