Amniotic Membrane Transplantation in Treatment of Persistent Corneal Ulceration after Severe Chemical and Thermal Eye Injuries

Iakimenko, S.; Buznyk, Oleksiy; Rymgayłło-Jankowska, Beata

doi:10.5301/ejo.5000243

Cited by 23 publications

(11 citation statements)

References 20 publications

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“…Healing of this condition can be achieved by ATM. There are numbers of publications demonstrating that application of AM lead to improved or complete healing of the corneal ulcers (30,31,32,33,34). Again, our study confirmed the literature observations, as we reported here, that application of AM to our seven groups, which includes the major ophthalmological diseases, can severely improve the size of a corneal ulcer.…”

Section: Discussionsupporting

confidence: 91%

Amniotic membrane transplantation- excellent biological scaffold for anterior ocular surface reconstruction

Manolova

Popov²,

Grupcheva³

2016

SSM

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AIM: To evaluate the clinical effect and to determine the correlation between the initial pathology and postoperative outcome in patients with anterior surface dysfunction treated by amniotic membrane transplantation (AMT). MATERIALS AND METHODS: 174 AMT of cryopreserved amniotic membrane (AM) were performed on 128 patients over a period of two years (January, 2014-December, 2015). Patients were grouped into 7 cohorts according to the reasons for the AMT-A) corneal recurrent erosions (n=32), B) postoperative keratitis (n=7), C) neurotrophic ulcers (n=14), D) trauma and burns (n=30), E) bacterial keratitis (n=10), F) viral keratitis (n=19) and G) other (n=16). The groups were assessed for levels of pain (a subjective symptom) and hyperemia and size of the corneal ulcer (objective signs), and were compared on several stages before and after AMT-day 0, day 8 and day 25. RESULTS: The AM treatment resulted in significant reduction of the symptoms in all categories. On the 8 th day, the observed improvement was higher than 50% (100% for the pain, 50±10% for hyperemia and 60±15% for corneal ulcer) as at the end of our follow-up hyperemia improvement increased to 80±10% and corneal ulcer size decreased with 95±3%. Interestingly, in comparison to day 8, pain levels increased significantly after 25 days of AMT to 15±15%. CONCLUSION: АМТ is an effective method for managing pathological conditions resulting from a damage to the ocular surfaces such as unresponsiveness to common treatment, chronical or recurrent diseases, eye infection and stem cell deficiency. The application of this therapy can have permanent results, which lead to complete healing of the damaged eye or it can serve as a temporal procedure until reconstructive approach is possible. AMT is a treatment of choice in the cases where availability of corneal tissue is limited.

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Section: Discussionsupporting

confidence: 91%

Amniotic membrane transplantation- excellent biological scaffold for anterior ocular surface reconstruction

Manolova

Popov²,

Grupcheva³

2016

SSM

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“…Overall, treatment with glycerinepreserved amniotic membranes was less efficacious than described previously by different groups (Kruse et al 1999;Chen et al 2000;Prabhasawat et al 2001;Letko et al 2001;Fereira de Souza et al 2001;Dogru et al 2003;Chen et al 2006;Nubile et al 2011;Iakimento et al 2013;Berguiga et al 2013) . This may be due to the retrospective nature of our analysis: our patients were not regularly investigated, so treatment failures may have been diagnosed late.…”

Section: Discussionmentioning

confidence: 69%

“…Iakimento et al. () stated a re‐epithelialization rate of 76% of 55 eyes with corneal ulcers and limbal insufficiencies that had been treated with glycerine‐preserved amniotic membranes. They also reported that 12.5% of the corneas that did not epithelialize required reoperation and found later recurrence in 14.3% of re‐epithelialized corneas.…”

