Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca<sup>2+</sup>-enriched surfaces

Enriquez, Darlin Johana Perez; Arciprete, María L. Dell’; Dittler, María Laura; Miñán, Alejandro; Prieto, Eduardo; González, Mónica C.

doi:10.1039/c9nj06414a

Cited by 2 publications

(3 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The heterogeneous nucleation of CaP on surfaces rich in phosphate ester groups is common and can be used to create specific shapes of the mineral phase, oriented growth of crystals [99] and more complex hierarchical structures. Examples include hollow shells grown on phospholipid vesicles [100] and templated growth on DNA molecules [101]. Examples of nucleation of CaP by phosphoproteins are given in Section 2.3.…”

Section: Nucleation Versus Inhibitionmentioning

confidence: 99%

Structural Biology of Calcium Phosphate Nanoclusters Sequestered by Phosphoproteins

et al. 2020

View full text Add to dashboard Cite

Biofluids that contain stable calcium phosphate nanoclusters sequestered by phosphopeptides make it possible for soft and hard tissues to co-exist in the same organism with relative ease. The stability diagram of a solution of nanocluster complexes shows how the minimum concentration of phosphopeptide needed for stability increases with pH. In the stable region, amorphous calcium phosphate cannot precipitate. Nevertheless, if the solution is brought into contact with hydroxyapatite, the crystalline phase will grow at the expense of the nanocluster complexes. The physico-chemical principles governing the formation, composition, size, structure, and stability of the complexes are described. Examples are given of complexes formed by casein, osteopontin, and recombinant phosphopeptides. Application of these principles and properties to blood serum, milk, urine, and resting saliva is described to show that under physiological conditions they are in the stable region of their stability diagram and so cannot cause soft tissue calcification. Stimulated saliva, however, is in the metastable region, consistent with its role in tooth remineralization. Destabilization of biofluids, with consequential ill-effects, can occur when there is a failure of homeostasis, such as an increase in pH without a balancing increase in the concentration of sequestering phosphopeptides.

show abstract

Section: Nucleation Versus Inhibitionmentioning

confidence: 99%

Structural Biology of Calcium Phosphate Nanoclusters Sequestered by Phosphoproteins

et al. 2020

View full text Add to dashboard Cite

show abstract

“…[3] In addition, these inherently biocompatible compounds stand among the preferred building blocks for the development of advanced biomedical materials, finding applications beyond bone repairment, [4] as drug or gene delivery. [5][6][7] Moreover, due to their countless industrial uses, these nanophases belong to the most massively produced nanoparticles. [8] Depending on the desired application, these building blocks must fulfil several requirements including controlled shape, size, composition and crystalline structure.…”

Section: Introductionmentioning

confidence: 99%

“…Nanotextured calcium phosphates and their complex transformations are permanently studied from a fundamental point of view [1] since they play a key biological role in osteogenesis [2] and the constitution of hard tissues in vertebrates [3] . In addition, these inherently biocompatible compounds stand among the preferred building blocks for the development of advanced biomedical materials, finding applications beyond bone repairment, [4] as drug or gene delivery [5–7] . Moreover, due to their countless industrial uses, these nanophases belong to the most massively produced nanoparticles [8]…”

Section: Introductionmentioning

confidence: 99%

Amorphous Calcium Phosphates: Solvent‐Controlled Growth and Stabilization through the Epoxide Route

Borovik

Oestreicher

Huck‐Iriart

et al. 2021

Chemistry A European J

View full text Add to dashboard Cite

Calcium phosphates stand among the most promising nanobiomaterials in key biomedical applications, such as bone repairment, signalling or drug/gene delivery. Their intrinsic properties as crystalline structure, composition, particle shape and size define their successful use. Among these compounds, metastable amorphous calcium phosphate (ACP) is currently gaining particular attention due to its inherently high reactivity in solution, which is crucial in bone development mechanisms. However, the preparation of this highly desired (bio)material with control over its shape, size and phase purity remains as a synthetic challenge. In this work, the epoxide route was adapted for the synthesis of pure and stable ACP colloids. By using biocompatible solvents, such as ethylene glycol and/or glycerine, it was possible to avoid the natural tendency of ACP to maturate into more stable and crystalline apatites. Moreover, this procedure offers size control, ranging from small nanoparticles (60 nm) to micrometric spheroids (>500 nm). The eventual fractalization of the internal mesostructured can be tuned, by simply adjusting the composition of the ethylene glycol:glycerine solvent mixture. These findings introduce the use of green solvents as a new tool to control crystallinity and/or particle size in the synthesis of nanomaterials, avoiding the use of capping agents and preserving the natural chemical reactivity of the pristine surface.

show abstract

Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca²⁺-enriched surfaces

Abstract: Our amorphous calcium organophosphate nanoshells are prone to agglomerate and disassemble when Ca2+ ions are present in the solution and on surfaces. This have great implications for targeting and drug release in Ca-rich environments, such as bone.

Cited by 2 publications

References 47 publications

Structural Biology of Calcium Phosphate Nanoclusters Sequestered by Phosphoproteins

Structural Biology of Calcium Phosphate Nanoclusters Sequestered by Phosphoproteins

Amorphous Calcium Phosphates: Solvent‐Controlled Growth and Stabilization through the Epoxide Route

Contact Info

Product

Resources

About

Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca2+-enriched surfaces

Abstract: Our amorphous calcium organophosphate nanoshells are prone to agglomerate and disassemble when Ca2+ ions are present in the solution and on surfaces. This have great implications for targeting and drug release in Ca-rich environments, such as bone.

Cited by 2 publications

References 47 publications

Structural Biology of Calcium Phosphate Nanoclusters Sequestered by Phosphoproteins

Structural Biology of Calcium Phosphate Nanoclusters Sequestered by Phosphoproteins

Amorphous Calcium Phosphates: Solvent‐Controlled Growth and Stabilization through the Epoxide Route

Contact Info

Product

Resources

About

Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca²⁺-enriched surfaces