Amorphous and Crystalline Magnesium Alloys for Biomedical Applications

Cesarz-Andraczke, Katarzyna; Kania, A.; Młynarek, Katarzyna; Babilas, R.

doi:10.5772/intechopen.94914

Cited by 3 publications

(2 citation statements)

References 57 publications

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“…This would mean a shortening of patients’ recovery time as well as a reduction in treatment costs. However, the excessive rate of degradation and the resulting evolution of hydrogen [ 11 , 12 ] has led to the abandonment of further work on the biomedical use of crystalline magnesium alloys. The literature can also be found with studies on improving the energy condition of metallic glasses leading to the formation of nanostructural metallic glasses, expanding their use, such as highly efficient catalysts for energy conversion [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Crystallization Kinetics Analysis of the Binary Amorphous Mg72Zn28 Alloy

et al. 2023

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The aim of the study was to analyze the crystallization kinetics of the Mg72Zn28 metallic glass alloy. The crystallization kinetics of Mg72Zn28 metallic glass were investigated by differential scanning calorimetry and X-ray diffraction. The phases formed during the crystallization process were identified as α-Mg and complex Mg12Zn13 phases. Activation energies for the glass transition temperature, crystallization onset, and peak were calculated based on the Kissinger model. The activation energy calculated from the Kissinger model was Eg = 176.91, Ex = 124.26, Ep1 = 117.49, and Ep2 = 114.48 kJ mol−1, respectively.

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Section: Introductionmentioning

confidence: 99%

Crystallization Kinetics Analysis of the Binary Amorphous Mg72Zn28 Alloy

et al. 2023

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“…This element plays an essential role in the formation of antibodies and in the blood clotting process. In the skeletal system, Mg is responsible for the proper absorption of calcium, activates the osteosis process, improves bone tissue density, and stimulates the hormone that triggers the release of calcium from the blood and deposition in the bones [ 1 ]. Pure magnesium possesses mechanical properties close to human bone, compared to clinically used materials [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Rapid Solidification on Corrosion Behavior of Mg60Zn20Yb15.7Ca2.6Sr1.7 Alloy for Medical Applications

et al. 2021

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Biodegradable magnesium alloys with Zn, Yb, Ca and Sr additions are potential materials with increased corrosion resistance in physiological fluids that ensure a controlled resorption process in the human body. This article presents the influence of the use of a high cooling rate on the corrosion behavior of Mg60Zn20Yb15.7Ca2.6Sr1.7 alloy proposed for medical applications. The microstructure of the alloy in a form of high-pressure die-casted plates was presented using scanning electron microscopy in the backscattered electrons (BSEs) mode with energy-dispersive X-ray spectrometer (EDX) qualitative analysis of chemical composition. The crystallization mechanism and thermal properties were described on the basis of differential scanning calorimetry (DSC) results. The corrosion behavior of Mg60Zn20Yb15.7Ca2.6Sr1.7 alloy was analyzed by electrochemical studies with open circuit potential (EOCP) measurements and polarization tests. Moreover, light microscopy and X-ray photoelectron spectroscopy were used to characterize the corrosion products formed on the surface of studied samples. On the basis of the results, the influence of the cooling rate on the improvement in the corrosion resistance was proved. The presented studies are novel and important from the point of view of the impact of the technology of biodegradable materials on corrosion products that come into direct contact with the tissue environment.

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Haematological and Biochemical Parameters of Blood in Patients after BIOS of the Tibia using Bioinert and Biodegradable Implants based on Magnesium Alloy MA-10

Yatsun

Holovakha

Maslennikov³

et al. 2022

Biomed. Pharmacol. J.

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Nowadays, the search for new artificial materials to replace damaged tissues and organs is becoming increasingly important. Biodegradable materials occupy an honorable place among medical materials. Depending on the purpose, biodegradable implants should be gradually replaced by living tissue and function over a given period of time, as well as not have a negative impact on surrounding tissues and the body as a whole. Magnesium-based alloys are considered promising. Clinical studies of the dynamics of a number of key biochemical parameters that characterize the reactive response and regenerative processes in the body are of scientific and practical importance. The aim of the research was to study the laboratory - biochemical parameters of blood in patients after BIOS of the tibia using bioinert and biodegradable implants based on magnesium alloy MA-10 Materials and methods. 36 patients with tibial fractures were operated in the traumatology department of MNCE “CH of Emergency and Urgent Medical Aid” in Zaporizhzhia. After closed repositioning, the tibial BIOS was performed using biodegradable alloy screws. Blood sampling for biochemical and cytological studies was performed before and in 2, 4 weeks, 2 and 4 months after surgery. Biodegradable magnesium alloy MA-10 (TU U 24.4-14307794-270: 2018) certified for use in medicine. Results. The study of the total bilirubin dynamics in blood plasma showed that the maximum values of the indicator accompany the acute period of the pathological process. From the second week, slight fluctuations in α-amylase activity were detected, which is most likely due to the energetic support of the inflammatory process and the regeneration of damaged tissues. The use of magnesium alloy for the manufacture of screws showed stable enzyme activity for 4 weeks. In the group of patients who used magnesium alloy implants immediately after surgery, there was a significant (p≤0.05) increase in AST / ALT by 44%, compared with the initial value of the de Ritis coefficient, not by increasing the activity of AST, but by reducing activity ALT. The undulating dynamics of ESR, fibrinogen B and total bilirubin in the blood of patients of both groups reflects the stages of the reparative process. Conclusions. The bioinertness and expediency of using implants made of biodegradable magnesium alloy MA-10 in the dynamic BIOS for diaphyseal fractures of the tibia are substantiated.

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Amorphous and Crystalline Magnesium Alloys for Biomedical Applications

Cited by 3 publications

References 57 publications

Crystallization Kinetics Analysis of the Binary Amorphous Mg72Zn28 Alloy

Crystallization Kinetics Analysis of the Binary Amorphous Mg72Zn28 Alloy

The Influence of Rapid Solidification on Corrosion Behavior of Mg60Zn20Yb15.7Ca2.6Sr1.7 Alloy for Medical Applications

Haematological and Biochemical Parameters of Blood in Patients after BIOS of the Tibia using Bioinert and Biodegradable Implants based on Magnesium Alloy MA-10

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