AML-335: Treating Hematologic Oncology Patients in the Developing World During the COVID-19 Pandemic

Hambardzumyan, Liana; Badikyan, Maria; Grigoryan, Hayk; Tadevosyan, Artashes; Grigoryan, Tatevik; Martirosyan, Nare; Saaryan, Miranush; Farmazyan, Armine; Hakobyan, Yervand; Maes, Karen; Danielyan, Samvel; Tamamyan, Gevorg

doi:10.1016/s2152-2650(20)30759-x

Cited by 3 publications

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“…Case series and surveys conducted in Mexico and Armenia, respectively, noted that the main challenges during the COVID-19 pandemic were staff shortages (reduced to 50% in a single center in Mexico City) due to positive cases and direct contact with infected staff ( 62 , 63 ). At one hematology center in Armenia, researchers noted supply chain disruptions and delays (e.g., chemotherapy infusions postponed) as well as increases in the price of certain drugs and supplies (e.g., the price of PPE increased by more than 10 times) ( 62 ).…”

Section: Resultsmentioning

confidence: 99%

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The Global Impact of COVID-19 on Childhood Cancer Outcomes and Care Delivery - A Systematic Review

et al. 2022

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BackgroundChildhood cancer represents a leading cause of death and disease burden in high income countries (HICs) and low-and-middle income countries (LMICs). It is postulated that the current COVID-19 pandemic has hampered global development of pediatric oncology care programs. This systematic review aimed to comprehensively review the global impact of COVID-19 on childhood cancer clinical outcomes and care delivery.MethodsA systematic search was conducted on PubMed, Embase, Medline, and the African Medical Index from inception to November 3, 2021 following PRISMA guidelines. A manual search was performed to identify additional relevant studies. Articles were selected based on predetermined eligibility criteria.FindingsThe majority of studies reported patients with cancer and COVID-19 presenting as asymptomatic (HICs: 33.7%, LMICs: 22.0%) or with primary manifestations of fever (HICs: 36.1%, LMICs: 51.4%) and respiratory symptoms (HICs: 29.6%, LMICs: 11.7%). LMICs also reported a high frequency of patients presenting with cough (23.6%) and gastrointestinal symptoms (10.6%). The majority of patients were generally noted to have a good prognosis; however the crude mortality rate was higher in LMICs when compared to HICs (8.0% vs 1.8%). Moreover, the pandemic has resulted in delays and interruptions to cancer therapies and delays in childhood cancer diagnoses in both HICs and LMICs. However, these findings were disproportionately reported in LMICs, with significant staff shortages, supply chain disruptions, and limited access to cancer therapies for patients.ConclusionsThe COVID-19 pandemic has resulted in delays and interruptions to childhood cancer therapies and delays in childhood cancer diagnoses, and disproportionately so within LMICs. This review provides lessons learned for future system-wide disruptions to care, as well as provides key points for moving forward better with care through the remainder of this pandemic.Systematic Review RegistrationCRD42021266758, https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=266758

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Section: Resultsmentioning

confidence: 99%

“…Healthcare delays and disruptions have been particularly increased for pediatric oncology patients in LMICs. Staff shortages were described primarily in LMICs, with supply chain disruptions, and increase in prices of chemotherapeutic drugs and PPE ( 62 ). These results are well captured by Graetz et al.…”

Section: Discussionmentioning

confidence: 99%

The Global Impact of COVID-19 on Childhood Cancer Outcomes and Care Delivery - A Systematic Review

et al. 2022

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The Global Impact of COVID-19 on Childhood Cancer Outcomes and Care Delivery - A Systematic Review

Majeed¹,

Wright²,

Guo³

et al. 2022

SSRN Journal

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COVID-19 coronavirus infection in children: Clinical presentation, diagnosis, vaccination, and treatment

Rykov

Долгополов

2023

Ross. vestn. perinatol. pediatr.

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In late 2019, a new subtype of coronavirus named Severe Acute Respiratory Syndrome Coronavirus 2 (COVID-19 SARS-CoV-2) rapidly spread around the world, causing a global pandemic. Initially, the proportion of confirmed cases among children was relatively small, and it was believed that children were rarely infected. Subsequent observations have shown that in children and adolescents, the infection is either asymptomatic or paucisymptomatic, and therefore the true incidence is underestimated due to the lack of testing. The article systematizes the results of studies on the prevalence, diagnosis, clinical features, vaccination, and treatment of children with a new coronavirus infection COVID-19 SARS-CoV-2. The SARS-CoV-2 positivity rate throughout the peak of the pandemic in children was low compared to adults. Children are not only less likely to become infected with the virus, but they also endure the infection more easily than adults. The mortality rate in children with COVID-19 was <0.5%. In most children, infection is either asymptomatic or paucisymptomatic. Vaccination of children and adolescents is recommended mainly to achieve herd immunity in all age groups. However, there are no convincing data on the duration of the immune response, the level of the required protective antibody titer, as well as on the long-term side effects of vaccination due to the insufficient follow-up period and the uncertainty of the immune response criteria. As information is accumulated on the viral load of children and adolescents, their role in the transmission of the virus, diagnostic approaches in this age group are optimized. The effectiveness of the treatment was tested on patients admitted to the hospital, and recommendations for treatment were developed. Currently, global research efforts are focused on the protection of particularly vulnerable children, the prospects for total childhood vaccination, its effectiveness and safety.

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AML-335: Treating Hematologic Oncology Patients in the Developing World During the COVID-19 Pandemic

Cited by 3 publications

References 0 publications

The Global Impact of COVID-19 on Childhood Cancer Outcomes and Care Delivery - A Systematic Review

The Global Impact of COVID-19 on Childhood Cancer Outcomes and Care Delivery - A Systematic Review

The Global Impact of COVID-19 on Childhood Cancer Outcomes and Care Delivery - A Systematic Review

COVID-19 coronavirus infection in children: Clinical presentation, diagnosis, vaccination, and treatment

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