Amniotic Fluid Embolism

Nawaz, Nadia; Buksh, Ahmed Raheem

doi:10.29271/jcpsp.2018.06.s107

Cited by 4 publications

(2 citation statements)

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“…Treatment of amniotic fluid embolism, due to its urgency and high mortality rate, should initially be supportive and focus on rapid stabilization of the mother's cardiorespiratory system and adequate oxygenation of vital organs (Table 4). There is no special treatment.The key to treatment is immediate recognition of the syndrome and a high rate of clinical suspicion [37,38]. In the past, the first actions were limited to the use of morphine, atropine and oxygen.…”

Section: Treatmentmentioning

confidence: 99%

Amniotic fluid embolism: A rare and destructive obstetric complication

Thanasa¹,

Thanasa²,

Gerokostas³

et al. 2022

Magna Sci. Adv. Res. Rev.

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Amniotic fluid embolism is a rare, unpredictable and often catastrophic obstetric complication that usually occurs during labor or caesarean section. The pathogenetic mechanism has not been fully elucidated to date. Amniotic fluid embolism is believed to happen due to an anaphylactic reaction to embryonic antigens that enter the mother's circulation and trigger a variety of immune processes that produce an anaphylactic-like response. The diagnosis remains clinical. The disease manifests abruptly with cardiovascular shock, encephalopathy, fetal discomfort and disseminated intravascular coagulation. There is no special treatment. The treatment is supportive and focuses on rapid stabilization of the cardiopulmonary system, adequate oxygenation of the vital organs and correction of coagulation, ensuring the best possible perinatal outcome. In this article, based on current data, a literature review of this rare obstetric complication is attempted, particularly with regard to diagnosis and the basic treatment principles, the timely and correct application of which can provide the best possible outcome for the mother and the newborn.

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Section: Treatmentmentioning

confidence: 99%

Amniotic fluid embolism: A rare and destructive obstetric complication

Thanasa¹,

Thanasa²,

Gerokostas³

et al. 2022

Magna Sci. Adv. Res. Rev.

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show abstract

“…The pathogenetic pathway involves an inflammatory anaphylactoid response to fetal antigens, which occurs due to the disruption in the maternal-fetal barrier at delivery and leads to increased pulmonary and/or systemic vascular resistance, decreased left ventricular function and coagulopathy. The patient presents clinical signs of respiratory failure and cardiogenic shock with severe hypoxia, hemodynamic collapse and coagulopathy (37,38). There is no gold-standard approach for the diagnosis of the disease, and in the majority of cases, the diagnosis is based on clinical signs and symptoms (39).…”

Section: Non-obstetric Indicationsmentioning

confidence: 99%

Role of Critical Care Units in the management of obstetric patients (Review)

et al. 2021

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Pregnancy is considered a natural process for the majority of women. However, a limited proportion of pregnancies and deliveries can present with a broad variety of complications that may require admission to a Critical Care Unit (CCU). In the present review, the indications of admission of obstetrical and postpartum patients to CCUs were critically evaluated with a particular focus on the management of their complications. The management of critically ill obstetric patients remains challenging due to the physiological changes that occur during pregnancy, pregnancy-related diseases and the need to carefully consider the well-being of the fetus before any intervention can be recommended/performed. Indications for admission to CCUs include both obstetric and non-obstetric conditions that may require continuous monitoring and further interventions. Hypertensive disorders of pregnancy and mass hemorrhage are amongst the most common causes of admission to CCUs in pregnant and postpartum women. The establishment of a diagnostic and care algorithm based on the contribution of a multidisciplinary team is of critical importance to aid in the determination of which patients will require intensive care, and to assist in deciding what type of critical care each critically ill patients receives.

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Amniotic fluid embolism: a reappraisal

Young,

Florine Magdelijns,

Chervenak

et al. 2023

Journal of Perinatal Medicine

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Objectives Using cases from our own experience and from the published literature on amniotic fluid embolism (AFE), we seek to improve on existing criteria for diagnosis and discern associated risk factors. Additionally, we propose a novel theory of pathophysiology. Methods This retrospective case review includes eight cases of AFE from two hospital systems and 21 from the published literature. All cases were evaluated using the modified criteria for research reporting of AFE by Clark et al. in Am J Obstet Gynecol, 2016;215:408–12 as well as our proposed criteria for diagnosis. Additional clinical and demographic characteristics potentially correlated with a risk of AFE were included and analyzed using descriptive analysis. Results The incidence of AFE was 2.9 per 100,000 births, with five maternal deaths in 29 cases (17.2 %) in our series. None of the cases met Clark’s criteria while all met our criteria. 62.1 % of patients were over the age of 32 years and two out of 29 women (6.9 %) conceived through in-vitro fertilization. 6.5 % of cases were complicated by fetal death. Placenta previa occurred in 13.8 %. 86.2 % of women had cesarean sections of which 52.0 % had no acute maternal indication. Conclusions Our criteria identify more patients with AFE than others with a low likelihood of false positives. Clinical and demographic associations in our review are consistent with those previously reported. A possible relationship between cesarean birth and risk of AFE was identified using our criteria. Additionally, we propose a new hypothesis of pathophysiology.

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Amniotic Fluid Embolism

Cited by 4 publications

References 0 publications

Amniotic fluid embolism: A rare and destructive obstetric complication

Amniotic fluid embolism: A rare and destructive obstetric complication

Role of Critical Care Units in the management of obstetric patients (Review)

Amniotic fluid embolism: a reappraisal

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