AML in Saudi Arabia: Analysis According to the European LeukaemiaNet 2017 Cytogenetic Classification

Alabdulwahab, Amal; Elsayed, Hussein; Sherisher, Mohamed A.; Zeeneldin, Ahmed A.; Elbjeirami, Wafa M.

doi:10.1016/j.clml.2019.12.005

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…For contrast, in the USA, analysis of Surveillance, Epidemiology, and End Results (SEER) data of AML from 2011 to 2016 showed a median age at AML diagnosis of 68 years [6,13], and in the UK, the reported median age at diagnosis was 63 years [14]. Interestingly, a recent study of the Western Region of Saudi Arabia reported a median age at diagnosis of 42 years, which was even lower than our cohort [15].…”

Section: Discussioncontrasting

confidence: 93%

“…We also found that patients with AML over the age of 55 years had shorter OS compared to younger patients. Patients in the ELN intermediate and adverse risk categories showed progressively worse OS compared to the favorable risk group, a finding which is comparable to other published studies [15].…”

Section: Discussionsupporting

confidence: 89%

“…Based on SEER data analysis, males are 1.6 times more likely to be diagnosed with AML than females, with an age-adjusted incidence of 5.42 and 3.47 per 100,000 person-years in males and females, respectively [ 6 , 14 ]. Studies from Saudi Arabia also reported higher frequencies of cases among males than females [ 15 ]. These observations indicate that as the population ages, the incidence of AML will also increase; accordingly, associated health care requirements and costs will change with time [ 9 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

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Epidemiology of de novo Acute Myeloid Leukemia in Kuwait per the 2016 WHO Classification

et al. 2022

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Introduction: Acute myeloid leukemia (AML) is a hematological malignancy that arises from the clonal proliferation of immature myeloid cells. Although the number of AML cases has dramatically increased worldwide, an understanding of its prevalence and incidence in Kuwait is lacking. Method: This study reports the incidence of AML and patient demographics in the country from 2014 to 2020, according to the 2016 WHO classification of AML. Data on patients with AML, including acute promyelocytic leukemia (APL), were collected from a clinical validation cohort with 281 cases analyzed in this study. Results: The overall median age of the population was 47 years with a 1.1:1 male-to-female ratio. Over the study period, the incidence of AML demonstrated a general increasing trend, with the highest and lowest overall incidence occurring in 2018 and 2015, respectively. The frequency of APL in our cohort was 8.9%. Regarding the 2017 ELN risk stratification of patients with AML, 37%, 46%, and 17% of patients had a favorable, intermediate, and adverse risk, respectively. After postinduction, 57% of cases achieved complete remission, and the median overall survival was 37 months. Conclusion: Our study may help predict the future trends of AML in the Middle East to ultimately improve clinical management and patient outcomes.

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Section: Discussioncontrasting

confidence: 93%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Epidemiology of de novo Acute Myeloid Leukemia in Kuwait per the 2016 WHO Classification

et al. 2022

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“… 12 , 13 In Saudi Arabia, the median age at diagnosis of AML appears to be lower than that reported for the United States and Europe, although the evidence base to support the assumption is limited to single institution experiences. 14 , 15 Although there is no published accurate estimate of AML ranking in comparison with other cancers, leukemia, in general, is a public health burden in Saudi Arabia and ranked as the fifth most prevalent type of cancer. 7 Over the past 15 years, the incidence of leukemia increased steadily in the different age groups.…”

Section: Epidemiology and Burden Of Aml In Saudi Arabiamentioning

confidence: 99%

Management Approach to Acute Myeloid Leukemia Leveraging the Available Resources in View of the Latest Evidence: Consensus of the Saudi Society of Blood and Marrow Transplantation

Alahmari

Alzahrani

Shehry

et al. 2021

JCO Global Oncology

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PURPOSE Acute myeloid leukemia (AML) is the most prevalent acute leukemia in adults and is responsible for the majority of cancer-related mortality. In Saudi Arabia, leukemia is ranked the fifth most prevalent type of malignancy in adults. Our aim is to review existing epidemiologic data in Saudi Arabia and develop consensus guidelines for management of AML. METHODS We review literature related to AML epidemiology, treatment patterns, and outcomes in Saudi Arabia, as well as literature related to the current advances in AML treatment. A panel of 10 experts from eight institutions in Saudi Arabia reviewed the literature and developed a consensus statement. RESULT We provide an update of the available AML epidemiologic data in Saudi Arabia and describe recent developments in the diagnostic workup, risk stratification, and treatment algorithm. The consensus recommendations for the management of AML in Saudi Arabia were developed. CONCLUSION The recommendations are in parallel with the recent international guidelines for the diagnosis and management of AML.

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Analysis of FLT3-Activating Mutations in Patients With Acute Myelogenous Leukemia in Jordan: Association With FAB Subtypes and Identification of Subgroups With Poor Prognosis

Halahleh

Taqash

Abdelkhaleq

et al. 2021

Clinical Lymphoma Myeloma and Leukemia

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AML in Saudi Arabia: Analysis According to the European LeukaemiaNet 2017 Cytogenetic Classification

Cited by 5 publications

References 18 publications

Epidemiology of de novo Acute Myeloid Leukemia in Kuwait per the 2016 WHO Classification

Epidemiology of de novo Acute Myeloid Leukemia in Kuwait per the 2016 WHO Classification

Management Approach to Acute Myeloid Leukemia Leveraging the Available Resources in View of the Latest Evidence: Consensus of the Saudi Society of Blood and Marrow Transplantation

Analysis of FLT3-Activating Mutations in Patients With Acute Myelogenous Leukemia in Jordan: Association With FAB Subtypes and Identification of Subgroups With Poor Prognosis

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