Amino‐catalyzed fragmentation characteristics of polyamides containing N‐methylpyrrole and N‐methylimidazole by electrospray negative ionization mass spectrometry

Abstract

Different negative fragmentations of synthesized polyamides containing N-methylpyrrole and N-methylimidazole were analyzed by electrospray ionization tandem mass spectrometry with low-energy collision-induced dissociation. An interesting rearrangement derived from amino catalysis of N-methylimidazole was observed. The observation is useful for the study of the correlations between the sequences of polyamides and their mass fragmentation pathways.

Determination of pyrrole–imidazole polyamide in rat plasma by liquid chromatography–tandem mass spectrometry

“…In pharmacokinetic study, to investigate the pharmacokinetic characteristic for many hours, more sensitive methods like liquid chromatography-tandem mass spectrometry (LC-MS/MS) are required. Short and small polyamides of structure similar to that of Py-Im polyamide with N-methylpyrrole and N-methylimidazole were analyzed by LC-MS/MS [7][8][9]. However, in these analyses, the fragmentation of polyamide was mainly reported.…”