Ammonium Glycyrrhizinate-Loaded Niosomes as a Potential Nanotherapeutic System for Anti-Inflammatory Activity in Murine Models [Retraction]

Marianecci, Carlotta; Rinaldi, Federica; Marzio, Luisa Di; Mastriota, Marica; Pieretti, Stefano; Celia, Christian; Paolino, Donatella; Iannone, Michelangelo; Fresta, Massimo; Carafa, Maria

doi:10.2147/ijn.s384533

Cited by 7 publications

(9 citation statements)

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“…In the presence of the AGA-CMC hydrogel extracts, the levels of TNF-α and IL-1β are significantly reduced (Figure H,I), which implies that the AGA-CMC hydrogel has an efficient anti-inflammation effect. Previous studies have shown that GA molecule and its derivatives can effectively diminish inflammation by inhibiting cytokine activities (e.g., HMGB1). ,, Therefore, we mainly attribute this strong anti-inflammatory effect of hydrogels to the inherent anti-inflammatory activity of AGA. To verify our speculation, the anti-inflammation properties of AGA solutions with different oxidation degrees were further evaluated at a nontoxic concentration.…”

Section: Resultsmentioning

confidence: 94%

“…As shown in Figure derivatives can effectively diminish inflammation by inhibiting cytokine activities (e.g., HMGB1). 41,59,60 Therefore, we mainly attribute this strong anti-inflammatory effect of hydrogels to the inherent anti-inflammatory activity of AGA. To verify our speculation, the anti-inflammation properties of AGA solutions with different oxidation degrees were further evaluated at a nontoxic concentration.…”

Section: In Vitro Biocompatibility and Anti-inflammation Effectsmentioning

confidence: 99%

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Injectable Self-Healing Adhesive Natural Glycyrrhizic Acid Bioactive Hydrogel for Bacteria-Infected Wound Healing

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

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Bioactive hydrogels self-assembled from naturally occurring herbal small molecules are attracting growing interest for applications in wound healing, due to their versatile intrinsic biological activities, excellent biocompatibility, as well as facile, sustainable, and eco-friendly processes. However, the development of supramolecular herb hydrogels with sufficient strength and multifunctionality as an ideal wound dressing in clinical practice remains a challenge. In this work, inspired by the efficient clinic therapy and directed self-assembly of natural saponin glycyrrhizic acid (GA), we create a novel GA-based hybrid hydrogel to promote full-thickness wound healing and bacterial-infected wound healing. This hydrogel possesses excellent stability and mechanical performance and multifunctional properties, including injectable, shape-adaptation and remodeling, self-healing, and adhesive abilities. This is attributed to the hierarchical dual-network that comprises the self-assembled hydrogen-bond fibrillar network of aldehyde-contained GA (AGA) and the dynamic covalent network through Schiff base reaction between AGA and a biopolymer carboxymethyl chitosan (CMC). Notably, benefiting from the inherent strong biological activity of GA, the AGA-CMC hybrid hydrogel exhibits unique and significant anti-inflammation effects and antibacterial ability, especially toward the Gram-positive Staphylococcus aureus (S. aureus). In vivo experiments demonstrate that the AGA-CMC hydrogel promotes uninfected skin wound healing and S. aureus-infected skin wound healing by enhancing the formation of granulation tissue, facilitating collagen deposition, reducing bacterial infection, and downregulating inflammatory response. This study highlights the design of new and multifunctional bioactive herb hydrogels from natural drug-food homologous small molecules, which can serve as a promising wound-healing dressing for biomedical applications.

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Section: Resultsmentioning

confidence: 94%

Section: In Vitro Biocompatibility and Anti-inflammation Effectsmentioning

confidence: 99%

Injectable Self-Healing Adhesive Natural Glycyrrhizic Acid Bioactive Hydrogel for Bacteria-Infected Wound Healing

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

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“…Ammonium glycyrrhizinate-loaded niosomes (AGN) have been explored as a potential nanotherapeutic system for anti-inflammatory activity in murine models [ 90 ]. The study demonstrated that neutral or pH-sensitive AGN are desirable nanotherapeutics for anti-inflammatory and antinociceptive therapy [ 90 ].…”

Section: Specialised Niosomesmentioning

confidence: 99%

Current Advances in Specialised Niosomal Drug Delivery: Manufacture, Characterization and Drug Delivery Applications

