Amount of airflow required for olfactory perception in laryngectomees: a prospective interventional study

Manestar, Darko; Tićac, Robert; Maričić, Sven; Malvić, Goran; Čorak, Davor; Kavanagh, Marcel Marjanović; Prgomet, Drago; Starčević, Radan

doi:10.1111/j.1749-4486.2012.02442.x

Cited by 15 publications

(14 citation statements)

References 21 publications

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“…One branch of clinical research that has confirmed the association between olfactory function and nasal airflow has been in the area of restoration of olfactory function in laryngectomy patients using the polite yawning technique . Manestar et al demonstrated that the minimum total nasal airflow required for olfactory stimulation in successfully rehabilitated patients was approximately 60 cm/second. However, determining how much of that total nasal airflow is directed to the olfactory region is complicated by several factors.…”

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confidence: 99%

Conductive olfactory losses in chronic rhinosinusitis? A computational fluid dynamics study of 29 patients

Zhao

Jiang

Pribitkin

et al. 2014

Int Forum Allergy Rhinol

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Objective Besides sensorineural factors, conductive impediments likely contribute to olfactory losses in chronic rhinosinusitis (CRS) patients, yet no conclusive evidence exists. We aimed to examine possible conductive factors using computational fluid dynamics (CFD) models. Methods 29 CRS patients were assessed via odorant detection thresholds (ODTs), rhinomanometry (nasal resistance: NR), acoustic rhinometry (minimum-cross-sectional area: MCA) and CT staging. CFD simulations of nasal airflow and odorant absorption to olfactory region were carried out based on individual CTs. Biopsies of olfactory epithelium (OE) were collected, cryo-sectioned, stained and scored for erosion. Results Significant correlations to ODTs were found for three variables: odor absorption in the olfactory region (r=−0.60, p<0.01), MCA (r=−0.40, p<0.05) and CT staging (r=0.42, p<0.05). However, significant findings were limited to ODTs of the highly soluble l-carvone. Multiple regression analysis revealed that these variables combined, with the addition of NR, can account for 65% of the total variance in ODTs. CT staging correlated significantly with OE erosion (r=0.77, p<0.01) and can replace the latter in the regression with comparable outcomes. Partial correlations suggest the contributions of both conductive and sensorineural variables are more prominent if adjusted for the effects of the other. Olfactory loss and inflammatory factors have strong bilateral involvement, while conductive factors are independent between sides. As validation, CFD-simulated NRs significantly correlated with rhinomanometrically assessed ones (r=0.60, p<0.01). Conclusion Both conductive and sensorineural mechanisms can contribute to olfactory losses in CRS. CFD modeling provides critical guidance in understanding the role of conductive impediments in olfactory dysfunction in CRS.

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mentioning

confidence: 99%

Conductive olfactory losses in chronic rhinosinusitis? A computational fluid dynamics study of 29 patients

Zhao

Jiang

Pribitkin

et al. 2014

Int Forum Allergy Rhinol

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“…The majority of studies referrers as the main cause for olfaction disorder in this population the total separation of the upper and lower airways causing the transference of the nasal air flow to a permanent tracheostomy tube, which makes it difficult for the air to get to the nasal cavity, where the olfactory epitheliumis [5][6][7] .…”

Section: Discussionmentioning

confidence: 99%

“…The interruption of the nasal airflow due to total laryngectomy hinders the odor molecules of reaching the olfactory epithelium and stops its stimulation, resulting in olfaction disorders [5][6][7] . Therefore, the total laryngectomized patient has a decrease in the olfactory perception (hiposmia) or even a total absence of olfaction (anosmia) 8,9 .…”

