Aminopropyl hybrid silica monolithic capillary containing mesoporous SBA-15 particles for in-tube SPME-HILIC-MS/MS to determine levodopa, carbidopa, benserazide, dopamine, and 3-O-methyldopa in plasma samples

Grecco, Caroline Fernandes; Miranda, Luís Felippe Cabral; Queiroz, Maria Eugênia Costa

doi:10.1016/j.microc.2020.105106

Cited by 25 publications

(11 citation statements)

References 67 publications

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“…Hybrid organic-inorganic monolith Organic-inorganic hybrid silica-based monoliths combine the advantages of organic polymers (pH stability and good biocompatibility) and silica-based monoliths (high mechanical strength, high permeability, and good tolerance to organic solvent) [106]. Incorporation of different organic functional moieties into inorganic silica monolithic capillaries via the sol-gel process has afforded various organic-inorganic hybrid monoliths with different organic functionalities including C18-phenyl [107], cyano [108], amino [109], and cyano-amino [35] with distinct macromesoporous structures for application in in-tube SPME [106]. Domingues et al [108] prepared an organic-inorganic hybrid cyanopropyl monolithic capillary column with high permeability and low backpressure, which facilitated biological sample percolation.…”

Section: 9mentioning

confidence: 99%

“…Grecco et al [109] evaluated incorporation of mesoporous Amorphous Silica (SBA-15) particles into a hybrid organic-inorganic monolith, to combine the advantages of the two materials. SBA-15 silica particles with highly ordered mesopores presents high surface area, extremely narrow pore size distribution, and perfectly adjustable pore size.…”

Section: 9mentioning

confidence: 99%

“…Effect of (A) injection volume; (B) flow rate of postcolumn infusion (acetonitrile solution containing 3% formic acid). Reprinted with permission from[109] …”

mentioning

confidence: 99%

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Novel materials as capillary coatings for in‐tube solid‐phase microextraction for bioanalysis

Grecco

Souza

Queiroz

2021

J of Separation Science

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In-tube solid-phase microextraction with a capillary column as extraction device can be directly coupled with high-performance liquid chromatography systems (HPLC). The in-tube solid-phase microextraction technique has been continuously developed since it was introduced in 1997. New couplings have also been evaluated on the basis of state-of-the-art HPLC instruments. Different types of capillaries (wall-coated open tubular, porous layer open tubular, sorbent-packed, porous monolithic rods, or fiber-packed) with selective stationary phases (monoliths, magnetic nanoparticles, conducting polymers, restricted access materials, ionic liquids, carbon, deep eutectic solvents, and hybrid materials) have been developed to boost in-tube solid-phase microextraction performance (sorption capacity and selectivity). This technique has been successfully applied to analyze biological samples (serum, plasma, whole blood, hair, urine, milk, skin, and saliva) for therapeutic drug monitoring, to study biomarkers, to detect illicit drugs, to conduct metabolomics studies, and to assess exposure to drugs. This review describes current advances in in-tube solid-phase microextraction extraction devices and their application in bioanalysis. K E Y W O R D Sbioanalysis, capillary coatings, in-tube solid-phase microextraction, online systems INTRODUCTIONBioanalysis is a subdiscipline of analytical chemistry that quantitatively measures xenobiotics (chemically

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Section: 9mentioning

confidence: 99%

Section: 9mentioning

confidence: 99%

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Novel materials as capillary coatings for in‐tube solid‐phase microextraction for bioanalysis

Grecco

Souza

Queiroz

2021

J of Separation Science

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“…In addition, silicon-based materials also have high mechanical strength and stability. All these ensure that the chromatographic column prepared by silicon-based materials has the advantages of wide range of application, good reproducibility, high stability, high column efficiency, low resistance, and so on [ 4 , 5 , 6 , 7 ]. However, the preparation process of silicon-based materials is complex, and the manufacturing cost is high.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Nano-Fe3O4 and Its Application for C18-Functionalized Magnetic Nanomaterials Used as Chromatographic Packing Materials

