Aminophylline-induced contractions of rabbit ear artery in high-K+ Ca2+-free medium

Manzini, Stefano; Maggi, Carlo Alberto; Meli, Alberto

doi:10.1111/j.2042-7158.1982.tb04222.x

Cited by 9 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In high-K+ Ca2+-free medium exposure of isolated ear arteries from HCD or RD rabbits to NA (0.1-5 pmol/1) produced a rapid and transient concentration-related vasoconstric tion strictly dependent upon mobilization of intracellular Ca2+ [13,14]. At low concentra tions NA was less effective on ear arteries from HCD as compared to RD-fcd rabbits ( fig.…”

Section: Effect O F Hcd On Na-and Kcl-lnduced Contractions O F Rabbitmentioning

confidence: 98%

High-Cholesterol Diet Induces Altered Responsiveness of Rabbit Arterial Smooth Muscle to Noradrenaline

Maggi¹,

Manzini²,

Grimaldi³

et al. 1985

Pharmacology

Self Cite

View full text Add to dashboard Cite

The potential effect of feeding a high-cholesterol atherogenic diet (HCD) on in vitro responsiveness of rabbit arterial smooth muscle was investigated. The vasoconstrictor response produced by either exogenous or endogenous (field stimulation) noradrenaline was significantly depressed in isolated segments of ear artery after HCD as compared to regular diet fed animals. On the other hand no changes to high K⁺ could be observed in arterial segments after HCD as compared to regular diet fed rabbits. In addition, the α-adrenoceptor-mediated inotropic response and contraction of bladder smooth muscle showed only minor or no changes after HCD as compared to regular diet fed rabbits.

show abstract

Section: Effect O F Hcd On Na-and Kcl-lnduced Contractions O F Rabbitmentioning

confidence: 98%

High-Cholesterol Diet Induces Altered Responsiveness of Rabbit Arterial Smooth Muscle to Noradrenaline

Maggi¹,

Manzini²,

Grimaldi³

et al. 1985

Pharmacology

Self Cite

View full text Add to dashboard Cite

show abstract

An Analysis of the Effects of Taurine on Cellular and Extracellular Calcium Mobilization in Rabbit Ear Artery

Manzini

Castellucci²,

Franconi

et al. 1987

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

An analysis of the effects of urethane on cardiovascular responsiveness to catecholamines in terms of its interference with Ca++ mobilization from both intra and extracellular pools

et al. 1984

View full text Add to dashboard Cite

Urethane (1 X 10(-2) - 1 X 10(-1) M) reduced, in a concentration-dependent manner, both intra and extracellular Ca++ dependent noradrenaline-induced contractions of perfused rabbit ear artery as well as the tonic contractions produced by perfusion with high K+ solution. However, a quantitative analysis of the data indicated that for urethane concentrations similar to those found in plasma during anesthesia urethane antagonism is confined to noradrenaline-induced contractions which depend upon the mobilization of Ca++ from intracellular storage sites. In KCl-contracted arteries, urethane enhanced the relaxant effects of isoprenaline. - Urethane reduced the amplitude of contractions of spontaneously beating guinea-pig right atrium at concentrations which have only a limited effect on frequency. In addition, it decreased in a concentration-dependent manner the amplitude of isoprenaline-activated electrically driven, and K+ depolarized guinea-pig right ventricular strips. Urethane had no effect on the chrono and inotropic actions of isoprenaline on cardiac preparations. In in vivo experiments the chronotropic response to low doses of isoprenaline was significantly higher in urethane-treated as compared to unanesthetized rats. The higher dose of isoprenaline tested produced a significant fall in systolic blood pressure in urethane-anesthetized rats. A significant correlation exists between the chronotropic response to isoprenaline and resting heart rate values in urethane-anesthetized rats. These results indicate that urethane, at concentrations similar to those found in plasma during anesthesia selectively interferes with mobilization of Ca++ from intracellular storage sites. In addition, the interference of urethane anesthesia with the isoprenaline chronotropic effect 'in vivo' cannot be explained by a direct interference of urethane with beta-adrenoceptors at cardiac level.

show abstract

Aminophylline-induced contractions of rabbit ear artery in high-K+ Ca2+-free medium

Cited by 9 publications

References 7 publications

High-Cholesterol Diet Induces Altered Responsiveness of Rabbit Arterial Smooth Muscle to Noradrenaline

High-Cholesterol Diet Induces Altered Responsiveness of Rabbit Arterial Smooth Muscle to Noradrenaline

An Analysis of the Effects of Taurine on Cellular and Extracellular Calcium Mobilization in Rabbit Ear Artery

An analysis of the effects of urethane on cardiovascular responsiveness to catecholamines in terms of its interference with Ca++ mobilization from both intra and extracellular pools

Contact Info

Product

Resources

About