Aminolevulinic Acid Photodynamic Therapy in the Treatment of Erosive Pustular Dermatosis of the Scalp

Yang, Cheng‐San; Kuhn, Helena; Cohen, Lisa M.; Kroumpouzos, George

doi:10.1001/jamadermatol.2015.6300

Cited by 28 publications

(41 citation statements)

References 14 publications

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“…[24] Erosive pustulosis is another disease of the scalp that can be induced by EGFRI, and it is otherwise primarily seen in elderly people with atrophic Sun-damaged skin. [25] It is characterized by follicle-destroying pustules on the scalp. [26] There have been no studies performed regarding the association of TNF-α and any ILs in patients suffering from EGFRI-induced skin eruptions.…”

Section: Discussionmentioning

confidence: 99%

Extreme phenotype of epidermal growth factor receptor inhibitor-induced destructive folliculitis

et al. 2016

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Due to the increasingly widespread use and side effect profile of epidermal growth factor receptor inhibitors (EGFRIs), cutaneous side effects of these drugs are frequently encountered. The EGFR is expressed on keratinocytes and fibroblasts. Inhibition of EGFR can produce a range of cutaneous adverse effects, the most frequent being a characteristic acneiform skin eruption. As the latter is associated with good anti-neoplastic responses, the onset of EGFRI-induced acneiform skin eruption is typically viewed as a positive sign by patients and physicians. It can usually be treated well with standard acne drugs, but in rare cases, the skin eruption can be so severe that systemic therapy and/or interruption of EGFRI treatment are required. One of the severest forms of EGFRI-induced skin eruption occurring on the head and neck area resembles folliculitis decalvans. Here, we discuss the management of such a case seen in our department. In addition, we present an analysis of tumor necrosis factor-α, interleukin-1β (IL-1β), and IL-17A expression based on immunohistochemical stains and qPCR.

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Section: Discussionmentioning

confidence: 99%

Extreme phenotype of epidermal growth factor receptor inhibitor-induced destructive folliculitis

et al. 2016

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“…Photodynamic therapy (PDT) has both been shown to trigger and treat EPD [63,64]. A case series using aminolevulinic acid PDT was successful in treating 8 patients [65]. The authors of the study concluded that PDT with methyl aminolevulinate should be avoided because its increased lipophilic property and longer incubation period may have contributed to toxicity in their patients, thus triggering EPD.…”

Section: Treatmentmentioning

confidence: 99%

Erosive Pustular Dermatosis: A Manifestation of Immunosenescence A Report of 8 Cases

Thuraisingam

Mirmirani

2017

Skin Appendage Disord

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Erosive pustular dermatosis (EPD) is a rare condition of the scalp and legs that is marked by crusted erosions or superficial ulcerations that may result in scarring alopecia and chronic wounds. The condition predominantly affects elderly female as compared to male patients. Its pathogenesis remains poorly understood. The majority of the cases in the literature are from the United Kingdom and continental Europe. In this series, we present 8 North American patients with EPD of the scalp, one of whom also had involvement of the legs and another with the involvement of the face. All our patients were advanced in age and had a predisposition to chronic actinic damage, which are common characteristics of EPD previously reported in the literature. We hypothesize that immunosenescence leads to an aberrant immune response to wound healing and, along with other factors such as a loss of the normal epidermal barrier, ultraviolet damage, and hormonal factors, may contribute to the development of this condition.

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“…In instances when topical corticosteroids fail to resolve the lesions, which is thought to be due to the inability to penetrate hyperkeratosis crusts, a new treatment option has been discovered: curettage followed by aminolevulinic acid photodynamic therapy (PDT) [8]. Curettage is used to promote reepithelization within a week and the following treatment is characterized by a 1-hour application of 20% aminolevulinic acid and blue light (417 nm) exposure for 16 min 1–2 weeks later [8].…”

Section: Answermentioning

confidence: 99%

“…Curettage is used to promote reepithelization within a week and the following treatment is characterized by a 1-hour application of 20% aminolevulinic acid and blue light (417 nm) exposure for 16 min 1–2 weeks later [8]. In the 8 patients this treatment was assessed in, the lesions cleared after one round of treatment; in the other 2, two rounds successfully cleared the EPDS.…”

Section: Answermentioning

confidence: 99%

See 1 more Smart Citation

Chronic Crusted Scalp Lesion of an Elderly Male

Gamret

Fertig

Darwin

et al. 2017

Skin Appendage Disord

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Aminolevulinic Acid Photodynamic Therapy in the Treatment of Erosive Pustular Dermatosis of the Scalp

Cited by 28 publications

References 14 publications

Extreme phenotype of epidermal growth factor receptor inhibitor-induced destructive folliculitis

Extreme phenotype of epidermal growth factor receptor inhibitor-induced destructive folliculitis

Erosive Pustular Dermatosis: A Manifestation of Immunosenescence A Report of 8 Cases

Chronic Crusted Scalp Lesion of an Elderly Male

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