Amnestic syndrome of the medial temporal type identifies prodromal AD

Sarazin, Marie; Berr, Claudine; Rotrou, J. de; Fabrigoule, Colette; Pasquier, Florence; Legrain, S.; Michel, Bernard; Puel, Michèle; Volteau, Magali; Touchon, Jacques; Verny, Marc; Dubois, Bruno

doi:10.1212/01.wnl.0000279336.36610.f7

Cited by 416 publications

(392 citation statements)

References 42 publications

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“…It is used in five major longitudinal aging studies besides the BLSA: (1) Einstein Aging Study (EAS; Grober et al, 1988); (2) Mayo Older Adults Normative Study (Petersen et al, 1995); (3) Berlin Aging Study (Lindenberger & Reischies, 1999); (4) Canadian Study of Health and Aging (Tuokko et al, 1995); and (5) Personnes Agees QUID (Sarazin et al, 2007). FCSR is also used in the Alzheimer's Disease Cooperative Study Instrumentation Protocol to identify persons with prevalent dementia and trigger clinical evaluations for incident dementia (Ferris et al, 2006).…”

Section: Fcsrtmentioning

confidence: 99%

Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease

Grober

Hall

Lipton

et al. 2008

J. Inter. Neuropsych. Soc.

353

314

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In the Baltimore Longitudinal Study of Aging (BLSA), we examined the temporal unfolding of declining performance on tests of episodic memory (Free Recall on the Free and Cued Selective Reminding Test), executive function (Category Fluency, Letter Fluency, and Trails), and Verbal Intelligence (Nelson, 1982; American Version of the Nelson Adult Reading Test [AMNART] ) before the diagnosis of dementia in 92 subjects with incident Alzheimer's disease (AD) followed for up to 15 years before diagnosis. To examine the preclinical onset of cognitive decline, we aligned subjects at the time of initial AD diagnosis and examined the cognitive course preceding diagnosis. We found that declines in performance on tests of episodic memory accelerated 7 years before diagnosis. Declining performance on tests of executive function accelerated 2-3 years before diagnosis, and verbal intelligence declined in close proximity to diagnosis. This cognitive profile is compatible with pathologic data suggesting that structures which mediate memory are affected earlier than frontal structures during the preclinical onset of AD. It also supports the view that VIQ as estimated by the AMNART does not decline during the preclinical onset of AD. (JINS, 2008, 14, 266-278.)

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Section: Fcsrtmentioning

confidence: 99%

Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease

Grober

Hall

Lipton

et al. 2008

J. Inter. Neuropsych. Soc.

353

314

View full text Add to dashboard Cite

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“…This amnestic form of AD has been associated with neuropathological changes of the anatomical structures related to episodic memory, mainly the hippocampi and other structures of the medial temporal lobes [5,6]. In particular, dysfunction of the hippocampal complex in AD leads to a specific episodic memory impairment characterized by a diminished free recall that is only marginally improved by providing a cue [7]. Such memory impairment can be better detected using a cued recall assessment, which is capable of isolating AD-typical hippocampal involvement in the most effective manner, increasing the accuracy of the diagnosis in AD [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…In this respect, the Free and Cued Selective Reminding Test (FCSRT), a cued recall evaluation for episodic memory, has proven to be an effective tool to detect AD at its early stages [10,11], and predict future cases of AD dementia [7,12,13]. It identifies patients with mild cognitive impairment (MCI) who are at a higher risk for developing AD [7] and also differentiates AD from other types of dementia [14,15].…”

Section: Introductionmentioning

confidence: 99%

Neuroanatomical Comparison of the “Word” and “Picture” Versions of the Free and Cued Selective Reminding Test in Alzheimer’s Disease

Slachevsky

Barraza

Hornberger

et al. 2017

JAD

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Abstract. Episodic memory tests with cued recall, such as the Free and Cued Selective Reminding Test (FCSRT), allow for the delineation of hippocampal and prefrontal atrophy contributions to memory performance in Alzheimer's disease (AD). Both Word and Picture versions of the test exist but show different profiles, with the Picture version usually scoring higher across different cohorts. One possible explanation for this divergent performance between the different modality versions of the test might be that they rely on different sets of neural correlates. The current study explores this by contrasting the neural correlates of the Word and Picture versions of the FCSRT with voxel-based morphometry (VBM) in AD and healthy subjects. We predicted that the Picture version would be associated with different cortical regions than the Word version, which might be more hippocampal-centric. When comparing 35 AD patients and 34 controls, AD patients exhibited impairments on both versions of the FCSRT and both groups performed higher in the Picture version. A region of interest analysis based on prior work revealed significant correlations between free recall of either version with atrophy of the temporal pole and hippocampal regions. Thus, contrary to expectations, performance on both the Word and the Picture version of the FCSRT is associated with largely overlapping networks. Free recall is associated with hippocampal volume and might be properly considered as an indicator of hippocampal structural integrity.

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“…Tests like the FCSRT and the MIS, which use controlled learning, powerfully discriminate between normal aging and dementia (Buschke, 1984;Buschke et al, 1995Buschke et al, , 1999Gebner et al, 1997;Grober et al, 1988Grober et al, , 2000Grober & Kawas, 1997;Ferris et al, 2006, Neuropsychological strategies for detecting early dementia 137 Peterson et al, 1994Peterson et al, , 1995Tounsi et al, 1999;Tuokko & Crockett, 1989). FCSRT, the memory test used here, has high sensitivity and specificity for the identification of dementia (Ferris et al, 2006;Gebner et al, 1997;Grober et al, 1988;Peterson et al, 1994;Tuokko & Crockett, 1989), and preclinical dementia (Grober & Kawas, 1997;Grober et al, 2000;Peterson et al, 1995;Robert et al, 2006;Sarazin et al, 2007). The controlled learning procedures minimize any influence of toxic-metabolic disorders on measures of memory performance, thereby reducing false-positive rates (Grober et al, 1989).…”

Section: Discussionmentioning

confidence: 99%

Neuropsychological strategies for detecting early dementia

Grober

Hall

Mcginn

et al. 2007

J Int Neuropsychol Soc

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As new and more effective treatments for Alzheimer's disease (AD) emerge, the development of efficient screening strategies in educationally and racially diverse primary care settings has increased in importance. A set of candidate screening tests and an independent diagnostic assessment were administered to a sample of 318 patients treated at a geriatric primary care center. Fifty-six subjects met criteria for dementia. Exploratory analysis led to the development of three two-stage screening strategies that differed in the composition of the first stage or Rapid Dementia Screen, which is applied to all patients over the age of 65. The second stage, applied to those patients who screen positively for dementia, is accomplished with the Free and Cued Selective Reminding Test to detect memory impairment. Using clinical diagnosis as a gold standard, the strategies had high sensitivity and specificity for identifying dementia and performed better for identifying AD than non-AD dementias. Sensitivity and specificity did not differ by race or education. The strategies provide an efficient approach to screening for early dementia.

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Amnestic syndrome of the medial temporal type identifies prodromal AD

Abstract: The amnestic syndrome of the medial temporal type, defined by the Free and Cued Selective Recall Reminding Test, is able to distinguish patients at an early stage of Alzheimer disease from mild cognitive impairment non-converters.

Cited by 416 publications

References 42 publications

Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease

Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease

Neuroanatomical Comparison of the “Word” and “Picture” Versions of the Free and Cued Selective Reminding Test in Alzheimer’s Disease

Neuropsychological strategies for detecting early dementia

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