Amniotic fluid soluble fas levels in intra-amniotic infection

Hsu, Chaur Dong; Hong, Shih Feng; Harirah, Hassan; Bahado‐Singh, Ray O.; Lu, Li

doi:10.1016/s0029-7844(99)00664-x

Cited by 9 publications

(5 citation statements)

References 14 publications

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“…However, soluble Fas, an alternatively spliced product of the Fas gene, protects the target cells from Fas-mediated apoptosis by neutralizing binding between membrane-bound Fas and the Fas ligand [ 126 ]. It has been proven that the concentration of soluble Fas in the amniotic fluid is high [ 127 ]. In addition, Fas has been shown to be expressed predominantly in epithelial cells throughout the whole amnion, so it is reasonable to hypothesize that hAESCs are one of the major sources of soluble Fas existing in the amniotic fluid [ 128 ].…”

Section: The Paracrine Effect Of Human Amniotic Epithelial Stem Cementioning

confidence: 99%

Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications

Qiu

Cui

et al. 2020

IJMS

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Perinatal stem cells have been regarded as an attractive and available cell source for medical research and clinical trials in recent years. Multiple stem cell types have been identified in the human placenta. Recent advances in knowledge on placental stem cells have revealed that human amniotic epithelial stem cells (hAESCs) have obvious advantages and can be used as a novel potential cell source for cellular therapy and clinical application. hAESCs are known to possess stem-cell-like plasticity, immune-privilege, and paracrine properties. In addition, non-tumorigenicity and a lack of ethical concerns are two major advantages compared with embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). All of the characteristics mentioned above and other additional advantages, including easy accessibility and a non-invasive application procedure, make hAESCs a potential ideal cell type for use in both research and regenerative medicine in the near future. This review article summarizes current knowledge on the characteristics, therapeutic potential, clinical advances and future challenges of hAESCs in detail.

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Section: The Paracrine Effect Of Human Amniotic Epithelial Stem Cementioning

confidence: 99%

Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications

Qiu

Cui

et al. 2020

IJMS

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“…Kubo et al transplanted human amnion to both the rat limbal area and under the kidney capsule and found that the xenogeneic (human to rat) immune responses were significantly mitigated [15]. In addition, all HLA-G, CD59, and FasL are secreted from hAECs into amniotic fluid [16,17]. These soluble factors provide immune tolerance not only to the transplanted hAECs but also to neighboring cells.…”

Section: Immune Privilegementioning

confidence: 99%

A Rational Strategy for the Use of Amniotic Epithelial Stem Cell Therapy for Liver Diseases

Miki

2016

Stem Cells Translational Medicine

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“…51,52 A previous report showed that soluble Fas (sFas) is elevated in the AF of patients with MIAC complicated by PTL or PPROM. 53 Balkundi et al also reported that increased trophoblast Fas expression and apoptosis are associated with severe acute HCA (grade 3). 54 Similar to these results, Annells et al reported that polymorphisms in FAS gene promoter are negatively associated with acute HCA in women with preterm birth.…”

Section: Discussionmentioning

confidence: 97%

“…Noteworthily, both Fas and Fas ligands are expressed in the human placenta and fetal membranes (amnion, chorion, and chorioamnion) during gestation 51,52 . A previous report showed that soluble Fas (sFas) is elevated in the AF of patients with MIAC complicated by PTL or PPROM 53 . Balkundi et al.…”

Section: Discussionmentioning

confidence: 99%

Plasma IGFBP‐1, Fas, kallistatin, and P‐selectin as predictive biomarkers of histologic chorioamnionitis and associated intra‐amniotic infection in women with preterm labor

Lee

Cho

et al. 2022

American J Rep Immunol

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Problem To determine whether altered levels of 13 plasma biomarkers, alone or in combination, could be independently associated with histologic chorioamnionitis (HCA) and microbial‐associated HCA (defined as the presence of HCA along with microbial invasion) in women with preterm labor (PTL). Methods of Study This was a retrospective cohort study involving 77 singleton pregnant women with PTL (23–34 gestational weeks) who delivered within 96 h of plasma and amniotic fluid (AF) sampling. DKK‐3, E‐selectin, Fas, haptoglobin, IGFBP‐1, kallistatin, MMP‐2, MMP‐8, pentraxin 3, progranulin, P‐selectin, SAA4, and TGFBI levels were assayed in plasma samples by ELISA. AF obtained via amniocentesis was used for microorganism identification. Results Multiple logistic regression analyses revealed significant associations between low plasma IGFBP‐1 levels and acute HCA, and between low plasma Fas and kallistatin levels, and elevated plasma P‐selectin levels and microbial‐associated HCA (all p < .05), after adjusting for gestational age. Using a stepwise regression procedure, a multi‐biomarker panel for microbial‐associated HCA was developed, which included plasma MMP‐2, kallistatin, and P‐selectin levels (area under the curve [AUC], .867). The AUC for this three‐marker panel was significantly or borderline significantly greater than that of any single variable included in the panel. However, a predictive model for acute HCA could not be developed because only one variable (MMP‐2) was selected. Conclusions These findings demonstrate that IGFBP‐1, Fas, kallistatin, and P‐selectin are associated with acute HCA and microbial‐associated HCA in women with PTL. Their combined use can significantly improve the diagnostic ability for the detection of microbial‐associated HCA.

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Amniotic fluid soluble fas levels in intra-amniotic infection

Abstract: Elevated AF sFas is associated with intra-amniotic infection. High production of AF sFas in intra-amniotic infection may play a role in the inhibition of apoptosis of AF leukocytes, leading to the persistence of inflammation.

Cited by 9 publications

References 14 publications

Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications

Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications

A Rational Strategy for the Use of Amniotic Epithelial Stem Cell Therapy for Liver Diseases

Plasma IGFBP‐1, Fas, kallistatin, and P‐selectin as predictive biomarkers of histologic chorioamnionitis and associated intra‐amniotic infection in women with preterm labor

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