Aminolysis of epoxides catalyzed by three-dimensional, mesoporous titanosilicates, Ti-SBA-12 and Ti-SBA-16

Robust and Environmentally Benign Solid Acid Intercalation Catalysts for the Aminolysis of Epoxides

“…It should be noted that, when aliphatic amines, such as n ‐butylamine, is used instead of aniline to react with styrene oxide, we observed the lowest yield of β ‐amino alcohol production (entry 11). Similar behavior was observed in other reported catalytic systems, such as the titanosilicates, nanocrystalline Zr‐MFI etc . Moreover, when the terminal epoxides, such as epichlorohydrin and propene oxide instead of styrene oxide were reacted with aniline, the corresponding regio‐isomers A products were obtained at a conversion of 83 and 67 %, respectively (entry 12–13).…”

“…In addition, the adsorption ability and effective diffusion towards the active sites is an essential prerequisite in the case of heterogeneous bimolecular reactions between the reactants ,. To confirm our hypothesis, we conducted a series of competitive adsorption experiments in the presence of our catalyst.…”

YCl3-Catalyzed Highly Selective Ring Opening of Epoxides by Amines at Room Temperature and under Solvent-Free Conditions

“…This approach is usually met with some limitations such as kinetically slow reactions that may be due to inefficient activation of epoxides and low regioselectivity. To overcome these issues, many new catalytic methods have been introduced using various catalysts, with aims to enhance the electrophilicity of epoxides through metallic coordination or H-bonding [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. The N-alkylation of amines using cyclic carbonates is also an attractive approach to molecules under discussion [27,28].…”

A magnetic nanoparticle‐catalyzed regioselectivering opening of epoxides by aromatic amines

“…Aminolysis of epoxides with excess amine at elevated temperatures is a common synthetic tool for construction of β‐amino alcohols . High temperature may not be appropriate for certain complex and sensitive functional groups and, as a consequence, a variety of catalysts and promoters have been introduced for the cleavage of epoxides at room temperature . Even though these catalysts or promoters have improved the scope and yields of these reactions considerably, there are still some limitations with the method reported in the literature.…”