Amiodarone, lidocaine, magnesium or placebo in shock refractory ventricular arrhythmia: A Bayesian network meta-analysis

Khan, Safi U.; Winnicka, Lydia; Saleem, Muhammad A.; Rahman, Hammad; Rehman, Najeeb Ur

doi:10.1016/j.hrtlng.2017.09.001

Cited by 25 publications

(27 citation statements)

References 28 publications

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“…The utility of the BN methodology was only recognized within the past 25 years, with the more recent application of BN-based decision support being published in a variety of medical disciplines. (16–19) We have previously published Bayesian derived algorithms in predicting clinical outcomes post-LVAD including short term mortality, right ventricular failure and other adverse events. (10, 11) They have been shown to have superior predictive performance over traditional statistical methods.…”

Section: Discussionmentioning

confidence: 99%

A Bayesian Model to Predict Survival After Left Ventricular Assist Device Implantation

Kanwar

Lohmueller

Kormos

et al. 2018

JACC: Heart Failure

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Section: Discussionmentioning

confidence: 99%

A Bayesian Model to Predict Survival After Left Ventricular Assist Device Implantation

Kanwar

Lohmueller

Kormos

et al. 2018

JACC: Heart Failure

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“…In recent years, network meta-analysis has been developed. Compared with traditional meta-analysis, it can combine data related to multiple interventions, compare different managements according to indirect information, and generate a ranking for different interventions based on the efficacy [20]. Therefore, we performed a network meta-analysis to evaluate the comparative effectiveness and safety of Tuina, traction, acupuncture, and Chinese herbs, to help physicians better make treatment strategies for patients with LDH.…”

Section: Introductionmentioning

confidence: 99%

Comparisons of the Effectiveness and Safety of Tuina, Acupuncture, Traction, and Chinese Herbs for Lumbar Disc Herniation: A Systematic Review and Network Meta-Analysis

Zhang

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Background. Tuina, acupuncture, traction, and Chinese herbs play an important role in the treatment of lumbar disc herniation. However, the comparative effectiveness and safety of the four commonly utilized treatment modalities are still unclear. Objective. To compare the effectiveness and safety of the four interventions for lumbar disc herniation. Methods. Randomized controlled trials comparing any two of the four interventions in the treatment of lumbar disc herniation were identified using the following databases: PubMed, the Cochrane Library, Embase, Web of Science, the China National Knowledge Infrastructure, Chinese Science and Technology Periodical Database, and Wanfang data, and network meta-analysis was performed using STATA 14.0. Results. One hundred and twenty-one studies involving a total of 13075 patients were included. In all the outcome measurements, traction demonstrated a worst effectiveness, and Tuina and acupuncture demonstrated a best effectiveness, but no significant differences were found between Tuina and acupuncture. Compared with Tuina or acupuncture, Chinese herbs showed a similar effectiveness in Visual Analogue Score and Japanese Orthopedic Association Scores, but an inferior effectiveness in invalid rate and cure rate. Conclusions. In the treatment of lumbar disc herniation, Tuina and acupuncture were superior to traction or Chinese herbs, and the effectiveness of traction was the worst. However, considering the limitations of this review, more high-quality trials, especially those comparing Chinese herbs with the other three interventions, should be carried out in the future to further confirm the current findings.

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“…The major adverse events (AEs) are recurrence of arrhythmias and exacerbation of heart failure (Uchida et al, 2014 ). These adverse effects limit its widespread and long-term usage for all arrhythmia patients (Singh et al, 1995 ; Khan et al, 2017 ). Though there are some other approaches for VA such as pacemaker, cardiac resynchronization, anti-arrhythmic agents are still the mainstay therapy (Sardu et al, 2017b ).…”

Section: Introductionmentioning

confidence: 99%

Clinical Safety and Efficacy of Wenxin Keli-Amiodarone Combination on Heart Failure Complicated by Ventricular Arrhythmia: A Systematic Review and Meta-analysis

et al. 2018

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Objectives: To evaluate possible adverse effects and efficacy of Wenxin keli (WXKL)-amiodarone combination on heart failure complicated by ventricular arrhythmia.Methods: Nine electronic literature databases (the Cochrane Library, PubMed, EMBASE, IPA, AMED, CBM, CNKI, VIP, and WanFang) were searched up to February 2018. Two authors extracted data and assessed risk of bias of the included studies independently. Randomized controlled trials (RCTs) and quasi-RCTs about WXKL-amiodarone combination and amiodarone alone were eligible for comparison.Results: Thirteen trials involving 1,126 patients were included. Risk of bias was assessed as high in three studies and unclear in the remaining 10 studies. Six trials reported adverse events (AE). There was no obvious difference between WXKL-amiodarone combination group and amiodarone group in reported AEs (OR 0.64; 95%CI 0.39–1.07). The total effective rate of WXKL-amiodarone combination group was greater than that of amiodarone group (RR 1.22; 95%CI 1.16–1.29). The pooled results showed that the combination group was more effective in reducing heart rate (MD −2.25; 95%CI −2.61 to −1.88, P = 0.46, I2 = 0%), the frequency of ventricular premature complexes (MD −2.03; 95%CI −2.41 to −1.65) and QT dispersion (MD 5.59; 95%CI 3.60–7.58).Conclusion: The WXKL-amiodarone combination is safe and shows more protective effects on heart failure combined with ventricular arrhythmia compared with amiodarone alone. Further research is warranted, ideally involving large, prospective, rigorous trials, in order to confirm these findings.

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Amiodarone, lidocaine, magnesium or placebo in shock refractory ventricular arrhythmia: A Bayesian network meta-analysis

Cited by 25 publications

References 28 publications

A Bayesian Model to Predict Survival After Left Ventricular Assist Device Implantation

A Bayesian Model to Predict Survival After Left Ventricular Assist Device Implantation

Comparisons of the Effectiveness and Safety of Tuina, Acupuncture, Traction, and Chinese Herbs for Lumbar Disc Herniation: A Systematic Review and Network Meta-Analysis

Clinical Safety and Efficacy of Wenxin Keli-Amiodarone Combination on Heart Failure Complicated by Ventricular Arrhythmia: A Systematic Review and Meta-analysis

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