Individuals from a subtidal, estuarine population of the common oyster drill, Urosalpinx cinerea (Say, 1822), were brought into the laboratory and tested for osmotic adjustment to changing salinity. Tissue variables monitored at seven experimental salinities ranging from 10 to 40% were tissue fluid osmolality, chloride, sodium, potassium, free amino acids (FAA), ninhydrin-positive substances (NPS) and water content. The results of this study demonstrate that the test animals did not exhibit anisosmotic regulation at any of the experimental salinities. However, the data do suggest a high degree of hyper-ionic regulation of potassium at all experimental salinities and a hyporegulation of sodium between the 25 and 40% salinities. Taurine, aspartic acid, alanine and glycine were the four FAA present in relatively consistent high amounts. These four amino acids comprised from 59.6 to 75.7% of the total FAA pools. It is postulated that the population does not maintain its euryhaline survival status through an osmoregulatory mechanism. Rather, the population has probably adapted physiologically to withstand dilution of its body fluids during spring conditions of low salinities.