Amitriptyline-induced supersensitivity of a central muscarinic mechanism: Lithium blocks Amitriptyline- induced supersensitivity

Dilsaver, Steven C.; Hariharan, M.

doi:10.1016/0165-1781(88)90049-2

Cited by 5 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, similar to the case for dopaminergic and β-adrenergic receptors, it has been suggested that lithium can block the development of cholinergic receptor supersensitivity. In behavioral studies, chronic lithium is reported to enhance some cholinergically mediated responses, including catalepsy and hypothermia (105,110)). Perhaps the most striking example of lithium's ability to potentiate muscarinic responses comes from the lithium-pilocarpine seizure model (111–113).…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Molecular targets of lithium action

Corbella

Vieta

2003

Acta Neuropsychiatr.

View full text Add to dashboard Cite

Lithium is an effective drug for both the treatment and prophylaxis of bipolar disorder. However, the precise mechanism of lithium action is not yet well understood. Extensive research aiming to elucidate the molecular mechanisms underlying the therapeutic effects of lithium has revealed several possible targets. The behavioral and physiological manifestations of the illness are complex and are mediated by a network of interconnected neurotransmitter pathways. Thus, lithium's ability to modulate the release of serotonin at presynaptic sites and modulate receptor-mediated supersensitivity in the brain remains a relevant line of investigation. However, it is at the molecular level that some of the most exciting advances in the understanding of the long-term therapeutic action of lithium will continue in the coming years. The lithium cation possesses the selective ability, at clinically relevant concentrations, to alter the PI second-messenger system, potentially altering the activity and dynamic regulation of receptors that are coupled to this intracellular response. Subtypes of muscarinic receptors in the limbic system may represent particularly sensitive targets in this regard. Likewise, preclinical data have shown that lithium regulates arachidonic acid and the protein kinase C signaling cascades. It also indirectly regulates a number of factors involved in cell survival pathways, including cAMP response element binding protein, brain-derived neurotrophic factor, bcl-2 and mitogen-activated protein kinases, and may thus bring about delayed long-term beneficial effects via under-appreciated neurotrophic effects. Identification of the molecular targets for lithium in the brain could lead to the elucidation of the pathophysiology of bipolar disorder and the discovery of a new generation of mood stabilizers, which in turn may lead to improvements in the long-term outcome of this devastating illness (1).

show abstract

Section: Mechanism Of Actionmentioning

confidence: 99%

Molecular targets of lithium action

Corbella

Vieta

2003

Acta Neuropsychiatr.

View full text Add to dashboard Cite

show abstract

Neurobiologic effects of bright artificial light

Dilsaver

1989

Brain Research Reviews

View full text Add to dashboard Cite

Phenelzine produces subsensitivity to nicotine

Dilsaver¹,

Hariharan²,

Davidson³

1993

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Self Cite

View full text Add to dashboard Cite

1. The authors attempted to detect a possible effect of treatment with phenelzine on a physiological response to nicotine in the rat. 2. Positive findings in an animal model suggest the feasibility of more complicated experiments in animals and the possibility of studies involving human subjects. 3. Treatment of Sprague Dawley rats (n = 10) with phenelzine sulfate (15.0 mg/kg ip) every 48 hours for 14 days was associated with a 73.3% decrease in the hypothermic response to nicotine. 4. Treatment with phenelzine did not enhance the rate of elimination of nicotine. 5. The authors discuss a possible relationship between changes in nicotinic mechanisms and the therapeutic actions of drugs used to treat affective illness.

show abstract

Amitriptyline-induced supersensitivity of a central muscarinic mechanism: Lithium blocks Amitriptyline- induced supersensitivity

Cited by 5 publications

References 18 publications

Molecular targets of lithium action

Molecular targets of lithium action

Neurobiologic effects of bright artificial light

Phenelzine produces subsensitivity to nicotine

Contact Info

Product

Resources

About