Aminotransferases disorders associated with venous thromboembolic events in patients infected with COVID-19

Hamadé, A.; Woehl, Bastien; Talbot, Marjolaine; Bensalah, N.; Michel, P.-L.; Obringer, G.; Lehn-Hogg, M.; Buschenrieder, Nathalie; Issa, Mahdi; Tousch, Jonathan; Stephan, Dominique; Jambert, Lucas

doi:10.1016/j.aohep.2020.10.002

Cited by 4 publications

(4 citation statements)

References 16 publications

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“…The probable reason for the low detection rate of thrombosis in our study population was that lower extremity ultrasound was not performed routinely in all our patients, but only for those with clinical signs of thrombosis or a significant increase in D-dimer. On the other hand, Hamadé et al, 20 studied only 46 patients against our 828, giving our results greater statistical power.…”

Section: Discussionmentioning

confidence: 61%

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Clinical Outcome and Risk Assessment in Hospitalized COVID-19 Patients with Elevated Transaminases and Acute Kidney Injury: A Single Center Study

Khruleva¹,

Kobalava²,

Arisheva³

et al. 2022

Oman Med J

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Objectives: Initial reports indicate a high incidence of abnormal aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in patients with COVID-19 and possible association with acute kidney injury (AKI). We aimed to investigate clinical features of elevated transaminases on admission, its association with AKI, and outcomes in patients with COVID-19. Methods: A retrospective analysis of the registered data of hospitalized patients with laboratory-confirmed COVID-19 and assessment of the AST and ALT was performed. Multinomial logistic regression was used to determine factors associated with community-acquired AKI (CA-AKI) and hospital-acquired AKI (HA-AKI). Results: The subjects comprised 828 patients (mean age = 65.0±16.0 years; 51.4% male). Hypertension was present in 70.3% of patients, diabetes mellitus in 26.0%, and chronic kidney disease in 8.5%. In-hospital mortality was 21.0%. At admission, only 41.5% of patients had hypertransaminasemia. Patients with elevated transaminases at admission were younger, had higher levels of inflammatory markers and D-dimer, and poorer outcomes. The AKI incidence in the study population was 27.1%. Patients with hypertransaminasemia were more likely to develop AKI (33.5% vs. 23.3%, p =0.003). Patients with predominantly elevated AST (compared to elevated ALT) were more likely to have adverse outcomes. Multinomial logistic regression found that hypertension, chronic kidney disease, elevated AST, and hematuria were associated with CA-AKI. Meanwhile, age > 65 years, hypertension, malignancy, elevated AST, and hematuria were predictors of HA-AKI. Conclusions: Elevated transaminases on admission were associated with AKI and poor outcomes. Patients with elevated AST were more likely to have adverse outcomes. Elevated AST on admission was associated with CA-AKI and was a predictor of HA-AKI.

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Section: Discussionmentioning

confidence: 61%

“…The possible relationship between hypercoagulation and hypertransaminasemia is discussed in the work of Hamadé et al, 20 which retrospectively shows a potential association between elevated transaminases and venous thrombosis. Our study found no similar associations.…”

Section: Discussionmentioning

confidence: 99%

Clinical Outcome and Risk Assessment in Hospitalized COVID-19 Patients with Elevated Transaminases and Acute Kidney Injury: A Single Center Study

Khruleva¹,

Kobalava²,

Arisheva³

et al. 2022

Oman Med J

View full text Add to dashboard Cite

show abstract

“…Recently, Amer and his colleagues published an interesting study entitled “Aminotransferases disorders associated with venous thromboembolic events in patients infected with COVID-19” in Annals of Hepatology [ 1 ]. In this retrospective study, the authors explored the association between venous thromboembolic (VTE) events and elevated aminotransferases (AT) in patients infected with COVID-19.…”

mentioning

confidence: 99%