Amniotic fluid lamellar body concentration as a marker of fetal lung maturity at term elective caesarean delivery

Walker, Susan; Chow, Yvonne Y. C.; Ugoni, Antoni; Holberton, James; Smith, Carole L.; Permezel, Michael

doi:10.1111/j.1479-828x.2010.01199.x

Cited by 4 publications

(5 citation statements)

References 25 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, the concentration of lamellar bodies, composing of surfactant, has been evaluated for determining lung maturity in gastric aspirates and in amniotic fluid. 13,14 The present study cannot answer the question of lung or surfactant maturity directly, but it demonstrates that the surface activity of upper airway aspirates clearly shows significant differences between mature and immature surfactant systems as it reflects the clinical course of the neonates. However, the present processing time of $2 hr is too long to apply the test in clinical practice, since most of the neonates need immediate treatment.…”

Section: Discussionmentioning

confidence: 59%

“…Considering the consequences or the additional information that a biomarker for lung maturity preferably could give neonatologists, it should be a simple marker that helps to avoid secondary deterioration of moderate RDS, that is, that tells us who of the CPAP treated neonates is going to need secondary intubation, ventilation, and surfactant treatment. Recently, the concentration of lamellar bodies, composing of surfactant, has been evaluated for determining lung maturity in gastric aspirates and in amniotic fluid . The present study cannot answer the question of lung or surfactant maturity directly, but it demonstrates that the surface activity of upper airway aspirates clearly shows significant differences between mature and immature surfactant systems as it reflects the clinical course of the neonates.…”

Section: Discussionmentioning

confidence: 68%

See 1 more Smart Citation

Surface tension of airway aspirates withdrawn during neonatal resuscitation reflects lung maturity

et al. 2013

View full text Add to dashboard Cite

The indications for treatment of neonates with exogenous pulmonary surfactant are still discussed controversially. Some premature neonates are sufficiently treated by CPAP, others need conventional ventilation and/or surfactant. The available lung maturity tests have limitations. The captive bubble surfactometer (CBS) provides measurement of surface activity from rather small amounts of surfactant. This study aimed to determine surface activity from small volume aspirates of the upper airways of neonates by means of the CBS and to correlate the results with clinical data. Small upper airway aspirates from 159 neonates (gestational age 25-42 weeks) were withdrawn and concentrated 16.7-fold by ultracentrifugation and resuspension in saline. Surface activities after 5 min of adsorption were determined in the CBS and correlated to the perinatal data (e.g., gestational age, birth weight, gender), airway interventions (like CPAP, conventional ventilation) and surfactant treatment. Additionally, 27 samples were analyzed for surfactant specific phosphatidylcholine concentrations by using electrospray ionization tandem mass-spectroscopy. Surface activities show a significant correlation to gestational age, birth weight, and the need for airway interventions. Comparing the need for airway interventions versus surface activity, a receiver operating characteristic calculated a sensitivity of 0.77 and a specificity of 0.72 at a "cut off" of 44 mN/m. Surface activity correlates significantly with the phosphatidylcholine concentrations and the latter one correlates with the gestational age. Determination of surface activity from upper airway aspirates is feasible. Further clinical studies are needed to prove the predictive value of the method.

show abstract

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 68%

Surface tension of airway aspirates withdrawn during neonatal resuscitation reflects lung maturity

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The group we examined is not large, but it is comparable to the groups examined by others [4,7,8]. Due to the rare indications for performing CAT scanning in neonates, many authors enlarge their groups with older children [6,9].…”

Section: Discussionmentioning

confidence: 68%

Diagnostic imaging Comparative analysis of imaging examinations of the thoracic cage in neonates. Defining indications for cat scanning

