Amorphous magnetic microspheres for biomedical applications

Chiriac, H.; Moga, A.; Iacob, Gheorghe; Mungiu, O C

doi:10.1016/j.jmmm.2005.01.039

Cited by 9 publications

(6 citation statements)

References 3 publications

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“…These magnetic characters for the microspheres are due to the relative big size of the formed microspheres [24], and that led to decrease in the magnetic interactions between the microspheres with the blood hemoglobin.…”

Section: Discussionmentioning

confidence: 99%

Study of the Effect of Magnetic Microspheres on Some Biophysical Parameters of Human Blood (In vitro Study)

Hereba¹

2012

J Biotechnol Biomaterial

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Magnetic microspheres have many bio-medical applications, but they have contact with the blood before reaching to their target place in many cases, so the study of the effect of these microspheres on the blood can lead to optimization of the use of these microspheres. Five groups of normal blood samples were incubated with 10 mg magnetic chitosan microspheres for 1, 3, 6, 12, and 24 hours (h) respectively, then each group was compared to control group samples. The results showed that increase in hemoglobin conductivity with the time of incubation, no change in red blood cells osmotic fragility, no change in hemoglobin absorbance spectrum. Decrease in blood pH at 24 h, no change in neither hemoglobin electrophoretic patterns or in the blood components ultra structures. These results indicated no obvious toxicity of the magnetic microspheres on blood for incubation time up to 24 h, but on the other hand there are some changes especially at 24 h of incubation, so it is safer to avoid the remaining of the microspheres inside the body for more than 24 h.

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Section: Discussionmentioning

confidence: 99%

Study of the Effect of Magnetic Microspheres on Some Biophysical Parameters of Human Blood (In vitro Study)

Hereba¹

2012

J Biotechnol Biomaterial

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“…Застосування аморфних металевих сплавів (АМС) на основі феруму з високою магнітною сприйнятливістю розширюється в нових напрямках [4][5][6], таких як медицина, біологія і, разом з тим, виникає проблема їх захисту від специфічних агресивних середовищ полімерними покриттями. При цьому відкривається також можливість застосування полімерних пероксидних покривів як антисептичних засобів, а також іммобілізаторів лікарських препаратів.…”

Section: системуunclassified

Optimization of the preparation of oligoperoxide films on an amorphous metallic surface Fe-(Ме)-Si-B

Hertsyk¹,

Kovbuz²,

Yezerska³

et al. 2009

Chem. Met. Alloys

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Investigations of the corrosion resistance of protecting oligoperoxide coatings on magnetic soft amorphous metallic alloys constitute an important task for technical applications these materials. The influence of the oligoperoxide concentration, chemical composition of the amorphous alloy (Fe 78.5 Ni 1.0 Mo 0.5 Si 6.0 B 14.0 or Fe 73.1 Cu 1.0 Nb 3.0 Si 15.5 B 7.4) and the time of film creation on the stability of the coating was investigated by electrochemical impedance spectroscopy (EIS), potentiometry, electron microscopy, and measurements of the wetting angle. Oligoperoxides based on vinyl acetate, 2-tert-butylperoxy-2-methyl-5-hexene-3-yne and maleic anhydride were used in the experiments. The effect of the factors mentioned above on the film formation process on the surface of amorphous alloys is discussed.

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“…these systems so far developed give release rates that are either constant or decrease with time, but not augmented delivery on demand [3] . It can be achieved with the systems, which are associated with external or feed back control such as magnetic control [4] . Magnetically targeted drug delivery system (MT-DDS) will be a promising way, which involves binding a drug to a small biocompatible magnetically active component, entrapped in the biodegradable polymeric matrix and formulating in to a pharmacologically active stable formulation, which is injected into the blood stream and using a high-gradient magnetic field to pull them out of suspension in the target region [5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Magnetic Methyl Methacrylate Microspheres Loaded with Indomethacin by Emulsion Solvent Evaporation Technique.

Varma¹,

Amareshwar²,

Devara³

2011

Int J Drug Del

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Magnetic nanoparticles encapsulated in Methyl methacrylate (Eudragit L-100) microspheres containing Indomethacin drug were prepared and their detailed structural and magnetic characteristics were studied. Iron oxide nanoparticles were obtained by chemical coprecipitation of Fe(II) and Fe(III) salts and stabilized with tetra-methyl ammonium hydroxide. Microspheres were prepared by solvent evaporation technique. We characterized the magnetic microspheres in terms of morphology, composite microstructure, size and size distribution, magnetic properties and in-vitro release patterns. The microspheres were uniform both in shape and usually also in size; their size distribution was narrow. All the magnetic parameters confirm superparamagnetic nature of the microspheres with magnetizations up to 20-30 emu/g of microspheres. The in-vitro release profile was studied in pH 7.4 phosphate buffer medium up to 8 hours using USP XXII dissolution apparatus. Drug release in the first hour was found to increase and reached a maximum, releasing approximately 60-85% of the total drug content from the microspheres within 8 hours. From this study, it could be suggested that magnetic Methyl methacrylate microspheres could be retained at their target site invivo and such microspheres can be used in biomedical applications and research areas such as target drug delivery, selective blood detoxification, tissue engineering and replacement, and magnetic resonance imaging (MRI) contrast agents.

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Amorphous magnetic microspheres for biomedical applications

Cited by 9 publications

References 3 publications

Study of the Effect of Magnetic Microspheres on Some Biophysical Parameters of Human Blood (In vitro Study)

Study of the Effect of Magnetic Microspheres on Some Biophysical Parameters of Human Blood (In vitro Study)

Optimization of the preparation of oligoperoxide films on an amorphous metallic surface Fe-(Ме)-Si-B

Synthesis and Characterization of Magnetic Methyl Methacrylate Microspheres Loaded with Indomethacin by Emulsion Solvent Evaporation Technique.

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