Amitriptyline in combination with repeated late sleep deprivation versus amitriptyline alone in major depression. A randomised study

Kuhs, H.; Farber, D. B.; Borgstädt, S.; Mrosek, S.; Tölle, Rainer

doi:10.1016/0165-0327(95)00074-7

Cited by 59 publications

(24 citation statements)

References 17 publications

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“…partial SD repeated once a week for 3 weeks [53] , or 3 times a week [54] , or twice a week for 2 weeks [55] , or 3 times a week for 2 weeks [56] , or 5 times at 5-day intervals [57] , or 6 times at 4-to 5-day intervals [58] ; or total SD twice a week [59] , or twice a week for 3 weeks [60,61] or for a month [62] , or twice a week followed by partial SD twice [63] , and so on. Repeated total SD once a week has also been proposed as a prophylactic treatment, to sustain response and prevent relapses [64,65] .…”

Section: Repetiton Of Treatmentmentioning

confidence: 99%

“…Total or partial, single or repeated antidepressant SD has been successfully associated with the selective serotonin reuptake inhibitors fluoxetine [45] , paroxetine [29,69,70] and sertraline [71,72], the dopaminergic amineptine [49], the mixed serotonergic-noradrenergic tricyclic antidepressants amitriptyline [58,66] and clomipramine [73][74][75][76][77] and the noradrenergic tricyclic nortriptyline [78] . The effect is synergistic: SD hastens the antidepressant action of drugs or, conversely, drugs sustain the transient antidepressant effects of SD over time.…”

Section: Interactions With Other Treatments: the Need For Combined Anmentioning

confidence: 99%

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Sleep Deprivation in Mood Disorders

2011

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Growing clinical evidence in support of the efficacy and safety of sleep deprivation (SD), and its biological mechanisms of action suggest that this technique can now be included among the first-line antidepressant treatment strategies for mood disorders. SD targets the broadly defined depressive syndrome, and can be administered according to several different treatment schedules: total versus partial, single versus repeated, alone or combined with antidepressant drugs, mood stabilizers, or other chronotherapeutic techniques, such as light therapy and sleep phase advance. The present review focuses on clinical evidence about the place of SD in therapy, its indications, dosage and timing of the therapeutic wake, interactions with other treatments, precautions and contraindications, adverse reactions, mechanism of action, and comparative efficacy, with the aim of providing the clinical psychiatrist with an updated, concise guide to its application.

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Section: Repetiton Of Treatmentmentioning

confidence: 99%

Section: Interactions With Other Treatments: the Need For Combined Anmentioning

confidence: 99%

Sleep Deprivation in Mood Disorders

2011

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“…Both total sleep deprivation and partial sleep deprivation therapies have beneficial effects on depression (112). Combination of medications and sleep deprivation therapy was found more effective than either alone (113)(114)(115). Sleep deprivation therapy can be used to improve depression during the period required for antidepressant medication to become fully effective.…”

Section: Depression and Quality Of Lifementioning

confidence: 99%

Sleep and Quality of Life in Depression

Çalıyurt¹

Sleep and Quality of Life in Clinical Medicine

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Summary Major depression is a common disorder; nearly 10% of the population suffers from a depressive illness in any given year. There is a strong association between sleep disturbances and depression. The most common sleep disturbance associated with major depressive disorder is insomnia. The relationship between insomnia and depression is bidirectional in that insomnia is one of the symptoms of depression and chronic insomnia can be a risk factor for depression. Depression causes changes in sleep patterns and sleep quality. Depressed patients showed prolonged sleep latency, increased wakefulness during sleep, early morning awakening, decreased sleep efficiency, decreased amounts of slow wave sleep and rapid eye movement (REM) sleep abnormalities. Depression is currently one of the leading causes of disability in the world. There is a direct association between the severity of depression and the level of disability. Depression has a big impact on quality of life of patients. Studies have showed that patients with major depressive disorder have poorer quality of life than persons from the general population. Effects of depression on quality of life are equal to or greater than those of patients with chronic medical conditions. Untreated depression usually does not go away by itself and often gets worse with time and increases a person's risk of suicide; it is a fact that up to 15% of those who are clinically depressed die through suicide. Clinical depression is treatable with counseling and medication. The majority of people with depressive disorders improve when they receive appropriate treatment. Improvement in depressive symptoms during the treatment is related to improvement in the quality of life. Antidepressants are shown to improve quality of life. There are some tools for evaluating quality of life in depressive patients, today. These tools help us to assess improvement in depressive patients beyond the extent to which depression rating scales do. In clinical settings, quality of life instruments can show us when patients begin to feel benefits of antidepressant therapy.

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“…A privação de sono exclusivamente, de preferência a PS total, pode ser usada para tratar um paciente deprimido não medicado ou ser iniciada ao mesmo tempo que a medicação antidepressiva com o objetivo de acelerar a resposta à medicação. Também pode ser acrescentada como estratégia para potencializar uma terapia em andamento com antidepressivo (Van den Hoofdakker et al, 1994;Kuhs et al, 1996). A resposta à PS é mais pronunciada nos pacientes que manifestam variação do humor durante o dia e de dia para dia (Wirz-Justice e Van den Hoofdakker, 1999).…”

Section: Privação De Sonounclassified