Amlodipine versus nifedipine in the treatment of mild-to-moderate hypertension in black Africans

Isah, Ambrose O.; Obasohan, A. O.; Oyewo, E. A.; Ohaju-Obodo, John

doi:10.1016/s0011-393x(96)80038-5

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…This was observed early following the introduction of the CCBs. [ 31 32 ] This finding need to be further investigated as it was also seen using the MedDRA[ 18 ] system organ classification that the renal and urinary disorders had the highest frequency. We equally note the development of dizziness and dryness of legs to alpha blockers, (though infrequently used in this study) two of the users (22%) had adverse reactions, the reactions observed may be related to the orthostatic hypotensive effect of alpha blockers.…”

Section: Discussionmentioning

confidence: 99%

A profile of adverse effects of antihypertensive medicines in a tertiary care clinic in Nigeria

Olowofela

Isah

2017

Ann Afr Med

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Background:There has been a dearth of comprehensive data on the profile of adverse reactions to antihypertensive medicines in the Nigerian setting despite increased use.Objective:This study was aimed to characterize the adverse reactions experienced in the homogenously black African population.Methods:The study was carried out at the University of Benin Teaching Hospital, Benin City, Nigeria, in consenting eligible hypertensive patients ≥18 years. Adverse reactions were sought using patient's self-report and a medicine-induced symptom checklist.Results:A total of 514 patients (340 females) aged 22–97 years were studied. Thirteen percent, 27.6%, 26.7%, 22.0%, and 10.7% were on 1, 2, 3, 4, and ≥5 medicines, respectively, for control of their blood pressure with the frequency of adverse effects increasing proportionately up to four medicines. Adverse reactions to antihypertensive medicines were reported by a total of 93 (18.1%) patients. Diuretics – 27.9%, calcium channel blockers (CCBs) – 26.8%, and angiotensin-converting enzyme inhibitors (ACEIs) – 26.8% accounted for most of the adverse reactions seen, notably frequent micturition and headaches (CCB); excessive micturition and dizziness (diuretics); dry irritating cough (ACEI). Notable complaints for all patients using the checklist were increased frequency of micturition, reduction in libido, and headaches. The reactions resulted in the discontinuation and substitution of therapy in 49.5% of the patients.Conclusions:The characterization of these reactions in Nigerians requires further studies as frequent micturition reported is still a neglected complaint in antihypertensive therapy.

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Section: Discussionmentioning

confidence: 99%

A profile of adverse effects of antihypertensive medicines in a tertiary care clinic in Nigeria

Olowofela

Isah

2017

Ann Afr Med

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“…Harvey et al noted in their review of SLE that low serum complement C4 is very infrequent in over the age forty years. 10 The patients presentation was thus atypical.…”

Section: Discussionmentioning

confidence: 99%

Atypical presentation of systemic lupus erythematosus in a west african male

Yeboah-Mensah¹

2014

Ghana Medical Journal

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“…Other comparative studies have shown calcium channel blockade to be more effective than ACE inhibition and β‐blockade in African‐Caribbean patients 3 , 36 , 37 . Amlodipine, a long‐acting calcium channel blocker, and nifedipine successfully normalised blood pressure (diastolic blood pressure <90 mmHg) in over 70% of African‐Caribbean patients after 12 weeks of treatment 41 . Amlodipine also reduced mean 24‐hour blood pressure in African‐Caribbean patients with severe hypertension from 181/119 mmHg at baseline to 140/92 mmHg after three months of treatment 42 .…”

Section: Antihypertensive Therapy and Metabolic Risk Factorsmentioning

confidence: 98%

Blood Pressure Control and Cardiovascular Risk in Patients of Indo‐asian and African‐caribbean Descent

Burden

1998

Int J Clinical Practice

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Hypertension is a major risk factor for premature death. Large outcome studies have demonstrated reduced morbidity and mortality associated with antihypertensive therapy in mixed patient populations, but data on morbidity and mortality in defined ethnic groups are lacking. Management of cardiovascular risk factors, which frequently coexist with hypertension, presents a logical management strategy in these patients. Indo-Asian patients are particularly prone to insulin resistance and non-insulin-dependent diabetes mellitus (NIDDM), which are associated in turn with potentially atherogenic lipid profiles and poor cardiovascular outcomes. Diuretics and B-adrenoceptor blockers exert theoretically adverse effects on lipid profiles and should be used with caution in Indo-Asian patients at risk of developing NIDDM. Hypertensive African-Caribbean patients are at increased risk of stroke and tend to suffer greater target organ damage, including renal dysfunction and cardiac hypertrophy. Hypertension in African-Caribbean patients is less sensitive to B-adrenoceptor blockade or ACE inhibition than in white patients. Selective u 1 -adrenoceptor antagonists and calcium channel blockers are equally effective antihypertensive agents in all races. While calcium channel blockers are metabolically neutral, u 1 -adrenoceptor blockers promote a potentially less atherogenic lipid profile. Further study of the effects of antihypertensive treatment on morbidity and mortality in ethnic groups is required, particularly in Indo-Asian patients.

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Amlodipine versus nifedipine in the treatment of mild-to-moderate hypertension in black Africans

Cited by 4 publications

References 11 publications

A profile of adverse effects of antihypertensive medicines in a tertiary care clinic in Nigeria

A profile of adverse effects of antihypertensive medicines in a tertiary care clinic in Nigeria

Atypical presentation of systemic lupus erythematosus in a west african male

Blood Pressure Control and Cardiovascular Risk in Patients of Indo‐asian and African‐caribbean Descent

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