AMMVF-DTI: A Novel Model Predicting Drug–Target Interactions Based on Attention Mechanism and Multi-View Fusion

Wang, Lu; Zhou, Yifeng; Chen, Qu

doi:10.3390/ijms241814142

Cited by 8 publications

(2 citation statements)

References 63 publications

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“…The drug and protein feature vectors were concatenated and fed into fully connected layers for final result prediction. A deep learning model called AMMVF-DTI was developed by Wang et al (2023) , which combined multimodal and multi-view information and incorporated attention mechanisms for feature fusion to enhance prediction accuracy and reliability.…”

Section: Introductionmentioning

confidence: 99%

MIFAM-DTI: a drug-target interactions predicting model based on multi-source information fusion and attention mechanism

Li,

Sun,

Liu

et al. 2024

Front. Genet.

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Accurate identification of potential drug-target pairs is a crucial step in drug development and drug repositioning, which is characterized by the ability of the drug to bind to and modulate the activity of the target molecule, resulting in the desired therapeutic effect. As machine learning and deep learning technologies advance, an increasing number of models are being engaged for the prediction of drug-target interactions. However, there is still a great challenge to improve the accuracy and efficiency of predicting. In this study, we proposed a deep learning method called Multi-source Information Fusion and Attention Mechanism for Drug-Target Interaction (MIFAM-DTI) to predict drug-target interactions. Firstly, the physicochemical property feature vector and the Molecular ACCess System molecular fingerprint feature vector of a drug were extracted based on its SMILES sequence. The dipeptide composition feature vector and the Evolutionary Scale Modeling -1b feature vector of a target were constructed based on its amino acid sequence information. Secondly, the PCA method was employed to reduce the dimensionality of the four feature vectors, and the adjacency matrices were constructed by calculating the cosine similarity. Thirdly, the two feature vectors of each drug were concatenated and the two adjacency matrices were subjected to a logical OR operation. And then they were fed into a model composed of graph attention network and multi-head self-attention to obtain the final drug feature vectors. With the same method, the final target feature vectors were obtained. Finally, these final feature vectors were concatenated, which served as the input to a fully connected layer, resulting in the prediction output. MIFAM-DTI not only integrated multi-source information to capture the drug and target features more comprehensively, but also utilized the graph attention network and multi-head self-attention to autonomously learn attention weights and more comprehensively capture information in sequence data. Experimental results demonstrated that MIFAM-DTI outperformed state-of-the-art methods in terms of AUC and AUPR. Case study results of coenzymes involved in cellular energy metabolism also demonstrated the effectiveness and practicality of MIFAM-DTI. The source code and experimental data for MIFAM-DTI are available at https://github.com/Search-AB/MIFAM-DTI.

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Section: Introductionmentioning

confidence: 99%

MIFAM-DTI: a drug-target interactions predicting model based on multi-source information fusion and attention mechanism

Li,

Sun,

Liu

et al. 2024

Front. Genet.

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“…The work of Lu Wang et al [19] focused on developing a method relatively similar to PASS in order to identify potential drug-target interactions (DTIs). The use of these computational methods can systematically assess and prioritize the most probable targets for a specific drug [20][21][22][23], facilitating more focused experimental validation and uncovering new therapeutic uses for existing drugs [24,25].…”

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confidence: 99%