Amorphization of drugs by adsorptive precipitation from supercritical solutions: A review

Gurikov, Pavel; Смирнова, Ирина

doi:10.1016/j.supflu.2017.03.005

Cited by 85 publications

(67 citation statements)

References 122 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The maximum amount reflects the maximum possible amount of the active substance at given process parameters, which is obtained when equilibrium is reached. The maximum amount depends on the external parameters of the supercritical adsorption process, the type of substance used, and the aerogel used, which is confirmed by studies of the impregnation of active substances into aerogels, which are presented in the literature [ 5 , 10 , 11 , 12 , 13 , 14 ]. Thus, it is clear that supercritical adsorption is a complex process that includes many phenomena and its study seems relevant.…”

Section: Introductionmentioning

confidence: 71%

See 1 more Smart Citation

Experimental Investigation and CFD Modeling of Supercritical Adsorption Process

2020

View full text Add to dashboard Cite

The kinetics of the supercritical adsorption process was experimentally studied by the example of ”ibuprofen-silica aerogel” composition obtainment at various parameters: Pressure 120–200 bar and temperature 40–60 °C. Computational Fluid Dynamics (CFD) model of the supercritical adsorption process in a high-pressure apparatus based on the provisions of continuum mechanics is proposed. Using supercritical adsorption process kinetics experimental data, the dependences of the effective diffusion coefficient of active substance in the aerogel, and the maximum amount of the adsorbed active substance into the aerogel on temperature and pressure are revealed. Adequacy of the proposed model is confirmed. The proposed mathematical model allows predicting the behavior of system (fields of velocity, temperature, pressure, composition, density, etc.) at each point of the studied medium. It makes possible to predict mass transport rate of the active substance inside the porous body depending on the geometry of the apparatus, structure of flow, temperature, and pressure.

show abstract

Section: Introductionmentioning

confidence: 71%

“…Such materials can be used as drug delivery systems (creation of new drug compositions). As shown in some works [ 5 ], active substances adsorbed on the inner surface of an aerogel are predominantly in an amorphous state. Due to this, their release rate is significantly higher compared to the active substances in crystalline form.…”

Section: Introductionmentioning

confidence: 99%

Experimental Investigation and CFD Modeling of Supercritical Adsorption Process

2020

View full text Add to dashboard Cite

show abstract

“…Supercritical drug impregnation has been successfully applied over the last years to different types of supports, mainly "non-swellable" materials like silicas or "swellable" matrices like polymers. This technic is suitable for a drug amorphization [10]. The current new trend for SC impregnation is to impregnate medical devices [11] since it is possible to perform a homogeneous drug impregnation without modifying the properties of the impregnated support [12].…”

Section: Choice Of Operating Conditionsmentioning

confidence: 99%

Current situation and perspectives in drug formulation by using supercritical fluid technology

Badens

Masmoudi

Mouahid

et al. 2018

The Journal of Supercritical Fluids

View full text Add to dashboard Cite

Supercritical fluid (SCF) technology has been applied to drug product development over the last thirty years and drug particle generation using SCFs appears to be an efficient way to carry out drug formulation which will form end-products meeting targeted specifications. This article presents an overview of drug particle design using SCFs from a rather different perspective than usual, more focused on chemical and process engineering aspects. The main types of existing processes are described in a concise way and a focus is put on how to choose the right operating conditions considering both thermodynamic and hydrodynamic aspects. It is shown that the operating conditions and parameters can be easily optimized so as to facilitate the further process scale-up. Furthermore, the new trends in particle generation using SCFs are introduced, related either to new types of drug medicines that are treated or new ways of process implementation methods.

show abstract

“…Due to their high loading capacity, polysaccharides based materials were suggested as a drug particle for many delivery applications [ 19 , 20 , 21 , 22 ]. Moreover, hybrid polymers find their way as drug particles [ 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Hybrid Alginate-Chitosan Aerogel as Potential Carriers for Pulmonary Drug Delivery

2020

View full text Add to dashboard Cite

This study aims to prepare hybrid chitosan-alginate aerogel microparticles without using additional ionic crosslinker as a possible pulmonary drug delivery system. The microparticles were prepared using the emulsion gelation method. The effect of the mixing order of the biopolymer within the emulsion and the surfactant used on final particle properties were investigated. Physicochemical characterizations were performed to evaluate particle size, density, morphology, surface area, surface charge, and the crystallinity of the preparation. The developed preparation was evaluated for its acute toxicity in adult male Sprague-Dawley rats. Measurements of zeta potential suggest that the surface charge depends mainly on the surfactant type while the order of biopolymer mixing has less impact on the surface charge. Chitosan amphiphilic properties changed the hydrophilic-lipophilic balance (HLB) of the emulsifying agents. The specific surface area of the prepared microparticles was in the range of (29.36–86.20) m2/g with a mesoporous pore size of (12.48–13.38) nm and pore volume of (0.09–0.29) cm3/g. The calculated aerodynamic diameter of the prepared particles was in the range of (0.17–2.29 µm). Toxicity studies showed that alginate-chitosan carrier developed herein caused mild lung inflammation with some renal and hepatic toxicities.

show abstract

Amorphization of drugs by adsorptive precipitation from supercritical solutions: A review

Cited by 85 publications

References 122 publications

Experimental Investigation and CFD Modeling of Supercritical Adsorption Process

Experimental Investigation and CFD Modeling of Supercritical Adsorption Process

Current situation and perspectives in drug formulation by using supercritical fluid technology

Preparation of Hybrid Alginate-Chitosan Aerogel as Potential Carriers for Pulmonary Drug Delivery

Contact Info

Product

Resources

About