Aminophylline increases respiratory muscle activity during hypercapnia in humans

Yokoba, Masanori; Ichikawa, Tsuyoshi; Takakura, Akira; Ishii, Naohito; Kurosaki, Yoshifumi; Yamada, Yuya; Tsukushi, Tomoaki; Masuda, Noriyuki; Easton, Paul A.; Katagiri, Masayuki

doi:10.1016/j.pupt.2014.03.006

Cited by 23 publications

(15 citation statements)

References 41 publications

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“…Briefly, diaphragm EMG is a surrogate of respiratory effort [102, [111][112][113], it can be used to distinguish between central and obstructive sleep apnoea events [111,112,114], to assess exertional breathlessness during exercise [64,97,115,116] and, when combined with VT recordings, it can be used to assess upper airway resistance [112,117]. Given increased respiratory motor output to the respiratory muscles in COPD [118,119] and the relationship between EMG and lung function, respiratory EMG has been taken as a marker for disease severity in stable COPD [103] and to predict COPD exacerbations [105], early hospital admission [107] and the effect of medical interventions [120][121][122].…”

Section: Electromyographymentioning

confidence: 99%

ERS statement on respiratory muscle testing at rest and during exercise

et al. 2019

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Assessing respiratory mechanics and muscle function is critical for both clinical practice and research purposes. Several methodological developments over the past two decades have enhanced our understanding of respiratory muscle function and responses to interventions across the spectrum of health and disease. They are especially useful in diagnosing, phenotyping and assessing treatment efficacy in patients with respiratory symptoms and neuromuscular diseases. Considerable research has been undertaken over the past 17 years, since the publication of the previous American Thoracic Society (ATS)/European Respiratory Society (ERS) statement on respiratory muscle testing in 2002. Key advances have been made in the field of mechanics of breathing, respiratory muscle neurophysiology (electromyography, electroencephalography and transcranial magnetic stimulation) and on respiratory muscle imaging (ultrasound, optoelectronic plethysmography and structured light plethysmography). Accordingly, this ERS task force reviewed the field of respiratory muscle testing in health and disease, with particular reference to data obtained since the previous ATS/ERS statement. It summarises the most recent scientific and methodological developments regarding respiratory mechanics and respiratory muscle assessment by addressing the validity, precision, reproducibility, prognostic value and responsiveness to interventions of various methods. A particular emphasis is placed on assessment during exercise, which is a useful condition to stress the respiratory system.

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Section: Electromyographymentioning

confidence: 99%

ERS statement on respiratory muscle testing at rest and during exercise

et al. 2019

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“…This drug works clinically to centrally antagonize adenosine, which is a potent, endogenous central nervous system (CNS) depressant (13). When administered at the routine clinical therapeutic dose, aminophylline increases ventilation and the electromyography activity of both inspiratory and expiratory muscles (14). Several clinical studies have suggested that aminophylline can decrease the duration of recovery after total intravenous anesthesia with propofol and remifentanil, sevoflurane, and desflurane (15).…”

Section: Introductionmentioning

confidence: 99%

A Comparison of the Effects of Low and High Doses of Aminophylline on Recovery Time and the Bispectral Index Score Following Iso flurane Anesthesia

Imani

Tabatabaei

Moharari

et al. 2016

Iran Red Crescent Med J

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“…51,52 In addition to its bronchodilator and anti-inflammatory effects, theophylline stimulates the respiratory neuronal network 53,54 and increases the activity of respiratory muscles, including the intercostal and transversus abdominis muscles, as well as the diaphragm. [55][56][57] Taken together, these results suggest that theophylline may be therapeutic in patients with ventilator-induced diaphragmatic dysfunction-associated weaning difficulties. Theophylline was found to dose-dependently increase peak twitch tension in an in vitro model of isolated diaphragmatic fibers.…”

Section: Theophyllinementioning

confidence: 77%

Ventilator-Induced Diaphragmatic Dysfunction: Diagnosis and Role of Pharmacological Agents

Kim

Lim

2017

Respir Care

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The use of controlled mechanical ventilation results in a major reduction of diaphragmatic contractile force together with atrophy of diaphragm muscle fibers, which is a condition known as ventilator-induced diaphragmatic dysfunction. Ventilator-induced diaphragmatic dysfunction is one of the major contributors to weaning difficulties and even increased mortality. This review summarizes the current data on the pathogenesis and diagnosis of ventilator-induced diaphragmatic dysfunction, and it outlines the use of ultrasonography for diaphragm evaluation. In addition, current pharmacologic agents used to mitigate ventilator-induced diaphragmatic dysfunction are described, with a particular emphasis on the therapeutic potential of theophylline in patients with ventilator-induced diaphragmatic dysfunction-associated weaning difficulties.

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Aminophylline increases respiratory muscle activity during hypercapnia in humans

Cited by 23 publications

References 41 publications

ERS statement on respiratory muscle testing at rest and during exercise

ERS statement on respiratory muscle testing at rest and during exercise

A Comparison of the Effects of Low and High Doses of Aminophylline on Recovery Time and the Bispectral Index Score Following Iso flurane Anesthesia

Ventilator-Induced Diaphragmatic Dysfunction: Diagnosis and Role of Pharmacological Agents

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