Amiodarone-Induced Thyroid Dysfunction

Leo, Simone De; Braverman, Lewis E.

doi:10.1007/978-3-319-72102-6_30

Cited by 5 publications

(1 citation statement)

References 100 publications

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“…Дифференциальная диагностика между 1 и 2 типом амиодарон-индуцированного тиреотоксикоза (АИТ) является сложной задачей, поскольку не существует оптимального высокоспецифичного диагностического теста [32].…”

Section: сцинтиграфия в норме и при различной диффузной и/или узловой патологии щжunclassified

Thyroid scintigraphy in diagnosis of nodular and diffuse thyroid pathology

Rumyantsev¹,

Degtyarev²,

Dzeytova³

et al. 2020

Clin Exp Thyroid

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Diagnosis of the causes of thyrotoxicosis (destruction or increased functional activity of the thyroid tissue in nodular and diffuse thyroid pathology) is a key point in determining the management of patients with this pathology. Scintigraphy is the method of choice in differential diagnosis of the causes of thyrotoxicosis assessing the functional state of the thyroid gland. According to variable medical interest, thyroid scintigraphy can be performed using 99mTc-pertechnetate or radioactive iodine isotopes (123I, 124I, 131I). For thyroid uptake evaluation used scintigraphy with 99mTc-pertechnetate radiopharmaceutical, which is not organificates and quickly excretes from thyroid tissue. In case of thyroid iodine pharmacokinetics investigation radiopharmaceuticals labeled by iodine isotopes (123I,131I, 124I) are used. The review includes original scintigrams, tables and diagrams. Article shows thyroid scintigraphy informativity analysis, evaluates the place and role of the thyroid scintigraphy examinations in modern diagnostic algorithms taking into account the history of the disease, laboratory tests, ultrasound (TIRADS) and result ofFNA (Bethesda). Additionally authors focused on existing clinical guidelines analysis. An optimized algorithm for the diagnosis and treatment of diffuse and/or nodular thyroid pathology associated with thyrotoxicosis is proposed.

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Section: сцинтиграфия в норме и при различной диффузной и/или узловой патологии щжunclassified

Thyroid scintigraphy in diagnosis of nodular and diffuse thyroid pathology

Rumyantsev¹,

Degtyarev²,

Dzeytova³

et al. 2020

Clin Exp Thyroid

View full text Add to dashboard Cite

show abstract

Recent Developments in C−H Functionalisation of Benzofurans and Benzothiophenes

2020

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Benzofurans and benzothiophenes are important pharmaceutical motifs, appearing in a broad range of small molecule therapeutic classes. Often overlooked by synthetic methodologists in favour reactions of the analogous indole bicyclic system, there is nevertheless a plurality of approaches to effecting benzofuran and benzothiophene C−H functionalisations. In this review, we summarise progress in this area over the past five years, including 1) alkylations, 2) arylations and heteroarylations, 3) carboxylations, carbamoylations, and C‐heteroatom bond formations and 4) cyclisations.

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Facile access to benzofuran derivatives through radical reactions with heteroatom-centered super-electron-donors

Jiang,

Wang,

Mou

et al. 2023

Nat Commun

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The development of suitable electron donors is critical to single-electron-transfer (SET) processes. The use of heteroatom-centered anions as super-electron-donors (SEDs) for direct SET reactions has rarely been studied. Here we show that heteroatom anions can be applied as SEDs to initiate radical reactions for facile synthesis of 3-substituted benzofurans. Phosphines, thiols and anilines bearing different substitution patterns work well in this inter-molecular radical coupling reaction and the 3-functionalized benzofuran products bearing heteroatomic functionalities are given in moderate to excellent yields. The reaction mechanism is elucidated via control experiments and computational methods. The afforded products show promising applications in both organic synthesis and pesticide development.

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Amiodarone-Induced Thyroid Dysfunction

Cited by 5 publications

References 100 publications

Thyroid scintigraphy in diagnosis of nodular and diffuse thyroid pathology

Thyroid scintigraphy in diagnosis of nodular and diffuse thyroid pathology

Recent Developments in C−H Functionalisation of Benzofurans and Benzothiophenes

Facile access to benzofuran derivatives through radical reactions with heteroatom-centered super-electron-donors

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