Amniotic epithelial cells damage by oxidative stress in cases of diffuse chorioamniotic hemosiderosis

Iizuka, Takashi; Ono, Masanori; Masumoto, Sakiko; Mitani, Yusuke; Yamazaki, Rena; Fujiwara, Hiroshi

doi:10.1111/jog.14084

Cited by 6 publications

(3 citation statements)

References 15 publications

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“…Cystic adenomyosis and endometriotic cysts are characterized by the retention of bleeding contents within the cyst for a long period of time. Furthermore, of the 16 cases of malignant cystic adenomyosis that have been reported, 8 cases were clear cell carcinomas, which is consistent with the most common histological type of ovarian cancer derived from endometriotic cysts (3). The present report focused on these similarities and further proposed some of the mechanisms underlying the malignant transformation of cystic adenomyosis in this case.…”

Section: Introductionsupporting

confidence: 80%

“…Subsequently, the degree of oxidative stress in cystic adenomyosis and cancer cell lesions was evaluated by the immunohistochemical staining of 8-hydroxy-20-deoxyguanosine (8-OHdG; a marker of DNA oxidative stress) and 4-hydroxy-2-nonenal (4-HNE; a marker of late-stage of lipid peroxidation). Immunohistochemical staining for 8-OHdG was performed using the standard avidin-biotin complex peroxidase method, as described previously with a minor modification ( 3 ). Briefly, endogenous peroxidase blocking with 3% hydrogen peroxide was not performed because the hydroxy radicals generated from hydrogen peroxide can react directly with the normal deoxyguanosine in tissues to produce 8-OHdG.…”

Section: Case Reportmentioning

confidence: 99%

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Occult clear cell carcinoma arising from oxidative stress‑exposed cystic adenomyosis: A case report

Hoshiba,

Kayahashi,

Hayashi

et al. 2024

Mol Clin Oncol

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Although adenomyosis is a benign uterine disease, it can turn malignant in rare instances. Cystic adenomyosis is a rare variation of adenomyosis, arising from which 8 cases of clear cell carcinoma have been reported. However, to the best of our knowledge, there have been no previous reports describing the mechanism by which clear cell carcinoma develops from cystic adenomyosis. The present report documents a case of a 73-year-old woman who was referred to Kanazawa University Hospital (Kanazawa, Japan) because of cystic adenomyosis, with a solid part inside the cyst. The patient was diagnosed with cystic adenomyosis at Shonan Obstetrics and Gynecology Hospital (Hakusan, Japan) 17 years prior; however, the size of the cyst increased after menopause. Therefore, malignant transformation was suspected, which warranted simple abdominal hysterectomy and bilateral salpingo-oophorectomy. The final diagnosis of the present case was uterine corpus cancer, clear cell carcinoma, stage IA. Immunohistochemical staining revealed that the normal and transitional atypical epithelial cells lining the cyst wall, in addition to the clear cell carcinoma cells (which were inside mural nodules located on the cyst wall), were positive for 8-hydroxy-20-deoxyguanosine. This observation suggested the presence of chronic oxidative stress around the cystic adenomyosis. Therefore, the present case suggests the possible involvement of chronic oxidative stress in the malignant transformation of cystic adenomyosis to clear cell carcinoma. This mechanism of malignant transformation of cystic adenomyosis appears to be similar to that of the malignant transformation of endometriotic cysts. Therefore, if the size of the cystic adenomyosis increases after menopause or if the solid part appears in the cyst in future cases, then the possibility of malignant transformation should be considered.

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Section: Introductionsupporting

confidence: 80%

Section: Case Reportmentioning

confidence: 99%

Occult clear cell carcinoma arising from oxidative stress‑exposed cystic adenomyosis: A case report

Hoshiba,

Kayahashi,

Hayashi

et al. 2024

Mol Clin Oncol

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“…Damage to amnion, fetal alveolar epithelial cells, and fetal pulmonary arterioles has been reported in cases of DCH. 10,11 Necrosis of the amnion was seen in 3% of placentas with DCH. 12 The reduction of ferric iron (Fe 3+ ) to ferrous iron (Fe 2+ ) may release reactive oxygen species, another potential mechanism of damage.…”

Section: Discussionmentioning

confidence: 99%

High-Grade Fetal Vascular Malperfusion Is Associated With Diffuse Chorionic Hemosiderosis

Mooney

Crotty

2021

Pediatr Dev Pathol

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Introduction Diffuse chorionic hemosiderosis (DCH) is an abnormality of the placental membranes characterized by the deposition of iron pigment. It is usually secondary to recurrent venous bleeding in early pregnancy. In many papers, it is associated with pre-term delivery. Fetal vascular malperfusion (FVM) is an abnormality of the feto-placental circulation that may be seen at any stage of gestation, but most often in the third trimester. It may be graded as low grade (LGFVM) or high grade (HGFVM). No link has been identified in the placental literature between DCH and FVM, but we have noted the 2 co-existing in placentas submitted for analysis. This study explored a possible association of these 2 entities. Methods Laboratory records were searched for singleton cases coded as DCH based on diagnosis on H&E stain over a 6-year period. Of 4478 placentas reported, 66 cases were coded as DCH (1.5%). These were classified as showing HGFVM, LGFVM, or no FVM. Controls (n = 132) were gestational age-matched cases without DCH. Cord length, coiling, insertion, or other abnormalities were noted. Membranes were classified as normal or circumvallate. Results were analyzed using Graphpad. Results Gestation ranged between 16 and 41 weeks gestation. 14/66 (21%) cases of DCH showed HGFVM and 2/66 (3%) showed LGFVM. 16/132 (12%) controls showed HGFVM and 21/132 (15.9%) had LGFVM. Where FVM is present, high-grade FVM is significantly associated with DCH versus controls ( P < .0031 Fischer’s Test). Discussion HGFVM occurs significantly more often in placentas with DCH than in controls. Both FVM and DCH are associated with adverse perinatal outcomes, and a possible relationship between the 2 remains to be clarified.

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Histological distribution pattern of hemosiderin deposition on the chorionic plate and fetal membrane of diffuse chorioamniotic hemosiderosis related to chronic abruption oligohydramnios sequence

et al. 2021

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Amniotic epithelial cells damage by oxidative stress in cases of diffuse chorioamniotic hemosiderosis

Cited by 6 publications

References 15 publications

Occult clear cell carcinoma arising from oxidative stress‑exposed cystic adenomyosis: A case report

Occult clear cell carcinoma arising from oxidative stress‑exposed cystic adenomyosis: A case report

High-Grade Fetal Vascular Malperfusion Is Associated With Diffuse Chorionic Hemosiderosis

Histological distribution pattern of hemosiderin deposition on the chorionic plate and fetal membrane of diffuse chorioamniotic hemosiderosis related to chronic abruption oligohydramnios sequence

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