Ammonium ions and glutamine inhibit sporulation of Coprinus cinereus basidia assayed in vitro

Chiu, Siu Wai; Moore, David

doi:10.1016/0309-1651(88)90038-0

Cited by 22 publications

(6 citation statements)

References 20 publications

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“…Conversely, Aspergillus conidiophores transferred to submerged culture will revert to vigorous hyphal growth. In the black ink mushroom Coprinopsis cinerea and S. cerevisiae, the addition of ammonium can revert a reproductive state to a vegetative one (Chiu and Moore 1988a). Because morphotype changes in fungi are often an environmentally controlled flexible process, continued development requires genetic reinforcement appropriate for the cellular microenvironment.…”

Section: Morphogenesis In the Fungal Life Cyclementioning

confidence: 99%

Fungal Morphogenesis

Lin

Alspaugh

Liu

et al. 2014

Cold Spring Harbor Perspectives in Medicine

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Morphogenesis in fungi is often induced by extracellular factors and executed by fungal genetic factors. Cell surface changes and alterations of the microenvironment often accompany morphogenetic changes in fungi. In this review, we will first discuss the general traits of yeast and hyphal morphotypes and how morphogenesis affects development and adaptation by fungi to their native niches, including host niches. Then we will focus on the molecular machinery responsible for the two most fundamental growth forms, yeast and hyphae. Last, we will describe how fungi incorporate exogenous environmental and host signals together with genetic factors to determine their morphotype and how morphogenesis, in turn, shapes the fungal microenvironment. PROPERTIES OF MORPHOGENESIS IN FUNGAL CELLS

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Section: Morphogenesis In the Fungal Life Cyclementioning

confidence: 99%

Fungal Morphogenesis

Lin

Alspaugh

Liu

et al. 2014

Cold Spring Harbor Perspectives in Medicine

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“…The urea concentration in cap cells therefore remains unchanged, and it is thought that this mechanism contributes to the inflation of hymenial cells (332). The cap always contains less free ammonium than does the stipe (123,332); this is especially important for meiosis and spore formation, which are inhibited by free ammonium and also by glutamine (87,89,346). It is possible that the NADP-dependent glutamate dehydrogenase and glutamine synthase act together as an ammonium-scavenging system to protect the meiotic apparatus from ammonium inhibition (119,123,331,333).…”

Section: Physiological Factorsmentioning

confidence: 99%

Life History and Developmental Processes in the BasidiomyceteCoprinus cinereus

Kües

2000

Microbiol Mol Biol Rev

435

336

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SUMMARY Coprinus cinereus has two main types of mycelia, the asexual monokaryon and the sexual dikaryon, formed by fusion of compatible monokaryons. Syngamy (plasmogamy) and karyogamy are spatially and temporally separated, which is typical for basidiomycetous fungi. This property of the dikaryon enables an easy exchange of nuclear partners in further dikaryotic-monokaryotic and dikaryotic-dikaryotic mycelial fusions. Fruiting bodies normally develop on the dikaryon, and the cytological process of fruiting-body development has been described in its principles. Within the specialized basidia, present within the gills of the fruiting bodies, karyogamy occurs in a synchronized manner. It is directly followed by meiosis and by the production of the meiotic basidiospores. The synchrony of karyogamy and meiosis has made the fungus a classical object to study meiotic cytology and recombination. Several genes involved in these processes have been identified. Both monokaryons and dikaryons can form multicellular resting bodies (sclerotia) and different types of mitotic spores, the small uninucleate aerial oidia, and, within submerged mycelium, the large thick-walled chlamydospores. The decision about whether a structure will be formed is made on the basis of environmental signals (light, temperature, humidity, and nutrients). Of the intrinsic factors that control development, the products of the two mating type loci are most important. Mutant complementation and PCR approaches identified further genes which possibly link the two mating-type pathways with each other and with nutritional regulation, for example with the cAMP signaling pathway. Among genes specifically expressed within the fruiting body are those for two galectins, β-galactoside binding lectins that probably act in hyphal aggregation. These genes serve as molecular markers to study development in wild-type and mutant strains. The isolation of genes for potential non-DNA methyltransferases, needed for tissue formation within the fruiting body, promises the discovery of new signaling pathways, possibly involving secondary fungal metabolites.

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“…The interpretation is, therefore, that NADP-GDH and GS activities are specifically enhanced in basidia of Coprinopsis cinerea to protect those cells from the inhibitory effects of ammonium ions, and meiosis and sporulation were indeed shown to be sensitive to inhibition by ammonium ions by direct experiments in vitro and in vivo (Fig. 7) (Bastouill-Descollonges & Manachère, 1984;Chiu & Moore, 1988a, 1988b, 1990c. Fig.…”

Section: Metabolic Regulation In Relation To Morphogenesismentioning

confidence: 95%

A 21st century miniguide to sporophore morphogenesis and development in Agaricomycetes and their biotechnological potential

Loftus¹,

Sánchez²,

Moore³

et al. 2020

Mexjbiotechnol

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We review the most recent developments in understanding the nature of development and morphogenesis in fungi and suggest how it might be applied to biotechnological manipulation of some cultivated mushrooms. We believe that it is essential to match the deductions of the molecular observations of the genomics generation with the inductive reasoning of the in vivo experiments and observations of the pregenomics generations to take full advantage of the synergism between the approaches to illuminate better the living biology of the system. As specific examples we show how model mushroom fungi (Coprinopsis and Volvariella) make hymenia and gills (not forgetting how the polypore Phellinus makes tubes), developmental commitment and pattern formation. The Coprinopsis sporophore also provides examples for the construction of mushroom stems and the coordination of cell behaviour throughout the maturing sporophore and the timing process that achieves that. This leads us to consider the mechanics of the mushroom and its dependence on the biochemistry and regulation of metabolism in relation to morphogenesis, and how it varies between species. We finish with our summary of the basic principles of fungal developmental biology. Having demonstrated how classic approaches allowed progress to be made in the study of fungal development we show how this has been accelerated by genomics and other aspects of global analysis of macromolecules. We also include work on some cultivated mushrooms to illustrate how the generalisations from research on model organisms might be applied in mushroom farming.

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Ammonium ions and glutamine inhibit sporulation of Coprinus cinereus basidia assayed in vitro

Cited by 22 publications

References 20 publications

Fungal Morphogenesis

Fungal Morphogenesis

Life History and Developmental Processes in the BasidiomyceteCoprinus cinereus

A 21st century miniguide to sporophore morphogenesis and development in Agaricomycetes and their biotechnological potential

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