Amlodipine-Associated Photodistributed Telangiectasia

Photodistributed eruptive telangiectasias: an uncommon adverse drug reaction. A retrospective case series

“…Reports of iatrogenic telangiectasia are scarce, and only some of these cases were related to photoexposure 2 . Cases of PT have been described with calcium channel blockers (CCBs) such as nifedipine, amlodipine and felodipine, 3–7 cephalosporins such as cefotaxime, 8 selective serotonin reuptake inhibitors (SSRIs), such as escitalopram and venlafaxine 2, 9 and psychotropic drugs such as mirtazapine and levetiracetam 10 …”

“…In most cases, skin lesions arise 1 month to 1 year after drug commencement and disappear 1–2 months after drug withdrawal 5 . In the presence of telangiectasias, several differential diagnoses need to be considered, including liver diseases, hyperoestrogenism, telangiectasia macularis perstans and recurrent eruptive pseudoangiomatosis 2, 6 . The distribution of the lesions and the clinical history suggest a correlation between the telangiectasia onset photoexposure and drug intake.…”

Photodistributed telangiectasia following the use of psychotropic drugs

“…Photodistributed telangiectasias are commonly reported after systemic therapies with antibiotics, antidepressants, antiepileptics, antihypertensive or anti‐inflammatory drugs 6‐9 . In the literature, there are no reports of photodistributed telangiectasias secondary to intake of mirtazapine or levetiracetam, probably because of misdiagnosis due to poor knowledge of such reactions.…”