Section: Discussionmentioning

confidence: 99%

“…Successful epithelialization of the corneal surface following the use of mostly glycerine-preserved mono-or multilayer human amniotic membranes has been observed in several clinical investigations. These membranes were applied in patients who suffered from various diseases of the ocular surface: corneal epithelial defects (Prabhasawat et al 2001;Letko et al 2001), ulcers (Kruse et al 1999;Chen et al 2000;Fereira de Souza et al 2001;Hanada et al 2001;Dogru et al 2003;Chen et al 2006;Nubile et al 2011;Iakimento et al 2013;Berguiga et al 2013) or perforation (Chen et al 2006;M€ uller et al 2009). Regarding corneal re-epithelialization, success rates varied from 19% to 91% (Fereira de Souza et al 2001;Nubile et al 2011;Berguiga et al 2013), and improved visual acuity was found in 18-90% of patients (Fereira de Souza et al 2001;Dogru et al 2003;Prabhasawat et al 2001).…”

Section: Discussionmentioning

confidence: 99%

“…An exception is the series by Shukla (1962), who reported on 50 patients; however, these authors used non-preserved amniotic membranes and did not give any information regarding BCVA or recurrence. Iakimento et al (2013) stated a re-epithelialization rate of 76% of 55 eyes with corneal ulcers and limbal insufficiencies that had been treated with glycerinepreserved amniotic membranes. They also reported that 12.5% of the corneas that did not epithelialize required reoperation and found later recurrence in 14.3% of re-epithelialized corneas.…”

Section: Discussionmentioning

confidence: 99%

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Long‐term efficacy of glycerine‐processed amniotic membrane transplantation in patients with corneal ulcer

Uhlig¹,

Frings²,

Rohloff³

et al. 2015

Acta Ophthalmologica

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ABSTRACT.Purpose: The aim of this study was to determine the long-term treatment efficacy of glycerine-preserved human amniotic membrane transplantation in patients suffering from corneal ulcers. Methods: This was a retrospective, non-controlled, monocentric analysis. Included were patients with corneal ulcers that were non-responsive to ointment or contact lenses and had been treated by amniotic membrane transplantation with either the overlay or sandwich procedure. Analysis parameters were visual acuity before and following treatment, recurrence rate and subjective comfort at the last follow-up. Results: Of the 371 amniotic membrane transplantations that were conducted, 135 surgical treatments in 108 patients (51.9% male, 48.1% female; mean age 63.7 years) met the inclusion criteria. In total, 99 overlay and 36 multilayer amniotic membrane transplantations were performed. The follow-up period was 47.5 AE 66.7 weeks (mean AE SD). The recurrence rate at the last follow-up was 47.8% with overlay membranes and 51.8% with the sandwich technique. There was no significant change in best-corrected visual acuity following treatment with overlays (p = 0.219) or sandwich procedure (p = 0.703). At the last follow-up, 72.1% (overlay) and 78.3% (sandwich) of the patients reported either no pain or increased comfort. Conclusion: The recurrence rates and changes in visual acuity following overlay or sandwich amniotic membrane transplantation in patients suffering from corneal ulcer were lower than reported elsewhere in the literature. More than half of the patients profited from each of the amniotic membrane transplantation techniques with respect to recurrence and postoperative comfort.

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Diseases of the cornea

Brooks¹,

Matthews²,

Clode³

2016

Equine Ophthalmology

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Amniotic Membrane Transplantation in Treatment of Persistent Corneal Ulceration after Severe Chemical and Thermal Eye Injuries

Abstract: Amniotic membrane transplantation may stop ulceration and promote corneal epithelialization in the majority of patients with the most severe chemical or thermal eye injuries in case of timely application of the operation and adequate fixation of the AMT graft.

Cited by 23 publications

References 20 publications

Amniotic membrane transplantation- excellent biological scaffold for anterior ocular surface reconstruction

Amniotic membrane transplantation- excellent biological scaffold for anterior ocular surface reconstruction

Long‐term efficacy of glycerine‐processed amniotic membrane transplantation in patients with corneal ulcer

Diseases of the cornea

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