Amorphization of thiamine chloride hydrochloride: A study of the crystallization inhibitor properties of different polymers in thiamine chloride hydrochloride amorphous solid dispersions

Arıoğlu-Tuncil, Seda; Bhardwaj, V.; Taylor, Lynne S.; Mauer, Lisa J.

doi:10.1016/j.foodres.2017.05.021

Cited by 11 publications

(27 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moisture‐induced crystallization in solid dispersions has been widely investigated (Arioglu‐Tuncil et al, ; Karel et al, ; Roos & Karel, ; Slade & Levine, ; Wegiel, Mauer, Edgar, & Taylor, ). The greater crystallization tendencies in higher moisture systems have been explained by the water plasticization and greater mobility facilitating the rotational diffusion needed for the vitamin to reorient into the more energetically favorable crystalline physical form, which has been shown to occur more rapidly in amorphous matrices plasticized above the T g (Roos & Karel, ; Rumondor & Taylor, ; Slade & Levine, ).…”

Section: Resultsmentioning

confidence: 99%

“…Previous studies have reported that samples stored in RH‐temperature environments that exceed the T g,mix facilitate molecular mobility and support crystallization (Roos & Karel, ; Slade & Levine, ). However, the dispersion of a small molecule in a compatible polymer matrix can inhibit the crystallization of the molecule by reducing mobility and limiting reorientation, even above the T g,mix (Arioglu‐Tuncil et al, ; Shamblin & Zografi, ). As shown in Figure , vitamins had crystallized in some VPSD formulations, those containing the highest vitamin proportions, during the moisture sorption profiling experiments.…”

Section: Resultsmentioning

confidence: 99%

“…Moisture sorption differences among VPSDs containing different vitamin weight proportions were examined using the ascribed parameter “phi” (Arioglu‐Tuncil, Bhardwaj, Taylor, & Mauer, ; Sanchez et al, ), which described the moisture sorption deviation of a VPSD from that of its respective pure polymer (PVP) as shown in Equation (2). The phi parameter was calculated from a linear model where the total moisture sorption of a VPSD equaled the weighted average moisture sorption of the pure PVP polymer plus phi:

m_{VPSD} = c m_{polymer} + φ

where m is the percent weight change attributable to moisture sorption, and c is the weight average of PVP in the VPSD formulation.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Phase transitions of ascorbic acid and sodium ascorbate in a polymer matrix and effects on vitamin degradation

Ismail

Mauer

2019

J Food Process Engineering

Self Cite

View full text Add to dashboard Cite

The phase transformations and stability of the two most common forms of vitamin C (ascorbic acid [AA] and sodium ascorbate) were explored in colyophilized polyvinylpyrrolidone polymer matrices. Solutions containing controlled vitamin:polymer ratios (0:100 to 100:0) were lyophilized and stored in controlled temperature (20-60 C) and relative humidity (0-85%RH) environments. Samples were analyzed over time using X-ray diffraction to document physical state and high performance liquid chromatography to document vitamin degradation. Moisture sorption profiling, microscopy, infrared spectroscopy, and differential scanning calorimetry were also used to characterize the samples.Vitamins were more labile when amorphous than when crystalline, and sodium ascorbate was more labile than AA. Significant vitamin degradation occurred in the glassy state. All vitamins degraded significantly more when present at lower proportions in the amorphous solid dispersions, thus most degradation was found in the dispersions with the highest glass transition temperatures.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

m_{VPSD} = c m_{polymer} + φ

where m is the percent weight change attributable to moisture sorption, and c is the weight average of PVP in the VPSD formulation.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Phase transitions of ascorbic acid and sodium ascorbate in a polymer matrix and effects on vitamin degradation

Ismail

Mauer

2019

J Food Process Engineering

Self Cite

View full text Add to dashboard Cite

show abstract

“…At 5-and 9-prints, an endothermic peak around 260 • C was present as a sequence of an exothermic peak. These peaks indicate the recrystallization of THCl upon heating, followed by the melting of the substance [52]. Two broad endotherm peaks were detected in the temperature range of 70-150 • C and 190-250 • C for the plain sugar sheet and the formulations.…”