Sraga¹,

Głowacki²,

Kluczewska³

et al. 2013

kitp

View full text Add to dashboard Cite

StreszczeniePodstawowym badaniem służącym do diagnozowania dzieci z różnego typu zaburzeniami oddychania jest zdjęcie radiologiczne klatki piersiowej. Mimo wciąż malejącej roli, jaką odgrywa radiologia klasyczna w diagnostyce obrazowej, zdjęcie RTG jest zasadniczo nadal jedyną dostępną metodą obrazowania patologii płucnych u noworodków. Natomiast w sytuacjach, gdy klasyczna metoda wydaje się niewystarczająca, należy rozważyć wykonanie tomografii komputerowej. W artykule opisano wybór grupy noworodków, u której wykonanie TK było wskazane. Przy wyborze należało uwzględnić wiele czynników. Najistotniejszym kryterium był stan ogólny noworodka oraz korzyść płynąca z badania, która musi przewyższać czynniki ryzyka i konsekwencje pochłonięcia dużej dawki promieniowania jonizującego. Celem pracy było określenie wskazań do wykonania tomografii komputerowej klatki piersiowej u dzieci w okresie noworodkowym na podstawie materiału pochodzą-cego z ośrodka, w którym pracują autorzy artykułu. Na podstawie przeprowadzonych badań wyciągnięto wnioski zawarte w pracy. Słowa kluczowe: noworodki, zdjęcie RTG klatki piersiowej, tomografia komputerowa klatki piersiowej.Kardiochirurgia i Torakochirurgia Polska 2013; 10 (3) 295 DIAGNOSTIC IMAGING AbstractAn X-ray of the thoracic cage is a fundamental examination in children with disorders of various origin. Despite the constantly decreasing role of classic radiology in imaging diagnostics, the X-ray photograph still remains the only method available in practice for imaging lung pathologies in neonates. The aim of the work is to define the indications for performing CAT scanning of the thoracic cage in children in the neonatal period on the basis of our own material. We analysed a group of neonates referred for thoracic cage CAT scanning. Out of 10 people examined, 8 were boys, and 2 were girls. Respiratory disorders or the presence of auscultatory phenomena were an indication for making an X-ray in neonates in whom a CAT scan of the thoracic cage was done. All neonates from the examined group had an X-ray only as a result of above-mentioned indications. On the basis of a classic X-ray photograph, it was not possible to differentiate the flaccidity of the diaphragm with diaphragmatic hernia; the suspicion of presence of patent emphysema ventricle also needed to be confirmed. In one neonate, X-ray gave the image of an enlarged cone of the heart, and in the subsequent one, the image of persistent atelectasis of the right lower lobe. On the basis of the centre's experience, we may draw the conclusions that the basic indication for performing CAT scan examination in neonates is the suspicion of anatomical irregularity mentioned in the paper.

show abstract

“…Walker et al [18] examined the link between amniotic fluid LBC and risk factors for respiratory distress in term cesarean births. Since the study was retrospective, the study groups could not be formed more homogeneously and this can be considered as a limitation.…”

Section: Discussionmentioning

confidence: 99%

Fetal lung maturity assessment with lamellar body count in women with obesity and excessive gestational weight gain

Ocal,

Tekin,

Guleroglu

et al. 2023

Med-Science

View full text Add to dashboard Cite

The aim of this study was to evaluate fetal lung maturation in term pregnant women with obesity and excessive gestational weight gain using the lamellar body count (LBC) test in amniotic fluid samples obtained during cesarean section. This retrospective study included women experiencing term pregnancies and undergoing cesarean delivery, categorized as normal weight (n=37), overweight (n=59), or obese (n=48) due to body mass index values of 18.5 to 24.9; 25 to 29.9; and ≥30, respectively, as well as presence of excessive weight gain during pregnancy. During cesarean delivery, amniotic fluid samples were obtained without contamination of blood or meconium. Lamellar bodies in these samples were quantified using a standard hematologic counter. No significant difference was found among the LBC of the normal weight, overweight, and obese groups [42 (32-60), 40 (26-63), and 43 (24-52) x103/µL; p=0.307], although there was a subtle decrease in the LBC of the obese group with excessive weight gain. Although it is noteworthy that the LBC in the amniotic fluid of mothers with obesity and excessive weight gain during pregnancy showed a partial decrease, this decrease did not reach statistical significance, likely due to the relatively low number of cases in the study groups. Additional research is warranted to elucidate the relationship between LBC alterations and the severity of obesity and weight gain during pregnancy.

show abstract

Amniotic fluid lamellar body concentration as a marker of fetal lung maturity at term elective caesarean delivery

Cited by 4 publications

References 25 publications

Surface tension of airway aspirates withdrawn during neonatal resuscitation reflects lung maturity

Surface tension of airway aspirates withdrawn during neonatal resuscitation reflects lung maturity

Diagnostic imaging Comparative analysis of imaging examinations of the thoracic cage in neonates. Defining indications for cat scanning

Fetal lung maturity assessment with lamellar body count in women with obesity and excessive gestational weight gain

Contact Info

Product

Resources

About