Amniocentesis: A contemporary review

Connolly, Katherine A.

doi:10.5317/wjog.v5.i1.58

Cited by 9 publications

(11 citation statements)

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“…Muchos son los factores que podrían estar involucrados en las discrepancias entre los resultados encontrados en diferentes centros de diagnóstico prenatal. Las características de la población, la metodología utilizada, la edad gestacional de realización de los procedimientos y la institución donde ellos son ofrecidos pueden influir en la tasa de morbiletalidad asociada (5)(6)(7)34,35,42).…”

Section: Discussionunclassified

“…La Amniocentesis Tradicional (AT) fue el primer procedimiento invasivo utilizado para recolectar líquido amniótico destinado al análisis citogenético del feto. Se trata de una técnica relativamente simple cuya seguridad y confianza diagnóstica se encuentra bien establecida (1)(2)(3)(4)(5)(6). Aunque sea considerado patrón, el procedimiento es limitado pues sólo puede realizarse en el segundo trimestre del embarazo y la edad gestacional en que se encuentra la paciente cuando los resultados son suministrados varía entre las semanas 17 y 18 (7).…”

Section: Introductionunclassified

“…Los primeros estudios relatando la experiencia brasilera fueron publicados poco tiempo después (8)(9)(10). La AP puede ser realizada a partir de la semana 12 de gestación; su seguridad ha sido defendida y cuestionada desde su establecimiento por las intercurrencias asociadas (6,(11)(12)(13).…”

Section: Introductionunclassified

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Amniocentesis precoz y biopsia de vellosidad corial. Pérdidas fetales y anomalías congénitas en un grupo de gestantes brasileñas

Bernal¹,

Bernal²,

Gollop³

2018

nova

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En el Instituto de Medicina Fetal y Genética Humana de São Paulo se ofrecen, a las gestantes que tienen un riesgo aumentado para anomalías cromosómicas, diferentes técnicas, entre ellas, la Biopsia de Vellosidad Corial Transabdominal (BVCTA) y la Amniocentesis Precoz (AP). El objetivo del presente estudio es realizar una comparación de la frecuencia de pérdidas fetales y anomalías congénitas presentadas en cada uno de los procedimientos, ambos realizados por los mismos operadores, en la misma edad gestacional (12-14 6/7 semanas) y bajo un abordaje transabdominal. Fueron analizadas retrospectivamente 432 AP y 418 BVCTA. Todos los procedimientos de colecta fueron monitorizados por ultrasonografía. La frecuencia de pérdidas fetales espontáneas fue del 4,9 % en AP y de 5,3 % en BVCTA, una diferencia no significativa. No se encontraron diferencias significativas entre los dos procedimientos al comparar las frecuencias de pérdidas en cada semana de gestación. Sangrado y pérdida de líquido amniótico fueron más frecuentes en AP que en la BVCTA. Esa diferencia fue significativa en el caso de la pérdida de líquido amniótico. En algunoscasos este hallazgo se relacionó con pérdida fetal. La incidencia de prematuridad y bajo peso al nacimiento no difirió significativamente entre los dos procedimientos. La mayor frecuencia de problemas respiratorios registrada en AP no fue significativa en comparación con BVCTA. No se observó diferencia significativa en la incidencia de anomalías músculo-esqueléticas. La amniocentesis después de catorce semanas presenta un bajo riesgo de pérdida fetal o anomalías congénitas. La BVCTA, debe ser realizada alrededor de la semana doce de gestación.

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Section: Discussionunclassified

Section: Introductionunclassified

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Amniocentesis precoz y biopsia de vellosidad corial. Pérdidas fetales y anomalías congénitas en un grupo de gestantes brasileñas

Bernal¹,

Bernal²,

Gollop³

2018

nova

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“…Amniocentesis is the first invasive procedure used to diagnose and treat fetal diseases during pregnancy. (Connolly & Eddleman, 2016) It is currently the most common invasive genetic test in pregnant women. Amniocentesis is used as a basic invasive method for early detection of various pregnancy-related conditions, such as fetal karyotype, diagnosis of metabolic or enzymatic diseases, evaluation of severe hemolytic diseases, development of pulmonary maturation and diagnosis of fetal infections (Jummaat, Ahmad, & Ismail, 2019;Drukker, Sela, Ioscovich, Samueloff, & Grisaru-Granovsky, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…The Centers for Disease Control and Prevention (CDC) estimates that the rate of fetal loss after amniocentesis is 0.5%. Despite the fact that these studies were not random and that amniocentesis was not performed using ultrasound at the same time, this CDC estimate of post-amniocentesis abortion is still being used (Connolly & Eddleman, 2016). The importance of fetal loss after amniocentesis in twin pregnancies is very important to consultants, but few studies have examined the risk of fetal loss in amniocentesis in twin pregnancies, and some researchers believe that in twin pregnancies, the risk of fetal loss after amniocentesis is higher than singleton (Enzensberger, Pulvermacher, Degenhardt, Kawecki, Germer, Weichert, Krapp, Gembruch, & Axt-Fliedner, 2014;Wilson, Gagnon, Audibert, Campagnolo, Carroll, Brock, Chong, Johnson, MacDonald, Okun, & Pastuck, 2015).…”

