(Aminophosphane)gold(I) and silver(I) complexes as antibacterial agents

Abstract

This manuscript describes the synthesis of new Au(I) and Ag(I) complexes with aminophosphane ligands and a study of their antibacterial activity against Gram-negative Salmonella enterica serovar typhimurium and Escherichia coli and Gram-positive Listeria monocytogenes and Staphylococcus aureus. The bactericidal assays revealed the effectiveness of these compounds on paradigm Gram-negative and Gram-positive pathogens, showing a moderate antimicrobial activity, comparable with the antibiotics of reference, for all gold(I) complexes and the silver(I) complexes without coordinated PPh3 groups. For those complexes that were found to show inhibitory activity, serial dilutions in liquid broth method were performed for determination of MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration).

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“…Their effectiveness is comparable to the reference antibiotics. The authors suggested that, due to the specific selectivity to Gram-positive versus Gram-negative bacteria of these complexes, the mechanism for their antibacterial action might be related to the inhibition of peptidoglycan synthesis in the cell wall [81].…”

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“…42 Recently, Ortego et al synthesized and characterized (aminophosphine)gold(I) and silver(I) complexes and evaluated them as antibacterial agents against Gram-negative Salmonella enterica serovar typhimurium and E. coli and Gram-positive L. monocytogenes and S. aureus. 19 They have observed moderate antimicrobial activity for all gold(I) complexes and the silver(I) derivatives without coordinated PPh 3 groups and suggested that the inhibition of peptidoglycan synthesis in the cell wall may be the mechanism of action of these complexes because of their specic selectivity to the Gram-positive versus Gram-negative bacteria. They also highlighted the inuence of the donor atoms coordinated to the metal center, however they did not examine cytotoxicity of these complexes.…”

“…They also highlighted the inuence of the donor atoms coordinated to the metal center, however they did not examine cytotoxicity of these complexes. 19 On the other hand, the cytotoxicity of gold(III) complexes towards MRC5 cell line has been previously examined, e.g. gold(III) complexes with the uoroquinolones antimicrobial agents noroxacin, levooxacin and sparoxacin have shown low cytotoxicity toward this cell line (IC 50 values in the range of 53-126 mM), 43 as well as gold(III) complexes with L-histidine-containing peptides (IC 50 > 100 mM) 24 and with esters of (S,S)-ethylenediamine-N,N 0 -di-2-propanoic acid (IC 50 ¼ 23.15-97.88 mM).…”

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“…Particularly, the antibacterial activity of some of these compounds is comparable with AgNO3. Gimeno et al reported the synthesis of new Au(I) complexes with aminophosphane ligands and studied their antibacterial activity against Gram-negative and Escherichia coli and Gram-positive pathogens [31]. The bactericidal assays reveal that these compounds show a moderate antimicrobial activity on model Gram-negative and Grampositive microorganisms and those in the absence of PPh3 moieties display significantly comparable bactericidal capabilities with the referencing antibiotics.…”