Amomum villosum Lour. Fruit extract mitigates hyperlipidemia through SREBP-2/LDLR/HMGCR signaling in high-cholesterol diet-fed mice

Kim, Ye-Seul; Kim, Ha-Rim; Antonisamy, Paulrayer; Lee, Young‐Rae; Lee, Guemsan; Jung, Hyun-Jong; Kwon, Kang‐Beom

doi:10.1016/j.jksus.2022.102230

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…Similar results were also found in the report by Fan et al ( 13 ) who found that catechin and epicatechin were the predominant phenolic compounds in Fr-EtOAc of A. tsaoko . Although some reports confirmed that the water extract of A. villosum had many biological activities ( 7 , 8 ), there was not much research on the composition of phenolic compounds from A. villosum . And this is the first time to report the composition of phenolic compounds from the seeds of A. villosum .…”

Section: Resultsmentioning

confidence: 99%

“…As previously reported, Tang et al ( 4 ) found that A. villosum volatile oil exhibited antibacterial activity by interfering with the metabolism of methicillin-resistant Staphylococcus aureus , and the report described by Liu et al ( 5 ) revealed that A. villosum polysaccharides could reduce gastric mucosal injury by promoting the level of reactive oxygen species and inflammatory factors. Although there were several studies on the biological activities of the water extract of A. villosum , including absorption characteristics ( 6 ), weight loss ( 7 ), mitigate hyperlipidemia ( 8 ), the composition of phenolic compounds from A. villosum was still unclear, which restricted the further utilization of A. villosum .…”

Section: Introductionmentioning

confidence: 99%

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Characterization, antioxidant and antitumor activities of phenolic compounds from Amomum villosum Lour.

Zhang,

Shuai,

Wei

et al. 2024

Front. Nutr.

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Amomum villosum Lour. (A. villosum), known as Sharen in China, is widely used for culinary and medicinal purposes due to containing a diverse set of bioactive compounds. In this study, the optimum ethanol extraction process was optimized and the composition and biological activities (antioxidant and antitumor) of five different fractions (dichloromethane, petroleum ether, ethyl acetate, n-butanol and H2O) extracted from the ethanol extract of A. villosum were investigated. The results showed that the optimal extraction conditions were extraction temperature 80°C, extraction time 120 min, ethanol concentration 40% and solid–liquid ratio 1:25 g/mL. Moreover, 35 bioactive compounds were successfully identified by UPLC-ESI-QTOF-MS/MS from five factions for the first time, including 12 phenolic acids and derivatives, 2 organic acids, 12 flavonoids and derivatives, 2 oxylipins and 7 proanthocyanidins. Among them, ethyl acetate fraction (Fr-EtOAc) exhibited the highest content of total phenolic (374.01 mg GAE/g DW) and flavonoid (93.11 mg RE/g DW), where vanillic acid, catechin, epicatechin and protocatechuic acid were the predominant phenolic compounds that accounting for 81.65% of the quantified bioactive compounds. In addition, Fr-EtOAc demonstrated excellent total antioxidant activity (IC50 of DPPH and ABTS assays were 0.23, 0.08 mg/mL, respectively, and FRAP assay was 322.91 mg VCE/100 g DW) and antitumor activity (1,000 μg/mL, 79.04% inhibition rate). The results could provide guidance for the industrial production and application of A. villosum.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization, antioxidant and antitumor activities of phenolic compounds from Amomum villosum Lour.

Zhang,

Shuai,

Wei

et al. 2024

Front. Nutr.

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“…However, some studies have revealed that its activation could be beneficial. For instance, drugs such as simvastatin can promote the levels of SREBP2 and LDLR to mitigate hyperlipidemia . Both PCSK9 and LDLR are transcriptionally regulated by SREBP2 to control lipid metabolism and maintain lipid homeostasis; therefore, the regulatory effect of phytochemicals on SREBP2, which may consequently affect PCSK9 and LDLR levels, should be evaluated.…”

Section: Regulation Of Cholesterol Homeostasismentioning

confidence: 99%

“…For instance, drugs such as simvastatin can promote the levels of SREBP2 and LDLR to mitigate hyperlipidemia. 30 Both PCSK9 and LDLR are transcriptionally regulated by SREBP2 to control lipid metabolism and maintain lipid homeostasis; therefore, the regulatory effect of phytochemicals on SREBP2, which may consequently affect PCSK9 and LDLR levels, should be evaluated. A study in 2021 demonstrated the regulatory effect of gypenosides on hepatic LDL, where no significant effect was observed in the expression of SREBP2, while the LDLR expression was upregulated, and the PCSK9 level was suppressed.…”

Section: Regulation Of Cholesterol Homeostasismentioning

confidence: 99%

Exploring Phytochemical Mechanisms in the Prevention of Cholesterol Dysregulation: A Review

Weerawatanakorn,

Kamchonemenukool,

Koh

et al. 2024

J. Agric. Food Chem.

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Although cholesterol plays a key role in many physiological processes, its dysregulation can lead to several metabolic diseases. Statins are a group of drugs widely used to lower cholesterol levels and cardiovascular risk but may lead to several side effects in some patients. Therefore, the development of a plant-based therapeutic adjuvant with cholesterol-lowering activity is desirable. The maintenance of cholesterol homeostasis encompasses multiple steps, including biosynthesis and metabolism, uptake and transport, and bile acid metabolism; issues arising in any of these processes could contribute to the etiology of cholesterolrelated diseases. An increasing body of evidence strongly indicates the benefits of phytochemicals for cholesterol regulation; traditional Chinese medicines prove beneficial in some disease models, although more scientific investigations are needed to confirm their effectiveness. One of the main functions of cholesterol is bile acid biosynthesis, where most bile acids are recycled back to the liver. The composition of bile acid is partly modulated by gut microbes and could be harmful to the liver. In this regard, the reshaping effect of phytochemicals on gut microbiota has been widely reported in the literature for its significance. Therefore, we reviewed studies conducted over the past 5 years elucidating the regulatory effects of phytochemicals or herbal medicines on cholesterol metabolism. In addition, their effects on the recomposition of gut microbiota and bile acid metabolism due to modulation are discussed. This review aims to provide novel insights into the treatment of cholesterol dysregulation and the anticipated development of natural-based compounds in the near and far future.

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Nutritional immunological effects and mechanisms of chemical constituents from the homology of medicine and food

Edo,

Ndudi,

Makia

et al. 2024

Phytochem Rev

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Amomum villosum Lour. Fruit extract mitigates hyperlipidemia through SREBP-2/LDLR/HMGCR signaling in high-cholesterol diet-fed mice

Cited by 6 publications

References 19 publications

Characterization, antioxidant and antitumor activities of phenolic compounds from Amomum villosum Lour.

Characterization, antioxidant and antitumor activities of phenolic compounds from Amomum villosum Lour.

Exploring Phytochemical Mechanisms in the Prevention of Cholesterol Dysregulation: A Review

Nutritional immunological effects and mechanisms of chemical constituents from the homology of medicine and food

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