Aminocyclitols

Biosynthesis of cyclitols

“…Some of this family of enzymes have been extensively studied by the Mahmud group, and some excellent reviews have been published. 40,69–71,76,82–84 The Mahmud group has compared multiple DHQSs and this family of enzymes to describe the four types of substrate and potential product based on protein sequences. 69–71 Roscales and Plumet have also published a review concerning the biosynthesis of this family of carbasugars.…”

“…27). 40,84,125 In the validamycin biosynthesis, EEV is first epimerized by ValD to give 5- epi -valiolone, which is then dehydrated to yield valienone. 126,127 ValC catalyzes the phosphorylation of valienone to yield valienone 7-phosphate, which is considered the branching biosynthetic intermediate.…”