Aminomethylphosphonic acid alters amphibian embryonic development at environmental concentrations

Cheron, Marion; Brischoux, François

doi:10.1016/j.envres.2020.109944

Cited by 18 publications

(7 citation statements)

References 45 publications

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“…Additionally worthy of discussion, as seen in Table 2 , AMPA and glyphosate share a large number of effects in the animal models tested, from the more common effects associated with genotoxicity [ 84 ] and oxidative stress [ 111 ], to morphology and fecundity issues [ 110 ]. AMPA toxicity to humans is still largely understudied.…”

Section: In Vitro and In Vivo Studies To Assess Animal Toxicity (2010...mentioning

confidence: 99%

Glyphosate vs. Glyphosate-Based Herbicides Exposure: A Review on Their Toxicity

Martins-Gomes

Silva

Andreani

et al. 2022

JoX

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Glyphosate-based herbicide has been the first choice for weed management worldwide since the 1970s, mainly due to its efficacy and reported low toxicity, which contributed to its high acceptance. Many of the recent studies focus solely on the persistence of pesticides in soils, air, water or food products, or even on the degree of exposure of animals, since their potential hazards to human health have raised concerns. Given the unaware exposure of the general population to pesticides, and the absence of a significant number of studies on occupational hazards, new glyphosate-induced toxicity data obtained for both residual and acute doses should be analyzed and systematized. Additionally, recent studies also highlight the persistence and toxicity of both glyphosate metabolites and surfactants present in herbicide formulations. To renew or ban the use of glyphosate, recently published studies must be taken into account, aiming to define new levels of safety for exposure to herbicide, its metabolites, and the toxic excipients of its formulations. This review aims to provide an overview of recent publications (2010–present) on in vitro and in vivo studies aimed at verifying the animal toxicity induced by glyphosate, its metabolite aminomethylphosphonic acid (AMPA) and glyphosate-based formulations, evaluated in various experimental models. Apart from glyphosate-induced toxicity, recent data concerning the role of surfactants in the toxicity of glyphosate-based formulations are discussed.

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Section: In Vitro and In Vivo Studies To Assess Animal Toxicity (2010...mentioning

confidence: 99%

Glyphosate vs. Glyphosate-Based Herbicides Exposure: A Review on Their Toxicity

Martins-Gomes

Silva

Andreani

et al. 2022

JoX

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“…AMPA was the compound showing the highest prevalence, with a detection frequency of 88% and a median concentration of 44.2 ng L −1 . Although relatively low, this value is similar to those affecting the embryogenic development of amphibians [27] . GLY showed the highest maximum concentration, with a level above 30 0 0 ng L −1 in one of the streams draining the hilly vineyard area; however, the median value (26.9 ng L −1 ) and the percentage of positive samples for this compound (38%) remained below those obtained for AMPA.…”

Section: Occurrence Of Pesticides In Surface Water Samplesmentioning

confidence: 51%

Direct, automated and sensitive determination of glyphosate and related anionic pesticides in environmental water samples using solid-phase extraction on-line combined with liquid chromatography tandem mass spectrometry

López-Vázquez

Pérez-Mayán

Fernández-Fernández

et al. 2023

Journal of Chromatography A

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“…In aquatic organisms, the effects of AMPA exposure are controversial, ranging from low toxicity to numerous adverse effects, including increased mortality, development delay, increased morphological abnormalities, genotoxicity, increased oxidative stress, cardiac defects, hepatic inflammatory response or changes in metabolic activity (Antunes et al, 2017; Barreto et al, 2023; Cheron et al, 2022; Cheron and Brischoux, 2023, 2020; Guilherme et al, 2014; Ivantsova et al, 2022; Levine et al, 2015; Martins-Gomes et al, 2022; Matozzo et al, 2018; Tartu et al, 2022; Zhang et al, 2021). However, despite the numerous adverse effects reported on non-target organisms, AMPA is not under particular scrutiny, and the underlying mechanisms involved in its ecotoxicity are poorly identified.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies conducted on the spined toad, Bufo spinosus , have associated AMPA exposure with numerous adverse effects, such as higher embryonic and larval mortality, increased oxidative stress in tadpoles (Cheron et al, 2022; Cheron and Brischoux, 2023, 2020) and altered colouration in adult males (Tartu et al, 2023). In addition, in a companion study using the same individuals as the present one, we reported that environmentally relevant concentrations of AMPA (0.4 µg L -1 ) led to increased deformity rate upon hatching and increased development length, with effects depending on the habitat of origin of the parents (agricultural versus forest, Tartu et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Maternal body condition affects the response of larval spined toads’ faecal microbiome to a widespread contaminant

Tartu,

Pollet,

Clavereau

et al. 2023

Preprint

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Glyphosate’s primary metabolite, aminomethylphosphonic acid (AMPA) is the most detected pollutant in surface waters. Recent studies have raised concerns regarding its toxicity, yet the involved underlying mechanisms remain poorly understood. A disruption of the gut microbiome, which plays a crucial role in host health, could be the mediator of most adverse effects. We investigated the impact of AMPA exposure on the gut microbiome of spined toad tadpoles (Bufo spinosus). We hypothesized that AMPA could alter the gut microbiota composition and that these effects could depend on the microbiota source. We exposed tadpoles to minute concentrations of AMPA and analyzed their faecal microbiota using 16S rRNA gene sequencing as a proxy of the gut microbiota. AMPA exposure decreased the gut bacterial biomass and affected bacterial community composition of tadpole’s faeces. Furthermore, we observed interactions between AMPA exposure and maternal body condition on the Bacteroidota and Actinobacteriota phyla abundances. This suggests a maternal effect on early-life microbial colonizers that could influence the response of the gut microbiome to AMPA. These findings highlight the importance of considering the gut microbiome when studying the effects of environmental contaminants. Further research is needed to elucidate the long-term implications of this microbiome alteration for amphibian health.

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Aminomethylphosphonic acid alters amphibian embryonic development at environmental concentrations

Cited by 18 publications

References 45 publications

Glyphosate vs. Glyphosate-Based Herbicides Exposure: A Review on Their Toxicity

Glyphosate vs. Glyphosate-Based Herbicides Exposure: A Review on Their Toxicity

Direct, automated and sensitive determination of glyphosate and related anionic pesticides in environmental water samples using solid-phase extraction on-line combined with liquid chromatography tandem mass spectrometry

Maternal body condition affects the response of larval spined toads’ faecal microbiome to a widespread contaminant

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