2018
DOI: 10.3390/cryst8060254
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Amorphous Calcium Phosphate Formation and Aggregation Process Revealed by Light Scattering Techniques

Abstract: Amorphous calcium phosphate (ACP) attracts attention as a precursor of crystalline calcium phosphates (CaPs) formation in vitro and in vivo as well as due to its excellent biological properties. Its formation can be considered to be an aggregation process. Although aggregation of ACP is of interest for both gaining a fundamental understanding of biominerals formation and in the synthesis of novel materials, it has still not been investigated in detail. In this work, the ACP aggregation was followed by two wide… Show more

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Cited by 29 publications
(20 citation statements)
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(100 reference statements)
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“…Therefore the reaction progress can be followed by monitoring the pH changes in the system of interest [33,[43][44][45][46]. Typically, sigmoidal pH vs. time curves are obtained, in which [33,[43][44][45][46][47]: − In the initial precipitation stage (stage I), slight or negligible pH changes are observed, which correspond to the formation of ACP; − A subsequent rapid decrease in pH (stage II) is associated with secondary precipitation of crystalline phase upon the formation of ACP; − A final slight pH change (stage III) corresponds to the solution-mediated crystal growth and phase transformation of the crystalline phase formed in stage II.…”
Section: Influence Of Amino Acids On the Rate Of Cap Transformationmentioning
confidence: 99%
“…Therefore the reaction progress can be followed by monitoring the pH changes in the system of interest [33,[43][44][45][46]. Typically, sigmoidal pH vs. time curves are obtained, in which [33,[43][44][45][46][47]: − In the initial precipitation stage (stage I), slight or negligible pH changes are observed, which correspond to the formation of ACP; − A subsequent rapid decrease in pH (stage II) is associated with secondary precipitation of crystalline phase upon the formation of ACP; − A final slight pH change (stage III) corresponds to the solution-mediated crystal growth and phase transformation of the crystalline phase formed in stage II.…”
Section: Influence Of Amino Acids On the Rate Of Cap Transformationmentioning
confidence: 99%
“…Carrageenans, locust bean gum, guar gum, gellan gum, gum arabic, xanthan or pectin fibrous structures were also investigated (Funami, 2010;Gunning & Morris, 2018;Ikeda, Funami, & Zhang, 2005;Liu & Wang, 2011;Wang & Somasundaran, 2007). Crystalline structures of lactose (Dincer, Ogden, & Parkinson, 2014;Gao et al, 2017;Perkins et al, 2007), of saccharose (Masterson & Cao, 2008;Middendorf et al, 2016Middendorf et al, , 2018 or of calcium phosphate assemblies (Li, Wang, & Putnis, 2018;Wang, Lu, Xu, & Zhang, 2011;Čadež et al, 2018) are also accessible using AFM imaging.…”
Section: Imaging Structures and Dynamics At Surfacesmentioning
confidence: 99%
“…4C), which further aggregate into chains prior to transforming toward a more stable phase. [36][37][38][39] In the late 1990s, it was proposed that crystalline HA forms via the step-wise assembly of Posner's clusters. 34 However, speculation over the exact chemical composition of physiologically derived clusters and the applicability of this model for in vivo biomineral formation has only driven further efforts to understand the chemical structure of these early orthophosphate building blocks.…”
Section: Nucleation Of An Amorphous Mineral Precursormentioning
confidence: 99%