Section: Discussionmentioning

confidence: 96%

Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

et al. 2020

View full text Add to dashboard Cite

Buccal films containing two vitamins, i.e., thiamine hydrochloride (THCl) and nicotinic acid (NA), were fabricated via two-dimensional (2D) inkjet printing. For the preparation of buccal films, solubility studies and rheological evaluations were conducted in distilled water and propylene-glycol (PG) as main solvent and viscosity/surface tension modifier, respectively. The increased solubility in the solvents’ mixture indicated that manufacturing of several doses of the THCl and NA is achievable. Various doses were deposited onto sugar-sheet substrates, by increasing the number of printing passes. The physiochemical characterization (SEM, DSC, FTIR) revealed that inkjet printing does not affect the solid state of the matrix. Water uptake studies were conducted, to compare the different vitamin-loaded formulations. The in vitro release studies indicated the burst release of both vitamins within 10 min, a preferable feature for buccal administration. The in vitro permeation studies indicated that higher concentrations of the vitamins onto the sugar sheet improved the in vitro permeation performance of printed formulations.

show abstract

“…Although the salt forms of thiamine are distributed in the crystalline form, the amorphous form of small molecules can be produced following interactions with polymers in solid dispersions and/or following some processing methods (e.g., freeze drying, spray drying, milling, grinding) [ 13 , 14 ]. A recent study documented that TClHCl interacts with a variety of polymers, enabling its solidification in the amorphous state when select ratios of thiamine and a polymer are co-lyophilized [ 15 ]. Freeze drying is commonly used as an amorphization technique to generate small sample amounts for experimental exploration; it is also used when heat may be harmful to the system, which could lead to degradation in the case of thiamine.…”

Section: Introductionmentioning

confidence: 99%

Amorphization of Thiamine Chloride Hydrochloride: Effects of Physical State and Polymer Type on the Chemical Stability of Thiamine in Solid Dispersions

Arıoğlu-Tuncil

Voelker

Taylor

et al. 2020

IJMS

Self Cite

View full text Add to dashboard Cite

Thiamine is an essential micronutrient, but delivery of the vitamin in supplements or foods is challenging because it is unstable under heat, alkaline pH, and processing/storage conditions. Although distributed as a crystalline ingredient, thiamine chloride hydrochloride (TClHCl) likely exists in the amorphous state, specifically in supplements. Amorphous solids are generally less chemically stable than their crystalline counterparts, which is an unexplored area related to thiamine delivery. The objective of this study was to document thiamine degradation in the amorphous state. TClHCl:polymer dispersions were prepared by lyophilizing solutions containing TClHCl and amorphous polymers (pectin and PVP (poly[vinylpyrrolidone])). Samples were stored in controlled temperature (30–60 °C) and relative humidity (11%) environments for 8 weeks and monitored periodically by X-ray diffraction (to document physical state) and HPLC (to quantify degradation). Moisture sorption, glass transition temperature (Tg), intermolecular interactions, and pH were also determined. Thiamine was more labile in the amorphous state than the crystalline state and when present in lower proportions in amorphous polymer dispersions, despite increasing Tg values. Thiamine was more stable in pectin dispersions than PVP dispersions, attributed to differences in presence and extent of intermolecular interactions between TClHCl and pectin. The results of this study can be used to control thiamine degradation in food products and supplements to improve thiamine delivery and decrease rate of deficiency.

show abstract

Amorphization of thiamine chloride hydrochloride: A study of the crystallization inhibitor properties of different polymers in thiamine chloride hydrochloride amorphous solid dispersions

Cited by 11 publications

References 46 publications

Phase transitions of ascorbic acid and sodium ascorbate in a polymer matrix and effects on vitamin degradation

Phase transitions of ascorbic acid and sodium ascorbate in a polymer matrix and effects on vitamin degradation

Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

Amorphization of Thiamine Chloride Hydrochloride: Effects of Physical State and Polymer Type on the Chemical Stability of Thiamine in Solid Dispersions

Contact Info

Product

Resources

About