1979
DOI: 10.1016/s0022-3476(79)80394-7
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Aminoglycoside clearance inpatients with cystic fibrosis

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Cited by 62 publications
(23 citation statements)
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“…Thus, the ratio between the renal and total clearances of netilmicin in the CF patients in our study was 0.71. This is slightly lower than the ratio of 0.88 estimated from published data on amikacin (5), which has otherwise shown a similar pattern in CF and non-CF subjects, as was found for netilmicin in this study. The ratios between the total body clearances in CF and non-CF groups have been reported to be 1.26 for netilmicin and 1.14 for amnikacin (5).…”
Section: Discussioncontrasting
confidence: 60%
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“…Thus, the ratio between the renal and total clearances of netilmicin in the CF patients in our study was 0.71. This is slightly lower than the ratio of 0.88 estimated from published data on amikacin (5), which has otherwise shown a similar pattern in CF and non-CF subjects, as was found for netilmicin in this study. The ratios between the total body clearances in CF and non-CF groups have been reported to be 1.26 for netilmicin and 1.14 for amnikacin (5).…”
Section: Discussioncontrasting
confidence: 60%
“…This is slightly lower than the ratio of 0.88 estimated from published data on amikacin (5), which has otherwise shown a similar pattern in CF and non-CF subjects, as was found for netilmicin in this study. The ratios between the total body clearances in CF and non-CF groups have been reported to be 1.26 for netilmicin and 1.14 for amnikacin (5). Analogously, the distribution volumes for netilnicin were 12.6 liters for CF patients and 19.4 liters for non-CF patients and 16.0 and 14.9 liters, respectively, for amikacin in similar groups of children (5).…”
Section: Discussioncontrasting
confidence: 60%
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“…The aminoglycoside pharmacokinetics differ in CF patients as they show faster excretion and a greater volume of distribution than other patients (10,18,19). The aminoglycosides do not penetrate readily into the bronchial secretions (2), and the best response to tobramycin treatment in CF is seen when high doses are used (12,31) and when sputum concentrations are high (22).…”
Section: Discussionmentioning
confidence: 99%