Aminothiazole derivatives with antidegenerative activity on cartilage

Panico, Annamaria; Geronikaki, Athina; Mgonzo, Remi; Cardile, Venera; Gentile, Barbara Cristina; Doytchinova, Irini

doi:10.1016/s0968-0896(03)00149-4

Cited by 30 publications

(10 citation statements)

References 14 publications

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“…The spectral band at 223 nm was assigned to transition motions of phenyl rings. The transition band at 273 nm corresponded to n-π* transition of hydroxyl group [22,23]. The bands at 223 and 289 nm for GFS and 1,10-phenanthroline, respectively, are related to the π-π* transitions of the pyridine and benzene rings [24].…”

Section: Uv-visible Studiesmentioning

confidence: 96%

Ternary metal complexes of guaifenesin drug: Synthesis, spectroscopic characterization and in vitro anticancer activity of the metal complexes

Mahmoud

El‐Sonbati

et al. 2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Section: Uv-visible Studiesmentioning

confidence: 96%

Ternary metal complexes of guaifenesin drug: Synthesis, spectroscopic characterization and in vitro anticancer activity of the metal complexes

Mahmoud

El‐Sonbati

et al. 2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…Thiazoles and their derivatives form a part of vitamin B 1 and coenzyme carboxylase (Schrauzer and Kohnle, 1964). They represent a very interesting class of compounds because of their wide applications as antimicrobial (Chohan et al, 2003;Vicini et al, 2003), anti-inflammatory , anti-degenerative (Panico et al, 2003) and anti-HIV (Maass et al, 1993) activities. In continuation of our work on thiazole derivatives (Amir and Azam, 2004a) and Schiff bases (Amir and Azam, 2004b) we have synthesized new Schiff bases of naphtha[1,2-d]thiazol-2-amine purposely to combine the lipophilicity of naphthalene moiety to enhance membrane permeability with thiazole ring and azomethine linkage to study their effect on pathogenic strains of Gram positive and Gram negative bacteria.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Schiff bases of naphtha[1,2-d]thiazol-2-amine and metal complexes of 2-(2′-hydroxy)benzylideneaminonaphthothiazole as potential antimicrobial agents

Azam

Singh

Khokhra

et al. 2007

J. Zhejiang Univ. - Sci. B

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Abstract:Objective: A series of 2-benzylideneaminonaphthothiazoles were designed and synthesized incorporating the lipophilic naphthalene ring to render them more capable of penetrating various biomembranes. Methods: Schiff bases were synthesized by the reaction of naphtha[1,2-d]thiazol-2-amine with various substituted aromatic aldehydes. 2-(2'-Hydroxy)benzylideneaminonaphthothiazole was converted to its Co(II), Ni(II) and Cu(II) metal complexes upon treatment with metal salts in ethanol. All the compounds were evaluated for their antibacterial activities by paper disc diffusion method with Gram positive Staphylococcus aureus and Staphylococcus epidermidis and Gram negative Escherichia coli and Pseudomonas aeruginosa bacteria. The minimum inhibitory concentrations of all the Schiff bases and metal complexes were determined by agar streak dilution method. Results: All the compounds moderately inhibited the growth of Gram positive and Gram negative bacteria. In the present study among all Schiff bases 2-(2'-hydroxy)benzylideneaminonaphthothiazole showed maximum inhibitory activity and among metal complexes Cu(II) metal complex was found to be most potent. Conclusion: The results obtained validate the hypothesis that Schiff bases having substitution with halogens, hydroxyl group and nitro group at phenyl ring are required for the antibacterial activity while methoxy group at different positions in the aromatic ring has minimal role in the inhibitory activity. The results also indicated that the metal complexes are better antibacterial agents as compared to the Schiff bases.

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“…Due to increasing of microbial resistance towards the existing antibiotics, new chemical compounds have been synthesized by thiazole with different aromatic substituted with a wide range of biological activities such as anticancer [3][4][5], antibacterial [6], antifungal [7], anti-inflammatory [8], antitubercular [9], cardiotonic [10] and antidegenerative activity on cartilage [11] etc. Already, we synthsised Alkyl 2-(Dialkylamino)-4 phenylthiazole-5-carboxylates derivatives (6a-4l) in good yields [12].…”

Section: Introductionmentioning

confidence: 99%