Witika

Bassey

Demana

et al. 2022

IJMS

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Development of nanomaterials for drug delivery has received considerable attention due to their potential for achieving on-target delivery to the diseased area while the surrounding healthy tissue is spared. Safe and efficiently delivered payloads have always been a challenge in pharmaceutics. Niosomes are self-assembled vesicular nanocarriers formed by hydration of a non-ionic surfactant, cholesterol or other molecules that combine to form a versatile drug delivery system with a variety of applications ranging from topical delivery to targeted delivery. Niosomes have advantages similar to those of liposomes with regards to their ability to incorporate both hydrophilic and hydrophobic payloads. Moreover, niosomes have simple manufacturing methods, low production cost and exhibit extended stability, consequently overcoming the major drawbacks associated with liposomes. This review provides a comprehensive summary of niosomal research to date, including the types of niosomes and critical material attributes (CMA) and critical process parameters (CPP) of niosomes and their effects on the critical quality attributes (CQA) of the technology. Furthermore, physical characterisation techniques of niosomes are provided. The review then highlights recent applications of specialised niosomes in drug delivery. Finally, limitations and prospects for this technology are discussed.

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“…The antipsoriatic studies performed on mice tail models showed significantly higher efficacy of TAM-FMV gel and TAM-PLO compare to the conventional TAM-hydrogel [ 112 ]. Ammonium glycyrrhizinate niosomes as a potential nano-vesicular system for psoriasis treatment employing murine models was proposed by Marianecci et al [ 113 ]. Their results suggested that drug-loaded niosomes shows reduced edema and nociception in comparison to placebo niosomes and drug alone [ 113 ].…”

Section: Nanoscale Topical Pharmacotherapy In Effective Treatment Of ...mentioning

confidence: 99%

“…Ammonium glycyrrhizinate niosomes as a potential nano-vesicular system for psoriasis treatment employing murine models was proposed by Marianecci et al [ 113 ]. Their results suggested that drug-loaded niosomes shows reduced edema and nociception in comparison to placebo niosomes and drug alone [ 113 ]. Meng et al developed a novel topical niosomes loaded with celastrol and, through an in vivo study, suggested its efficacy in alleviating psoriasis symptoms (erythema and scaling) in a mouse model of psoriasis [ 114 ].…”

Section: Nanoscale Topical Pharmacotherapy In Effective Treatment Of ...mentioning

confidence: 99%

Nanoscale Topical Pharmacotherapy in Management of Psoriasis: Contemporary Research and Scope

Ahmad

Mohammed

Algahtani

et al. 2022

JFB

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Psoriasis is a typical dermal condition that has been anticipated since prehistoric times when it was mistakenly implicit in being a variant of leprosy. It is an atypical organ-specific autoimmune disorder, which is triggered by the activation of T-cells and/or B-cells. Until now, the pathophysiology of this disease is not completely explicated and still, many research investigations are ongoing. Different approaches have been investigated to treat this dreadful skin disease using various anti-psoriatic drugs of different modes of action through smart drug-delivery systems. Nevertheless, there is no ideal therapy for a complete cure of psoriasis owing to the dearth of an ideal drug-delivery system for anti-psoriatic drugs. The conventional pharmacotherapy approaches for the treatment of psoriasis demand various classes of anti-psoriatic drugs with optimum benefit/risk ratio and insignificant untoward effects. The advancement in nanoscale drug delivery had a great impact on the establishment of a nanomedicine-based therapy for better management of psoriasis in recent times. Nanodrug carriers are exploited to design and develop nanomedicine-based therapy for psoriasis. It has a promising future in the improvement of the therapeutic efficacy of conventional anti-psoriatic drugs. The present manuscript aims to discuss the pathophysiology, conventional pharmacotherapy, and contemporary research in the area of nanoscale topical drug delivery systems for better management of psoriasis including the significance of targeted pharmacotherapy in psoriasis.

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Ammonium Glycyrrhizinate-Loaded Niosomes as a Potential Nanotherapeutic System for Anti-Inflammatory Activity in Murine Models [Retraction]

Cited by 7 publications

References 0 publications

Injectable Self-Healing Adhesive Natural Glycyrrhizic Acid Bioactive Hydrogel for Bacteria-Infected Wound Healing

Injectable Self-Healing Adhesive Natural Glycyrrhizic Acid Bioactive Hydrogel for Bacteria-Infected Wound Healing

Current Advances in Specialised Niosomal Drug Delivery: Manufacture, Characterization and Drug Delivery Applications

Nanoscale Topical Pharmacotherapy in Management of Psoriasis: Contemporary Research and Scope

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