Liu

Zhou

et al. 2023

Nanomaterials

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A new type of magnetic nanomaterial with Fe3O4 as the core and organic polymer as the shell was synthesized by seed emulsion polymerization. This material not only overcomes the problem of insufficient mechanical strength of the organic polymer, it also solves the problem that Fe3O4 is prone to oxidation and agglomeration. In order to make the particle size of Fe3O4 meet the requirement of the seed, the solvothermal method was used to prepare Fe3O4. The effects of the reaction time, amount of solvent, pH value, and polyethylene glycol (PEG) on the particle size of Fe3O4 were investigated. In addition, in order to accelerate the reaction rate, the feasibility of preparing Fe3O4 by microwave was studied. The results showed that under the optimum conditions, the particle size of Fe3O4 could reach 400 nm and had good magnetic properties. After three stages of oleic acid coating, seed emulsion polymerization, and C18 modification, the obtained C18-functionalized magnetic nanomaterials were used for the preparation of the chromatographic column. Under optimal conditions, stepwise elution significantly shortened the elution time of sulfamethyldiazine, sulfamethazine, sulfamethoxypyridazine, and sulfamethoxazole while still achieving a baseline separation.

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“…Inorganic polymers are commonly based on silica and are widely used as a stationary phase. Several kinds of research have been reported in terms of application of inorganic polymers, such as separation and detection of cation levels in drinking water , protein (Zhao et al, 2012), tryptic digests of bovine serum albumin (BSA) (Zhang et al, 2011), levodopa, carbidopa, benserazide, dopamine, and 3-O-methyldopa in plasma samples (Grecco et al, 2020), polar compounds (Yang et al, 2013) and other macromolecular compounds (Iwasaki et al, 2012). However, time-consuming manufacturing and a limited variety of polymer-forming materials were obtained as disadvantages of inorganic polymer (Zhong et al, 2010, Lalli et al, 2020.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Organic Polymer Monolith Columns Containing Ammonium Quarternary As Initial Study For Capillary Chromatography

Rahayu

Jamilatun

Fajri

et al. 2021

EKW

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The polymerization process with a simple step has become the centre of attention of several researchers. Various polymers have been developed, although in general, they use polymerization with a post-modification method. A quaternary ammonium monolith organic polymer has been prepared using a simple single thermal method in this research. 2-(Methacryloyloxy)-N,N,N-trimethylethanaminium chloride was as the monomer, and ethylene dimethacrylate was as crosslinker. The polymerization proceeded in fused-silica capillary (100 mm, 0.32 mm i.d. x 0.45 mm o.d.) using a one-pot approach method. To achieve the perfect macropores, isopropyl alcohol, PEG 400, and ethanol were used as porogen. Characterization of the surface morphology was carried out using a Scanning Electron Microscope (SEM), and the existence of an amine group was characterized by Fourier Transform Infrared Spectroscopy (FTIR). The distribution size of pores in the polymer was in the range of 1.29 to 3.33 µm.Abstrak: Polimerisasi dengan proses yang sederhana dan simpel menjadi pusat perhatian beberapa peneliti. Berbagai macam polimer telah dikembangkan, akan tetapi pada umumnya menggunakan polimerisasi dengan metode post-modification. Pada penelitian ini, polimer organik yang mengandung amonium kuartener dalam bentuk monolit dengan polimerisasi yang menggunakan suhu tunggal dan sederhana telah dilakukan. 2-(Methacryloyloxy)-N,N,N-trimethylethanaminium chloride digunakan sebagai monomer dan ethylene dimethacrylate sebagai crosslinker. Polimerisasi dilakukan dengan metode one-pot aaproach di dalam kapiler silika (100 mm, 0,32 mm i.d. x 0,45 mm o.d.). Untuk mendapatkan makropori yang sempurna, isopropil alkohol, PEG 400 dan etanol digunakan sebagai porogen. Karakterisasi morfologi permukaan dilakukan dengan menggunakan Scanning Electron Microscope (SEM), dan Fourier Transform Infrared Spectroscopy (FTIR) untuk mengidentifikasi gugus fungsi gugus amina yang terdapat pada polimer. Ukuran distribusi pori pada polimer berkisar antara 1,29 sampai 3,33 µm.

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Aminopropyl hybrid silica monolithic capillary containing mesoporous SBA-15 particles for in-tube SPME-HILIC-MS/MS to determine levodopa, carbidopa, benserazide, dopamine, and 3-O-methyldopa in plasma samples

Cited by 25 publications

References 67 publications

Novel materials as capillary coatings for in‐tube solid‐phase microextraction for bioanalysis

Novel materials as capillary coatings for in‐tube solid‐phase microextraction for bioanalysis

Preparation and Characterization of Nano-Fe3O4 and Its Application for C18-Functionalized Magnetic Nanomaterials Used as Chromatographic Packing Materials

Characterization of Organic Polymer Monolith Columns Containing Ammonium Quarternary As Initial Study For Capillary Chromatography

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