“…In one Amish sub-faction, the average relatedness of married couples is a little closer than second cousins, which is actually more distant than had all members been randomly paired (Hurd 1985); in a large Pennsylvania settlement, the inbreeding level nearly equates to second cousins (Dorsten, Hotchkiss, and King 1999;Khoury, et al 1987a). Further, because Amish rarely marry across sub-affiliation lines (Hurd 1997) or across settlements, and because they usually stay in the community in which they were born (Cross and McKusick 1970;Donnermeyer and Cooksey 2004), inbreeding is intensified, each major settlement representing a genetic sub-isolate (Cross 1976). High levels of relatedness are positively associated with farming as an occupation, younger age at marriage, higher number of siblings, and having a common last name (Khoury, Cohen, et al 1987a).…”