Amiodarone increases positive-strand RNA virus replication<i>in vitro</i>: implications for its use in patients with viral infections: Table 1.

Salata, Cristiano; Munegato, Denis; Elena, Piccoli; Calistri, Arianna; Parolin, Cristina; Mirazimi, Alì; Baritussio, Aldo; Palù, Giorgio

doi:10.1093/jac/dkv305

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…Interestingly, amiodarone also inhibits the infection of additional viruses, that is, the New World arenavirus Guanarito, the SARS-CoV, and HCV [40,63,64]. However, viruses as the Old World arenavirus Lassa, the Rhabdoviridae (vesicular stomatitis virus -VSV, and rabies), Bunyaviridae (Hantaan and Crimean-Congo Hemorrhaging Fever virus -CCHFV) and Dengue are not inhibited, at least under the tested conditions [40,65,66]. An in vitro strong antiviral activity against EBOV has also been reported for the calcium channel blocker bepridil.…”

Section: Antiarrhythmics Drugsmentioning

confidence: 98%

“…Finally, despite CADs display a wide range of antiviral effects, surprisingly some reports described a positive effect of specific CADs on replication of certain viruses. For instance, Salata et al [66] reported that amiodarone significantly increases enteroviral progeny release from infected cells in vitro, while Wu et al [105] described an increase of influenza A virus A/WSN/33 (H1N1) replication in human lung epithelial cells A549, after treatment with chloroquine. Klintworth and coworkers [65] reported that, while amiodarone and other CADs do not affect the entry of wild type rabies virus into target cells, the same molecules enhance entry of lentiviral particles pseudotyped with the rabies virus envelope glycoprotein into non-neuronal cells.…”

Section: Expert Commentarymentioning

confidence: 99%

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Antiviral activity of cationic amphiphilic drugs

Salata

Calistri

Parolin

et al. 2017

Expert Review of Anti-infective Therapy

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124

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Emerging and reemerging viral infections represent a major concern for human and veterinary public health and there is an urgent need for the development of broad-spectrum antivirals. Areas covered: A recent strategy in antiviral research is based on the identification of molecules targeting host functions required for infection of multiple viruses. A number of FDA-approved drugs used to treat several human diseases are cationic amphiphilic drugs (CADs) that have the ability to accumulate inside cells affecting several structures/functions hijacked by viruses during infection. In this review we summarized the CADs' chemical properties and effects on the cells and reported the main FDA-approved CADs that have been identified so far as potential antivirals in drug repurposing studies. Expert commentary: Although there have been concerns regarding the efficacy and the possible side effects of the off-label use of CADs as antivirals, they seem to represent a promising starting point for the development of broad-spectrum antiviral strategies. Further knowledge about their mechanism of action is required to improve their antiviral activity and to reduce the risk of side effects.

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Section: Antiarrhythmics Drugsmentioning

confidence: 98%

Section: Expert Commentarymentioning

confidence: 99%

Antiviral activity of cationic amphiphilic drugs

Salata

Calistri

Parolin

et al. 2017

Expert Review of Anti-infective Therapy

Self Cite

124

123

View full text Add to dashboard Cite

show abstract

“…There is evidence that cationic amphiphilic drugs should be studied for possible interference with the life cycle of positive-stranded RNA viruses [ 12 ]. Specifically, the cationic amphiphilic drug amiodarone and its major metabolite N -desethylamiodarone ( N -DEA) inhibit the entry of filoviruses (a family that includes Ebola virus) at similar concentrations to those found in the blood of patients treated for arrhythmias [ 13 ].…”

Section: Rationale For Amiodarone Usementioning

confidence: 99%

Amiodarone in the COVID-19 Era: Treatment for Symptomatic Patients Only, or Drug to Prevent Infection?

Sanchís-Gomar

Lavie

Morin

et al. 2020

Am J Cardiovasc Drugs

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Amiodarone, one of the most widely prescribed antiarrhythmic drugs to treat both ventricular and supraventricular arrhythmias, has been identified as a candidate drug for use against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We present the rationale of using amiodarone in the COVID-19 scenario, as well as whether or not amiodarone administration represents a potential strategy to prevent SARS-CoV-2 infection, rather than simply used to treat patients already symptomatic and/or with severe coronavirus disease 2019 (COVID-19), based on current evidence.

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Small-molecule and Synthetically Derived Antivirals for Ebola Virus and Other Filoviruses

Iversen

Bixler

Kane

et al. 2021

Antiviral Discovery for Highly Pathogenic Emerging Viruses

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Filoviruses—Ebola virus (EBOV), Marburg virus, and Sudan virus—are human pathogenic viruses, outbreaks of which have been associated with high case fatality rates. No antivirals have been approved to combat filovirus disease. Multiple experimental therapeutics have been shown to protect nonhuman primates against filovirus infection, and recent EBOV outbreaks have provided opportunities for clinical efficacy evaluations of promising investigational products. This chapter provides a comprehensive review of small molecules and other synthetic entities that have shown potential as therapeutic agents to combat filovirus disease. Summarized results are intended to convey key results from in vitro, in vivo, or clinical antiviral assessments; known mechanism(s) of action; and other relevant pharmacological characterizations of therapeutic candidates.

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Amiodarone increases positive-strand RNA virus replicationin vitro: implications for its use in patients with viral infections: Table 1.

Cited by 3 publications

References 8 publications

Antiviral activity of cationic amphiphilic drugs

Antiviral activity of cationic amphiphilic drugs

Amiodarone in the COVID-19 Era: Treatment for Symptomatic Patients Only, or Drug to Prevent Infection?

Small-molecule and Synthetically Derived Antivirals for Ebola Virus and Other Filoviruses

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