Amino Acids: Specific Functions

Poll, Marcel C.G. van de; Luiking, Y.C.; Dejong, C.H.C.; Soeters, Peter B.

doi:10.1016/b978-0-12-375083-9.00011-8

Cited by 7 publications

(3 citation statements)

References 2 publications

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“…[14] Lysine, an essential amino acid, promotes human growth and development, enhances immunity, and participates in the synthesis of proteins and maintaining of acid-base balance, being associated with glucose and fat metabolism. [15] Tyrosine is the precursor of a variety of bioactive substances, such as neurotransmitters, and it is closely related to the regulation of emotion. In addition, galactose metabolism is associated with amino acid metabolism, tricarboxylic acid cycle, and energy metabolism.…”

Section: Discussionmentioning

confidence: 99%

Effects of Danggui Wuji granules on 16S rDNA, metagenome, and metabolome in BDS mice

Huang,

Deng,

Chen

et al. 2024

Sci Tradit Chin Med

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Blood deficiency syndrome (BDS) refers to a pathological state with blood dysfunction and organ dystrophy in traditional Chinese medicine. Danggui Wuji granules (DWG) was developed from a formula containing Angelicae Sinensis Radix and Musculus et Os Galli Domestici. Herein, we investigated the mechanism of DWG in treating BDS by modulating gut microbiota. We found that DWG protected mice from BDS by elevating the levels of red blood cell count, hemoglobin, and hematocrit in peripheral blood and increasing the erythrocyte membrane Na+-K+-ATPase activity. Danggui Wuji granules changed the composition and metabolites of colonic flora. Notably, Lactobacillus, Muribaculaceae, and Alistipes were the main genera showing changes after DWG treatment. Our findings revealed that DWG presented a positive therapeutic effect on BDS in mice by regulating the gut microbiota and metabolites. The protective mechanism of DWG was associated with pathways such as metabolic pathways, biosynthesis of secondary metabolites, ABC transporters, ribosome, thyroid hormone synthesis, lysine degradation, galactose metabolism, tyrosine metabolism, etc.

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Section: Discussionmentioning

confidence: 99%

Effects of Danggui Wuji granules on 16S rDNA, metagenome, and metabolome in BDS mice

Huang,

Deng,

Chen

et al. 2024

Sci Tradit Chin Med

View full text Add to dashboard Cite

show abstract

“…Tryptophan is a precursor for the synthesis of serotonin, potentially impacting mood control (van de Poll et al, 2006) and appetite regulation (Fernstrom and Wurtman, 1972;Fernstrom and Fernstrom, 1995). These include their roles as neurotransmitters (e.g., glutamate, aspartate, and glycine) and as precursors for the synthesis of other molecules involved in neuromuscular function (e.g., creatine and taurine) and in host defenses (e.g., glutathione and nitric oxide).…”

Section: Milk Proteins As a Source Of Amino Acids-specific Physiologimentioning

confidence: 99%

“…Summaries of current evidence for proven functional effects (clinical benefits) in humans consequent upon dietary supplementation with specific amino acids have been provided by van de Poll et al (2006) and Jonker et al (2012). It is anticipated that over the next decade our understanding of the physiological roles of individual amino acids will increase, leading to opportunities to develop functional foods containing higher or lower amounts of certain amino acids.…”

Section: Milk Proteins As a Source Of Amino Acids-specific Physiologimentioning

confidence: 99%