Section: Conflict Of Interest: Non-existentmentioning

confidence: 99%

Acuidade olfatória e qualidade de vida após a laringectomia total

et al. 2015

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RESUMO: Objetivo: identificar a prevalência e os fatores associados às alterações do olfato e descrever a qualidade de vida após a laringectomia total. Métodos: estudo transversal para avaliar a acuidade olfatória e a qualidade de vida de laringectomizados totais no Instituto Nacional de Câncer por meio da aplicação do Teste de Identificação do Olfato da Universidade da Pensilvânia, do Questionário de Qualidade de Vida da Universidade de Washington e do Questionário sobre a Acuidade Olfatória Pré-Reabilitação do Olfato. Resultados: foram avaliados 48 laringectomizados totais, sendo 39 do sexo masculino e 9 do sexo feminino, com idade média de 62 anos e tempo médio de 5,6 anos desde a laringectomia total. No Teste de Identificação do Olfato a pontuação média foi de 17,9. De acordo com a classificação do olfato no teste, a maioria dos participantes apresentou algum grau de alteração, sendo que apenas 2 indivíduos tiveram o olfato considerado dentro da normalidade. No Questionário de Qualidade de vida da Universidade de Washington, o escore composto foi 80,47. Os domínios que apresentaram as médias de pontos mais baixas foram paladar, saliva e fala. No questionário sobre a acuidade olfatória pré-reabilitação do olfato, a maioria dos participantes consideraram seu olfato de ruim a razoável. 21 indivíduos relataram apresentar algum grau de dificuldade em suas atividades de vida diária em decorrência de alterações do olfato. Conclusão: os laringectomizados totais apresentaram alta prevalência de alterações do olfato, com comprometimentos relacionados às suas atividades de vida diária.

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“…Der Test ist sechs Monate haltbar und kann in dieser Zeit beliebig oft eingesetzt werden. Angewandt wurde er bisher zur Objektivierung von Geruchsstörungen vor und nach Laryngektomien sowie operativen Eingriffen im nasalen Bereich [75,76]. Erhältlich ist er bei der Firma Novimed Medizintechnik (Dietikon, Schweiz; www.smelldiskettes.com).…”

Section: Smell Diskettes Olfaction Testunclassified

Störungen des Geruchssinns: Psychiatrisch-neurologische Bezüge und Diagnostik

Waldmann

Lübke

Pentzek

et al. 2020

Fortschr Neurol Psychiatr

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ZusammenfassungUntersuchungen zur olfaktorischen Wahrnehmung bei psychiatrischen und neurodegenerativen Erkrankungen zeigen vielfältige Veränderungen auf psychophysikalischer, neurophysiologischer und anatomischer Ebene. Diese Veränderungen stellen sich zum Teil erkrankungsspezifisch dar. So wird z. B. die dysfunktionale Geruchswahrnehmung bei affektiven Erkrankungen mit anatomisch-funktionellen Überlappungen von geruchs- und emotionsverarbeitenden Arealen in Verbindung gebracht. Auf Basis der aktuellen Datenlange zur veränderten Riechfähigkeit bei Major Depression, Schizophrenie, Alzheimer-Demenz und der Parkinson-Erkrankung wird hier die Erfassung der olfaktorischen Wahrnehmung als zusätzlicher diagnostischer Marker bei neuropsychiatrischen Erkrankungen diskutiert. Dabei besteht die Notwendigkeit einer objektiven Erfassung der Riechfunktion über validierte Testverfahren, verknüpft mit Kenntnissen in der Interpretation der erhaltenen Befunde. Ziel dieser Übersichtsarbeit ist es, die Veränderungen der olfaktorischen Wahrnehmung bei den genannten Erkrankungen darzustellen und ausgewählte, im deutschen Sprachraum verfügbare Verfahren vorzustellen und anwendungsbezogen einzuordnen. Eigene aktuelle Daten zur Validierung eines Geruchsdiskriminationstests (Düsseldorf Odour Discrimination Test) an einer klinischen Stichprobe werden vorgestellt.

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Amount of airflow required for olfactory perception in laryngectomees: a prospective interventional study

Cited by 15 publications

References 21 publications

Conductive olfactory losses in chronic rhinosinusitis? A computational fluid dynamics study of 29 patients

Conductive olfactory losses in chronic rhinosinusitis? A computational fluid dynamics study of 29 patients

Acuidade olfatória e qualidade de vida após a laringectomia total

Störungen des Geruchssinns: Psychiatrisch-neurologische Bezüge und Diagnostik

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