Amoebic Liver Abscess in African Children

Tinidazole in treatment of acute amoebic dysentery in children.

“…In African children, who are frequently malnourished and suffering from additional diseases, amoebic dysentery is a serious condition. The onset is often acute and should complications occur the prognosis is worse than in adults (Scragg, 1960;Wilmot, 1962;Scragg andPowell, 1966, 1970). Thus in the past it was our practice to use the combined regimen in all children with amoebic dysentery.…”

Emetine hydrochloride and chloroquine in the treatment of children with amoebic liver abscess.

“…When treated with combined emetine hydrochloride, chloroquine, and aspiration, the prognosis is excellent in adults (Wilmot, 1962), this regime being more successful than treatment with a single drug (Wilmot, Powell, and Adams, 1959;Wilmot, Powell, MacLeod, and Elsdon-Dew, 1964). In children our current therapy is similar to that employed successfully in adults, but our mortality has been over 50% (Scragg, 1960). In this short paper we compare the results of treatment in two groups of children with amoebic liver abscess, the one group treated with emetine hydrochloride and the other with chloroquine.…”