Amitriptyline and ethanol: Pharmacokinetic and pharmacodynamic interaction

Dorian, Paul; Sellers, Edward M.; Reed, Kenneth L.; Warsh, Jerry J.; Hamilton, Carolyn; Kaplan, Howard L.; Fan, Theresa

doi:10.1007/bf01037943

Cited by 66 publications

(26 citation statements)

References 18 publications

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“…Recently, Dorian et al (1983) demonstrated a large increment in plasma amitriptyline concentrations during administration of ethanol. Their design was to administer 25 mg of amitriptyline during continuous drinking.…”

Section: Discussionmentioning

confidence: 99%

Effects of antidepressants on skilled performance.

Linnoila¹,

Johnson²,

Dubyoski³

et al. 1984

Brit J Clinical Pharma

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Section: Discussionmentioning

confidence: 99%

Effects of antidepressants on skilled performance.

Linnoila¹,

Johnson²,

Dubyoski³

et al. 1984

Brit J Clinical Pharma

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“…The scientific literature also contains many recent studies that claim to have demonstrated interactions between chemicals, some examples of which include: (Abdelghani et al 1997;Abou-Donia et al 1985;Arnold et al 1996aArnold et al , 1996bArnold et al , 1997aBanks and Soliman 1997;Baynes et al 1997;Ben-Shlomo et al 1993;Bianchi et al 1994;Bianchi-Santamaria et al 1997;Bouakka et al 1988;Brown 1997;Christ et al1990;Cohen et al 1972;Cohen and Murphy 1971;Dent and Orrock 1997;Dorian et al 1983;Fletcher et al 1995;Garfield and Bukusoglu 1996;Groten et al 1996;Holzmann et al 1992;Howe et al 1998;Hu et al 1987;Jaworska et al 1997;Kissin et al 1990Kissin et al , 1992Kissin et al 1987;Kissin et al 1989Kissin et al , 1991Kreitzer and Spann 1973;Lau and Wang 1996;Le et al 1997;Levasseur et al 1997;Livingston and Dethlefsen 1979;Lu et al 1997;Marinovich et al 1994;Marinovich et al, 1996;Martin et al 1997;Mayer and Doolittle 1995;McCain et al 1997;McLac...…”

Section: Evaluative Criteria For Interaction Studiesmentioning

confidence: 99%

Evaluating Chemical Interaction Studies for Mixture Risk Assessment

Borgert

Price

Wells

et al. 2001

Human and Ecological Risk Assessment: An International Journal

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We describe a set of criteria to evaluate the quality of data and interpretations in chemical interaction studies. These criteria reflect the consensus of the literature on interaction analysis developed over decades of research in pharmacology, toxicology, and biometry; address common pitfalls in published interaction studies; and can be easily applied to common methods of interaction analysis. The criteria apply broadly to interaction data for drugs, pesticides, industrial chemicals, food additives, and natural products and are intended to assist risk assessors who must evaluate interaction studies for use in component-based mixture risk assessments. The criteria may also assist researchers interested in conducting interaction studies to inform mixture risk assessment. The criteria are also intended to serve larger scientific goals, including increasing the repeatability of results obtained in chemical interaction studies, enhancing the reliability of conclusions drawn from interaction data, providing greater consistency of interpretations among various analysts, and decreasing uncertainty in using interaction data in risk assessments. We describe the basis for each criterion and demonstrate their utility by using them to evaluate interaction studies from the recent toxicological and pharmacological literature, which serve as examples of different types of data sets that the risk assessor may encounter.

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“…Considering the bioavailability of amitriptyline [32,33], and the fluid intake of the mice (4 ml/ day), the estimated dosage was 40 mg/kg/day.…”

Section: Cells Animals and Solutionsmentioning

confidence: 99%

Influence of Amitriptyline on Eryptosis, Parasitemia and Survival of <i>Plasmodium Berghei</i>-Infected Mice

Brand

Koka

Lang

et al. 2008

Cell Physiol Biochem

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Plasmodia express a sphingomyelinase, which is apparently required for their development. On the other hand, the sphingomyelinase product ceramide has previously been shown to delay parasite development. Moreover, ceramide triggers suicidal erythrocyte death or eryptosis, characterized by exposure of phosphatidylserine at the erythrocyte surface and cell shrinkage. Accelerated eryptosis of infected erythrocytes is considered to clear infected erythrocytes from circulating blood and, thus, to favourably influence the clinical course of malaria. The present experiments explored whether the sphingomyelinase inhibitor amitriptyline or genetic knockout of host acid sphingomyelinase influence in vitro parasite growth, eryptosis of Plasmodium falciparum-infected human erythrocytes, in vivo parasitemia and survival of P. berghei-infected mice. Phosphatidylserine exposure was determined by annexin V-binding and cell volume by forward scatter in FACS analysis. In vitro infection of human erythrocytes increased annexin- binding, an effect blunted in the presence of amitriptyline (≥50 μM). Amitriptyline did not significantly alter intraerythrocytic parasite development but significantly (≥ 1 μM) delayed the increase in parasitemia in vitro. Most importantly, amitriptyline treatment (1 mM in drinking water) resulted in a significant delay of parasitemia and death of infected mice. However, upon infection, ceramide formation was stimulated in both, acid sphingomyelinase knockout mice (Smpd1^-/-) and their wild type littermates (Smpd1^+/+). Parasitemia following P. berghei infection was significantly lower in Smpd1^-/- than in Smpd1^+/+ mice but did not significantly extend the life span of infected animals. In conclusion, mammalian and parasite sphingomyelinase contribute to ceramide formation during malaria, whereby the parasite sphingomyelinase ultimately determines the course of the infection. Amitriptyline presumably blocks both sphingomyelinases and, thus, its use might be a novel strategy to treat malaria.

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Amitriptyline and ethanol: Pharmacokinetic and pharmacodynamic interaction

Cited by 66 publications

References 18 publications

Effects of antidepressants on skilled performance.

Effects of antidepressants on skilled performance.

Evaluating Chemical Interaction Studies for Mixture Risk Assessment

Influence of Amitriptyline on Eryptosis, Parasitemia and Survival of <i>Plasmodium Berghei</i>-Infected Mice

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