Aminopyrifen, a novel 2-aminonicotinate fungicide with a unique effect and broad-spectrum activity against plant pathogenic fungi

Abstract

Aminopyrifen is a novel 2-aminonicotinate fungicide with unique chemistry and a novel mode of action. The fungicide showed high antifungal activity mainly against Ascomycetes and its related anamorphic fungi under in vitro and pot conditions (EC 50 values: 0.0039-0.23 mg/L and 1.2-12 mg/L, respectively). The active ingredient strongly inhibited germ-tube elongation of Botrytis cinerea below 0.1 mg/L and invasion into a plant. The compound exhibited no cross-resistance to commercial fungicides in B. cinerea. The antifungal agent showed high preventive efficacy and translaminar action. In the field, aminopyrifen controlled gray mold and powdery mildew at 150 mg/L. Our findings suggest that aminopyrifen is useful for protecting crops from various plant pathogens.

Elevated mutation rates in the multi-azole resistantAspergillus fumigatusclade drives rapid evolution of antifungal resistance

“…However, a number of agricultural antifungals have either been approved or are in late development for use in crop protection that share the same mechanism of action as these novel clinical drugs ( 51 ). The pyridine fungicide aminopyrifen ( 52 ) targets the same enzyme, GWT-1, as fosmanogepix. Likewise, ipflufenoquin which has been approved by the US Environmental Protection Agency for agricultural use ( 53 ) is analogous to the dihydroorotate dehydrogenase (DHODH) inhibitor olorofim.…”

To each its own: Mechanisms of cross-talk between GPI biosynthesis and cAMP-PKA signaling in Candida albicans versus Saccharomyces cerevisiae

“…and Scedosporium sp., are reported ( 39 , 40 ). Hence, as mentioned in the introduction, this step has been the intense focus of research for the development of antifungals and fungicides ( 5 , 6 , 41 ).…”

Trendbericht Organische Chemie 2023

“…Beispiele sind Aminopyrifen (142a), Flufenoxadiazam (142b), und Ipflufenoquin (142c). Während das Pyridinfungizid (142a) in die Glycosylphosphatidylinositol-Biosynthese (GPI) eingreift und vorwiegend gegen Grauschimmel wirkt, 123) inhibiert das Oxadiazolfungizid (142b) das Enzym Histondeacetylase (HDAC) und wird zur Kontrolle von Rostpilzen entwickelt. 124,125) 127) Insgesamt sechs neue insektizide Wirkstoffe wurden im Jahr 2022 bekannt gemacht.…”