Aminoguanidine and curcumin attenuated tumor necrosis factor (TNF)-α-induced oxidative stress, colitis and hepatotoxicity in mice

Mouzaoui, Souad; Rahim, Ibtissem; Djerdjouri, Bahia

doi:10.1016/j.intimp.2011.10.010

Cited by 78 publications

(55 citation statements)

References 58 publications

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“…Fourthly, curcumin inhibits CD4 + T-cell infiltration and NF-kB activation in colonic mucosa. Fifthly, curcumin manifests its effects against colitis by suppressing the expression of inflammatory cytokines such as TNF-a (Camacho- Barquero et al, 2007;Mouzaoui et al, 2012), IFN-g (Ung et al, 2010), IL-17 (Ung et al, 2010) and enzymes, such as p38 MAPK, iNOS, COX-2, myeloperoxidase and MMP-9, in the colonic mucosa (CamachoBarquero et al, 2007). Sixthly, curcumin has a therapeutic effect on DNBS-induced colitis in mice induced by its agonistic action on the vanilloid receptor TRPV1 (Martelli et al, 2007).…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

“…Curcumin failed to inhibit NF-kB in these mice, but when combined with IL-10, curcumin inhibited NF-kB quite effectively. Eighthly, curcumin decreases TNF-a-induced oxidative stress and colitis in mice (Mouzaoui et al, 2012). Ninthly, curcumin combined with resveratrol and simvastatin decreases acute small intestinal inflammation in mice by down-regulating the Th1-type immune response (Bereswill et al, 2010).…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

“…• Attenuated TNF-a-induced oxidative stress, acute colitis and hepatotoxicity in mice (Mouzaoui et al, 2012).…”

Section: Psoriasismentioning

confidence: 99%

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Curcumin: an orally bioavailable blocker of TNF and other pro‐inflammatory biomarkers

Aggarwal

Gupta

Sung

2013

British J Pharmacology

343

239

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TNFs are major mediators of inflammation and inflammation-related diseases, hence, the United States Food and Drug Administration (FDA) has approved the use of blockers of the cytokine, TNF-a, for the treatment of osteoarthritis, inflammatory bowel disease, psoriasis and ankylosis. These drugs include the chimeric TNF antibody (infliximab), humanized TNF-a antibody (Humira) and soluble TNF receptor-II (Enbrel) and are associated with a total cumulative market value of more than $20 billion a year. As well as being expensive ($15 000-20 000 per person per year), these drugs have to be injected and have enough adverse effects to be given a black label warning by the FDA. In the current report, we describe an alternative, curcumin (diferuloylmethane), a component of turmeric (Curcuma longa) that is very inexpensive, orally bioavailable and highly safe in humans, yet can block TNF-a action and production in in vitro models, in animal models and in humans. In addition, we provide evidence for curcumin's activities against all of the diseases for which TNF blockers are currently being used. Mechanisms by which curcumin inhibits the production and the cell signalling pathways activated by this cytokine are also discussed. With health-care costs and safety being major issues today, this golden spice may help provide the solution. LINKED ARTICLESThis article is part of a themed section on Emerging Therapeutic Aspects in Oncology. To view the other articles in this section visit http://dx

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Section: Inflammatory Bowel Diseasementioning

confidence: 99%

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

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Curcumin: an orally bioavailable blocker of TNF and other pro‐inflammatory biomarkers

Aggarwal

Gupta

Sung

2013

British J Pharmacology

343

239

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“…zThese substances can reduce the epithelial damage, improve the inflammation and increase the mucous layer that recovers the colonic mucosa devoid of the fecal stream [1][2][3] . Curcumin has been used as a substance for the prevention and treatment of many organ and tissue disorders, most of which are associated with inflammation and oxidative stress 33,34 . Curcumin alleviates oxidative stress due to its chemical structure functioning as a natural free radical scavenger reducing the inflammatory process in chronic diseases and regulates inflammatory and pro-inflammatory pathways related with colitis 14,34 .…”

mentioning

confidence: 99%

Claudin-3 and occludin content in the glands of colonic mucosa devoid from fecal stream submitted to topical intervention with oil extract of Curcuma longa

et al. 2017

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1 8-Experimental SurgeryActa Cir Bras. 2017;32(1):65-73 AbstractPurpose: To evaluate the inflammatory intensity and measure the tissue content of the proteins claudin-3 and occludin in the colonic mucosa without fecal stream submit to intervention with curcumin. Methods: Thirty-six rats were submitted to a proximal colostomy and a distal mucous fistula and divided into two groups according to sacrifice to be performed two or four weeks. Each group was divided into three subgroups according daily application of enemas containing saline, curcumin at 50 mg/kg/day or 200 mg/kg/day. Colitis was diagnosed by histological analysis. Claudin-3 and occludin were determined by immunohistochemistry. The tissue content of claudin-3 and occludin were quantified by computer-assisted image analysis. MannWhitney, Student t and ANOVA tests were used to analyze the results establishing the level of significance of 5% for both (p<0.05). Results: Curcumin at both concentrations reduces the inflammation and preserves the tissue content of the proteins claudin-3 and occludin, which was related to the concentration used and to the time of the intervention. Conclusion:The application of enemas with curcumin reduces inflammation and preserves the tissue content of the proteins claudin-3 and occludin in the colonic mucosa devoid from the fecal stream.

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“…Human and animal trials have shown that increased oxidative stress in the intestinal mucosa; activation of intracellular antioxidant enzymes such as glutathione peroxidase (GPx), myeloperoxidase (MPO), and superoxide dismutase (SOD) in the colonic mucosa; and reduced antioxidant levels are associated with IBDs (1,2). The upregulation of gut mucosal cytokines such as tumor necrosis factor-alpha (TNF-α) and oxidative stress have been related to IBDs such as UC and CD (3). Oxidative stress and oxidative cellular damage also play an important role in the pathogenesis of chronic UC and the associated carcinogenetic process (4).…”

Section: Introductionmentioning

confidence: 99%

Effects of glucagon-like peptide-2 on bacterial translocation in rat models of colitis

Halaçlar¹,

A²,

Ac³

et al. 2012

Turk J Gastroenterol

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Aminoguanidine and curcumin attenuated tumor necrosis factor (TNF)-α-induced oxidative stress, colitis and hepatotoxicity in mice

Cited by 78 publications

References 58 publications

Curcumin: an orally bioavailable blocker of TNF and other pro‐inflammatory biomarkers

Curcumin: an orally bioavailable blocker of TNF and other pro‐inflammatory biomarkers

Claudin-3 and occludin content in the glands of colonic mucosa devoid from fecal stream submitted to topical intervention with oil extract of Curcuma longa

Effects of glucagon-like peptide-2 on bacterial translocation in rat models of colitis

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