Section: Introductionmentioning

confidence: 99%

Risk of Fetal Loss after Amniocentesis in Twins Comparing with Singleton Pregnancy

Masihi¹,

Shahbazian²,

Barati³

et al. 2020

JMBR

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Introduction: Amniocentesis is one of the most widely used diagnostic interventions but despite its many advantages, it has side effects such as fetal loss. The importance of fetal loss after amniocentesis in twin pregnancies is very important and some researchers believe that in twin pregnancies, the risk of fetal loss after amniocentesis is higher than singleton. Therefore, the present study examined the rate of fetal loss after amniocentesis in twin pregnancies compared to singleton pregnancies. Methods: This prospective descriptive-analytical study was performed on 712 mothers with singleton (628 cases) and twin (84 cases) pregnancies who referred to the obstetrics and gynecology clinic of Imam Khomeini Hospital in Ahvaz with Amniocentesis due to several reason during 2016-2020. A questionnaire containing information such as age, gestational age, number of pregnancies, childbirth and abortion, the cause of the diagnostic test, quarterly screening and NT ultrasound, and the result of amniocentesis were completed for patients. Patients were followed up during the first week, two weeks, and 60 days after amniocentesis, and finally data were analyzed by SPSS version24. Results: The mean age of the patients was 31.96 ± 6.33 years and the mean gestational age at amniocentesis for all patients was 15.37 ± 0.7. The mean NT in patients in the two groups did not differ significantly (1.60±0.44 vs 1.54±4.64, p=0.56). the prevalence of preterm in twin mothers was 13.1% and, in the singleton was 1.75% (p = 0.01). The occurrence of fetal loss was 2.4% in the twin group and 2.07% in the singleton group which was not statistically significant (p = 0.56). in the twin group, one (50%) fetal loss occurred in the first week and another one (50%) occurred between 15 and 60 days. But in the singleton group, 7 cases (63.6%) in the first week, 1 case (9%) in 15 to 60 days, and 3 cases (27.3) after more than 60 days lost the fetus. Previous pregnancy records in twins showed that the mean Gravid (p = 0.01), Parity (p = 0.01) and Living child (p = 0.02) in preterm twins' patients were statistically significantly lower than in the term patients. Conclusion: Our findings show that fetal loss following amniocentesis in twin pregnancies does not increase significantly compared to singleton pregnancies. However, our findings require repeated study in bigger sample size and as multi-centered as possible then It can be generalized to wider communities.

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Evaluation of short‐term safety of ultrasound‐guided foetal fluid sampling in the dog (Canis lupus familiaris)

2021

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Background: In humans, analysis of amniotic fluid is widely used for diagnostic and prognostic purposes. Amniocentesis has scarcely been used in veterinary medicine to date, despite a tremendous potential for clinical and research applications in dogs. Our study aimed to establish a safe method for foetal fluid sampling in female dogs. Methods: Two transabdominal ultrasound-guided methods were assessed: the "free hand" and the needle-guided bracket sampling. In addition, through a subsequent routinely scheduled ovariohysterectomy, fluid was directly collected. Samples from 98 conceptuses were collected at day 46.7 ± 7.5 of pregnancy. Results: The amount of fluid retrieved varied between 0.5 and 5.0 ml per collection. Macroscopic examination of the uterus and conceptuses identified 53% of the puncture sites. Neither fluid leakage nor foetal injury was detected, and six hematomas (5.8%) were visible. Ultrasound-guided foetal fluid collection was found to be potentially safe, and it can be performed by using either transabdominal method. Conclusion: Foetal fluid collection is possible with relative ease and low short-term risk, and may open paths for diagnostic, therapeutic and research purposes in dogs. The procedure can provide new insights into prenatal clinical medicine, including diagnostics of foetal deaths, early identification of heritable diseases and so on.

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Amniocentesis: A contemporary review

Cited by 9 publications

References 0 publications

Amniocentesis precoz y biopsia de vellosidad corial. Pérdidas fetales y anomalías congénitas en un grupo de gestantes brasileñas

Amniocentesis precoz y biopsia de vellosidad corial. Pérdidas fetales y anomalías congénitas en un grupo de gestantes brasileñas

Risk of Fetal Loss after Amniocentesis in Twins Comparing with Singleton Pregnancy

Evaluation of short‐term safety of ultrasound‐guided foetal fluid sampling in the dog (Canis lupus familiaris)

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